Patents by Inventor Matthias Hoffmann

Matthias Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10947243
    Abstract: The invention relates to new substituted heteroaryls of formula 1 wherein A is selected from the group consisting of N and CH D is selected from the group consisting of CH, N, NH, S and O, E is selected from the group consisting of C and N, T is selected from the group consisting of C and N, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: March 16, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Georg Dahmann, Matthias Hoffmann, Jasna Klicic Badoux, David James Lamb, Clive McCarthy, Spencer Charles R. Napier, Karen Parrish, John Scott, Jennifer L. Swantek Fitzgerald, Edward Walker
  • Publication number: 20210070878
    Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: August 17, 2020
    Publication date: March 11, 2021
    Inventors: Tobias Raum, Markus Münz, Johannes Brozy, Peter Kufer, Patrick Hoffmann, Matthias Friedrich, Benno Rattel, Pamela Bogner, Andreas Wolf, Cornelius Pompe
  • Publication number: 20210049301
    Abstract: A method for combining different partial data includes providing a secure connection between a connection unit in a first network and an analysis unit a second network, separating original data into at least two items of partial data comprised of analysis data and personal data as first and second partial data that can be assigned to each other by way of assigning information, pseudonymizing the second partial data, transmitting the first partial data and pseudonymized second partial data and the assigning information to the analysis unit, storing the second partial data on the connection unit, providing third partial data on the analysis unit in the form of analyzed first partial data, transmitting the third partial data and the pseudonymized second partial data with the assigning information to the connection unit via the secure connection, and combining the third partial data and the second partial data using the assigning information.
    Type: Application
    Filed: April 26, 2019
    Publication date: February 18, 2021
    Inventors: Johannes Gregori, Sigurd Randoll, Stefan Hoffmann, Matthias Günther
  • Publication number: 20200362039
    Abstract: The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an antigen selected from the group consisting of Prostate Stem Cell Antigen (PSCA), B-Lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), Endosialin, the EGF-like domain 1 of EpCAM, encoded by exon 2, Fibroblast activation protein alpha (FAP alpha) and Insulin-like growth factor I receptor (IGF-IR or IGF-1R). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production.
    Type: Application
    Filed: December 27, 2019
    Publication date: November 19, 2020
    Inventors: Peter Kufer, Tobias Raum, Roman Kischel, Susanne Mangold, Ralf Lutterbüse, Patrick Hoffmann, Doris Rau, Matthias Klinger, Claudia Blümel
  • Patent number: 10781264
    Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: September 22, 2020
    Assignee: AMGEN RESEARCH (MUNICH) GMBH
    Inventors: Tobias Raum, Markus Münz, Johannes Brozy, Peter Kufer, Patrick Hoffmann, Matthias Friedrich, Benno Rattel, Pamela Bogner, Andreas Wolf, Cornelius Pompe
  • Patent number: 10773034
    Abstract: The present invention relates to an inhaler device for delivering a dose of medicament in dry powder form from a container to a patient in need thereof. The inhaler comprises first and second airflow paths (80, 85) which are arranged such that during inhalation, a capsule (40) having a longitudinal axis and first and second end sections (90, 95) delimiting the capsule on opposing ends located in a capsule chamber (30) performs an oscillating movement in the capsule chamber parallel to its longitudinal axis between first and second sidewall portions (60, 65) of the capsule chamber.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 15, 2020
    Assignee: Presspart Manufacturing Ltd.
    Inventors: Julian Hemy, Richard Turner, Hans-Peter Schmelzer, Hans-Jürgen Neugebauer, Dietmar Schmitz, Stefan Hoffmann, Ameet Sule, Sunita Sule, Matthias Seiler, George Alexander Bostock, Aki Hannu Einari Laakso, Michael Worth
  • Patent number: 10767402
    Abstract: The door check includes a retaining bar (20) which can be connected to one of the two door assembly parts, i.e. the door (8) or the door frame (6), and a retaining housing (13) which can be connected to the other door assembly part. In order to design a door check that allows a vehicle door to be reliably and safely blocked in an automated manner, a threaded bar (50) can be accommodated in an axially movable fashion in a cavity of the retaining bar (20).
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: September 8, 2020
    Assignee: EDSCHA ENGINEERING GMBH
    Inventors: Peter Hoffmann, Gundolf Heinrichs, Torsten Meissner, Matthias Brinker, Heiner Ackers, Dietmar Rehborn
  • Publication number: 20200161273
    Abstract: A method and a device for establishing a wire connection between a first contact surface and at least one further contact surface. A contact end of a wire is positioned in a contact position relative to the first contact surface with a wire guiding tool. Subsequently, a mechanical, electrically conductive connection is established between the first contact surface and the contact end with a first solder material connection, and subsequently the wire guiding tool is moved to the further contact surface thus forming a wire section and establishing a further mechanical, electrically conductive connection between the wire section end and the further contact surface with a further solder material connection.
    Type: Application
    Filed: March 15, 2018
    Publication date: May 21, 2020
    Inventors: ANDREJ KOLBASOW, JAN HOFFMANN, MATTHIAS FETTKE
  • Publication number: 20200095319
    Abstract: The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.
    Type: Application
    Filed: September 27, 2019
    Publication date: March 26, 2020
    Inventors: Peter Kufer, Tobias Raum, Roman Kischel, Ralf Lutterbüse, Patrick Hoffmann, Matthias Klinger, Doris Rau, Susanne Mangold
  • Publication number: 20200048357
    Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: April 2, 2019
    Publication date: February 13, 2020
    Inventors: Tobias Raum, Markus Münz, Johannes Brozy, Peter Kufer, Patrick Hoffmann, Matthias Friedrich, Benno Rattel, Pamela Bogner, Andreas Wolf, Cornelius Pompe
  • Publication number: 20190359620
    Abstract: The invention relates to new substituted heteroaryls of formula 1 wherein A is selected from the group consisting of N and CH D is selected from the group consisting of CH, N, NH, S and O, E is selected from the group consisting of C and N, T is selected from the group consisting of C and N, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
    Type: Application
    Filed: August 8, 2019
    Publication date: November 28, 2019
    Inventors: Georg DAHMANN, Matthias HOFFMANN, Jasna KLICIC BADOUX, David James LAMB, Clive MCCARTHY, Spencer Charles R. NAPIER, Karen PARRISH, John SCOTT, Jennifer L. Swantek FITZGERALD, Edward WALKER
  • Patent number: 10456535
    Abstract: The present invention relates to an inhaler device for delivering a dose of medicament in dry powder form from a container to a patient in need thereof. The inhaler comprises a swirl chamber in which particles of the medicament entrained in an airflow swirl upon inhalation thereby breaking up the agglomerates into finest dispersed powder.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: October 29, 2019
    Assignee: Presspart Manufacturing Ltd.
    Inventors: Julian Hemy, Richard Turner, Hans-Peter Schmelzer, Dietmar Schmitz, Stefan Hoffmann, Ameet Sule, Sunita Sule, Matthias Seiler, George Alexander Bostock, Aki Hannu Einari Laakso, Michael Worth, Matthew Schumann
  • Publication number: 20190285637
    Abstract: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Applicant: Adelaide Research & Innovation Pty Ltd
    Inventors: Peter Hoffmann, Megan Penno, Matthias Robert Walter Ernst
  • Publication number: 20190217678
    Abstract: A compensating method is provided for avoiding a bouncing movement of a wheel of a motor vehicle. The motor vehicle comprises an unsprung mass (m) that is attached in a movable manner to a sprung mass, wherein the unsprung mass (m) comprises the wheel, and an actuator that is embodied so as to apply a force (K) between the sprung mass and the unsprung mass (m). During a movement of the unsprung mass (m) relative to the sprung mass in an application of force by means of the open loop control of the actuator by the method, a force (K) is applied between the sprung mass and the unsprung mass (m) so as to damp the movement. A motor vehicle implementing the method is also provided.
    Type: Application
    Filed: January 10, 2019
    Publication date: July 18, 2019
    Applicant: FORD GLOBAL TECHNOLOGIES, LLC
    Inventors: Marcus KALABIS, Martin SAEGER, Michael SEEMANN, Felix WEINREICH, Simon BAALES, Alex FISCHER, Matthias DEHMEL, Uwe HOFFMANN
  • Patent number: 10343373
    Abstract: A coated composite component includes, in this order, a composite component, a fluorine-containing film and/or a fluorine-containing woven fabric, knitted fabric or crocheted fabric, and a tear-off fabric. A method for producing a coated composite component including, in this order, a composite component, a fluorine-containing film and/or a fluorine-containing woven fabric, knitted fabric or crocheted fabric, and a tear-off fabric.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: July 9, 2019
    Assignee: Airbus Defence and Space GmbH
    Inventors: Thomas Koerwien, Michael Hoffmann, Robert Meissner, Helmut Wehlan, Andreas Roessmann, Jens Holtmannspoetter, Sebastian Heckner, Thomas Meer, Matthias Geistbeck
  • Patent number: 10345309
    Abstract: The present invention provides biological markers associated with gastric cancer. In particular, the present invention provides a method of diagnosing gastric cancer (GC) in a subject, the method including: measuring an expression level of one or more proteins in the subject, wherein the one or more proteins are selected from the group consisting of vitamin D binding protein (VDBP), clusterin, insulin like growth factor binding protein complex acid labile subunit (IGFALS), and afamin; comparing the expression level of the or each protein in the subject to a reference expression level for the or each protein; and diagnosing GC in the subject on the basis of the comparison.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: July 9, 2019
    Assignee: Adelaide Research & Innovation Pty Ltd
    Inventors: Peter Hoffmann, Megan Penno, Matthias Robert Walter Ernst
  • Publication number: 20190169310
    Abstract: The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain anti-body molecule.
    Type: Application
    Filed: June 27, 2018
    Publication date: June 6, 2019
    Inventors: Peter Kufer, Tobias Raum, Roman Kischel, Ralf Lutterbüse, Patrick Hoffmann, Doris Rau, Susanne Mangold, Matthias Klinger, Evelyne Schaller, Susanne Hausmann, Petra Fluhr, Carola Steiger
  • Patent number: 10301391
    Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3? chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 28, 2019
    Assignees: AMGEN RESEARCH (MUNICH) GMBH, AMGEN INC.
    Inventors: Tobias Raum, Markus Münz, Johannes Brozy, Peter Kufer, Patrick Hoffmann, Matthias Friedrich, Benno Rattel, Pamela Bogner, Andreas Wolf, Cornelius Pompe
  • Patent number: 10235753
    Abstract: A method for automatic recognition of at least one anatomical landmark in a hollow organ of a patient is provided. The method includes providing an image dataset of the hollow organ, establishing or providing a three-dimensional mesh of a surface of the hollow organ from the image dataset, and determining a centerline of the mesh by skeletization. At least one feature is determined for each of a plurality of points on the centerline. A classifier pre-trained on the at least one feature is used for detecting candidates for the at least one anatomical landmark from the plurality of points. The candidates are grouped together with a distance from one another below a threshold. At least one specification determined from the anatomy of the hollow organ is used for confirming or rejecting the candidates for the at least one anatomical landmark. One or more candidates are defined as an anatomical landmark.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: March 19, 2019
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Matthias Hoffmann, Norbert Strobel
  • Patent number: 10155751
    Abstract: The invention relates to new substituted heteroaryls of formula 1 or of formula 1? wherein A is either N or CH, wherein R2 is selected from the group consisting of —C1-3-alkyl, —C1-3-haloalkyl, F, Br, Cl, wherein Y is selected from —O— or —CH2—, and wherein R3 is defined as in claim 1, and the pharmaceutically acceptable salts thereof, and the use of these aforementioned compounds for the treatment of diseases such as asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: December 18, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Hoffmann, Georg Dahmann, Christian Gnamm, Daniel Robert Fandrick, John Scott, Clive McCarthy