Abstract: A three-dimensional (3D)) object production process comprising providing a thermoset printing apparatus comprising a mixing chamber to receive and mix at least a first reactive component and a second reactive component to provide a thermosetting material, an extrusion nozzle to deliver the thermosetting material to form a 3D object, at least one actuator coupled to the extrusion nozzle to move the extrusion nozzle when delivering the thermosetting material to form the 3D object, and a controller comprising one or more processors and coupled to the extruded thermoset printing apparatus, and depositing the thermosetting material to form the 3D object, wherein the depositing comprises depositing a first layer of thermosetting material and depositing an at least second layer of thermosetting material, wherein the beads of thermosetting material in the at least second layer are offset from the beads of thermosetting material in the first layer.

Abstract: New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.

Abstract: Disclosed are dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the pharmaceutical compositions, isomers, intermediates thereof and processes for preparing these dihydropteridinones. The compounds are useful the treatment and/or prevention of cancer, infections, inflammatory and autoimmune diseases.

Abstract: A laser for generating pulsed laser radiation is provided, having a resonator, a laser-active medium, which is situated in the resonator, a Q-switch, which is situated in the resonator, and which can be put into a first state and a second state to set the resonator quality. The resonator quality is lower in the first state than in the second state. The laser also may have a detection unit, which, when the Q-switch is in the second state, measures the intensity of the building laser pulse and outputs it as an intensity signal. The laser may further have a control unit for controlling the Q-switch, which, as a function of a predetermined pulse duration and the applied intensity signal, switches the Q-switch from the second state into the first state, before the pulse buildup of the laser pulse is completed.

Abstract: Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract: The invention relates to a device and a method for transmitting simulation models (11, 18) between simulators (10, 17), the device having a first input/output element (22), to which the simulation model (11) is transmitted from the first simulator (11), having a processing unit (24), which, after the simulation model (11) has been transmitted, separates the model into individual operators (12) and stores the operator association (16), wherein the operators (12) that can be integrated, as external operators (19) and with semantic equivalence, by the second simulator (17) with the aid of the operator association (16) can be compiled into an operator library (12 [sic]), the device further having a second input/output element (23), which outputs the operator library and additionally provides the operator association (16).