Patents by Inventor Matthias J. G. Ottenberg

Matthias J. G. Ottenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8980200
    Abstract: Disclosed is a nozzle assembly that is compact in size and that uses plastic tubing as an injection needle. Standard plastic fittings are utilized, which are inexpensive and widely available. The nozzle assembly has a simple construction and can be easily assembled and disassembled in a few minutes by a user. Cleaning and/or replacement of parts is inexpensive. Plastic tubing can be used as an injection needle that has superior qualities over commonly used stainless steel injection needles. Flexure of the injection needle tubing is prevented because of the compact size of the nozzle cavity.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 17, 2015
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Daniel N. Fox, Matthias J. G. Ottenberg, Kevin P. Raley, Nathan Michael Gaskill-Fox
  • Patent number: 8619370
    Abstract: Disclosed is an optical combiner for combining multiple laser beams in a flow cytometer. A dichroic beam combiner is used to combine a second laser beam with a first laser beam so that the two beams are collinear. A beam size adjuster is utilized to adjust the size and convergence/divergence of the second laser beam so that both laser beams focus in a vertical direction at the same location on a stream in the flow cytometer. A cylindrical lens with a vertically oriented axis in the focusable beam shaping optics can also be adjusted to adjust the location of the focus point of the two beams in the horizontal direction. Alignment is maintained with the opto-mechanical adjustments made on one laser beam relative to the other laser beam path. Additional beams can also be added to the optical path.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: December 31, 2013
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Susan Hunter, Daniel N. Fox, Tidhar Sadeh, Matthias J. G. Ottenberg, Kevin P. Raley
  • Publication number: 20130343965
    Abstract: Disclosed is a nozzle assembly that is compact in size and that uses plastic tubing as an injection needle. Standard plastic fittings are utilized, which are inexpensive and widely available. The nozzle assembly has a simple construction and can be easily assembled and disassembled in a few minutes by a user. Cleaning and/or replacement of parts is inexpensive. Plastic tubing can be used as an injection needle that has superior qualities over commonly used stainless steel injection needles. Flexure of the injection needle tubing is prevented because of the compact size of the nozzle cavity.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 26, 2013
    Inventors: Daniel N. Fox, Matthias J.G. Ottenberg, Kevin P. Raley, Nathan Michael Gaskill-Fox
  • Patent number: 8557587
    Abstract: Disclosed is a self-tuning flow cytometer that uses a mathematical model to perform sort decisions that is based upon the biological response of the particular types of cells that are being sorted. In one embodiment, statistical calculations of the likelihood of an event belonging to a certain population are used to make the sort decisions. Automated self-tuning processes are used to optimize the operating parameters of the flow cytometer to achieve a selected purity with higher yield at optimal sorting speeds. The fully automated processes minimize user input and allows the user to select a desired purity while maximizing yield.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: October 15, 2013
    Assignee: XY, LLC
    Inventors: Daniel N. Fox, George C. Malachowski, Matthias J. G. Ottenberg, Tidhar Sadeh
  • Publication number: 20120270204
    Abstract: A method for magnetic sorting of mammalian sperm cells having damaged membranes is described. In an embodiment of the invention, carboxyl-group functionalized magnetic particles are conjugated to propidium iodide, the resulting composition is mixed with a sample of sperm cells, and sperm cells bound to magnetic particles are separated by magnetic-activated cell sorting.
    Type: Application
    Filed: February 16, 2012
    Publication date: October 25, 2012
    Inventors: Daniel N. Fox, Tidhar Sadeh, Matthias J.G. Ottenberg, Kristie M. Melnik, John L. Schenk
  • Publication number: 20120105967
    Abstract: Disclosed is an optical combiner for combining multiple laser beams in a flow cytometer. A dichroic beam combiner is used to combine a second laser beam with a first laser beam so that the two beams are collinear. A beam size adjuster is utilized to adjust the size and convergence/divergence of the second laser beam so that both laser beams focus in a vertical direction at the same location on a stream in the flow cytometer. A cylindrical lens with a vertically oriented axis in the focusable beam shaping optics can also be adjusted to adjust the location of the focus point of the two beams in the horizontal direction. Alignment is maintained with the opto-mechanical adjustments made on one laser beam relative to the other laser beam path. Additional beams can also be added to the optical path.
    Type: Application
    Filed: May 3, 2011
    Publication date: May 3, 2012
    Inventors: Susan Hunter, Daniel N. Fox, Tidhar Sadeh, Matthias J.G. Ottenberg, Kevin P. Raley
  • Publication number: 20110010144
    Abstract: Disclosed is a self-tuning flow cytometer that uses a mathematical model to perform sort decisions that is based upon the biological response of the particular types of cells that are being sorted. In one embodiment, statistical calculations of the likelihood of an event belonging to a certain population are used to make the sort decisions. Automated self-tuning processes are used to optimize the operating parameters of the flow cytometer to achieve a selected purity with higher yield at optimal sorting speeds. The fully automated processes minimize user input and allows the user to select a desired purity while maximizing yield.
    Type: Application
    Filed: January 6, 2010
    Publication date: January 13, 2011
    Inventors: Daniel N. Fox, George C. Malachowski, Matthias J.G. Ottenberg, Tidhar Sadeh
  • Patent number: 6746873
    Abstract: A flow cytometry system is disclosed for oscillating the exterior of a flow cytometer nozzle. Oscillating the exterior of a flow cytometer nozzle at selected oscillations or a sweeping range of oscillations disintegrates particles and gas entrapped within the flow cytometer nozzle. Adherents absorbed to the exterior of the flow cytometer nozzle may also be removed. An energy source (1) serves to generate a selected oscillation or range of oscillations. The energy source (1) is connected to a flexible transfer element (2) which conducts the electrical signals to an oscillation system (3). The oscillation system (3) turns the electrical energy from the energy source (1) into mechanical oscillations and is connected to a portable device (4) which disintegrates particles, dislocates gas within the flow cytometer nozzle and cleans the exterior of the flow cytometer aperture.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: June 8, 2004
    Assignees: XY, Inc., DakoCytomation Colorado, Inc., Colorado State University Research Foundation
    Inventors: Kristopher S. Buchanan, Lisa Herickhoff, George Seidel, George C. Malachowski, Matthias J. G. Ottenberg, Douglas H. Ferguson