Patents by Inventor Matthias Jöhnck
Matthias Jöhnck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10617975Abstract: The present invention refers to a method for the separation of peptide aggregates and fragments from solutions containing target peptide.Type: GrantFiled: November 18, 2015Date of Patent: April 14, 2020Assignee: MERCK PATENT GMBHInventors: Romas Skudas, Klaus Adrian, Bianca Edelmann, Matthias Joehnck
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Patent number: 10457720Abstract: The present invention refers to a method for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies.Type: GrantFiled: February 18, 2015Date of Patent: October 29, 2019Assignee: Merck Patent GmbHInventors: Romas Skudas, Matthias Joehnck, Bianca Edelmann, Simon Braun, Mikhail Kozlov, Matthew T. Stone, Kevin Galipeau
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Publication number: 20180346510Abstract: The present invention relates to a method for an improved preparative separation of proteins, particularly monoclonal antibodies (mAB) from its associated charge variants (e. g. acidic and basic monomers), glycosylation variants, and/or soluble size variants (e. g. aggregates, monomers, ? fragments, ¾ fragments, antigen binding fragments (Fab) and crystallisable fragments (Fc).Type: ApplicationFiled: October 28, 2016Publication date: December 6, 2018Applicant: MERCK PATENT GMBHInventor: Matthias JOEHNCK
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Publication number: 20180327447Abstract: Disclosed are improved preparative (>5 g/l) protein separations, which are achieved by combining salt and pH gradients for preparative protein separations in combination with the development of a preparative step elution protein separation based on data generated by combined salt-pH gradient runs.Type: ApplicationFiled: October 28, 2016Publication date: November 15, 2018Applicant: Merck Patent GmbHInventor: Matthias JOEHNCK
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Patent number: 9975920Abstract: The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a crosslinked polyvinylether results in especially high yields of the target molecule.Type: GrantFiled: August 10, 2015Date of Patent: May 22, 2018Assignee: MERCK PATENT GMBHInventors: Annika Aldinger, Achim Schwaemmle, Matthias Joehnck, Dirk Mueller, Marc Mazur
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Publication number: 20170340989Abstract: The present invention refers to a method for the separation of peptide aggregates and fragments from solutions containing target peptide.Type: ApplicationFiled: November 18, 2015Publication date: November 30, 2017Applicant: MERCK PATENT GMBHInventors: Romas SKUDAS, Klaus ADRIAN, Bianca EDELMANN, Matthias JOEHNCK
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Publication number: 20170073394Abstract: The present invention refers to a method for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies.Type: ApplicationFiled: February 18, 2015Publication date: March 16, 2017Applicant: Merck Patent GmbHInventors: Romas SKUDAS, Matthias JOEHNCK, Bianca EDELMANN, Simon BRAUN, Mikhail KOZLOV, Matthew T. STONE, Kevin GALIPEAU
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Patent number: 9303098Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.Type: GrantFiled: May 5, 2009Date of Patent: April 5, 2016Assignee: MERCK PATENT GMBHInventor: Matthias Joehnck
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Publication number: 20160046664Abstract: The present invention relates to the purification of target molecules like immunoglobulins from plasma. The use of a certain type of ion exchanger based on a crosslinked polyvinylether results in especially high yields of the target molecule.Type: ApplicationFiled: August 10, 2015Publication date: February 18, 2016Applicant: MERCK PATENT GMBHInventors: Annika ALDINGER, Achim SCHWAEMMLE, Matthias JOEHNCK, Dirk MUELLER, Marc MAZUR
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Patent number: 8765897Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerization from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: GrantFiled: November 17, 2010Date of Patent: July 1, 2014Assignee: Merck Patent GmbHInventors: Matthias Joehnck, Eckhard Sabrowskii
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Publication number: 20140155565Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: ApplicationFiled: February 5, 2014Publication date: June 5, 2014Applicant: Merck Patent GmbHInventors: Matthias JOEHNCK, Eckhard SABROWSKII
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Patent number: 8735496Abstract: The present invention relates to a process for the production of the largest possible spherical, monodisperse polyvinylpyrrolidone (PVP) seed particles in the micron range by dispersion polymerisation. The particles obtained in this way represent novel starting materials for the production of macroporous polymer particles, which can in turn be employed in preparative and analytical chromatography for protein preparation. They can also be employed as base material for further reactions. The novel process for the polymerisation of N-vinylpyrrolidone, which is inexpensive to carry out, gives particles having optimised quantities, such as monodispersity, sphericity and particle diameter, which can be employed in further reactions and have advantageous, in particular improved, properties for use in chromatographic separation methods.Type: GrantFiled: April 27, 2010Date of Patent: May 27, 2014Assignee: Merck Patent GmbHInventors: Matthias Joehnck, Daniel Scheid
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Publication number: 20120295992Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.Type: ApplicationFiled: August 1, 2012Publication date: November 22, 2012Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNGInventor: Matthias JOEHNCK
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Publication number: 20120053254Abstract: The present invention relates to a process for the production of the largest possible spherical, monodisperse polyvinylpyrrolidone (PVP) seed particles in the micron range by dispersion polymerisation. The particles obtained in this way represent novel starting materials for the production of macroporous polymer particles, which can in turn be employed in preparative and analytical chromatography for protein preparation. They can also be employed as base material for further reactions. The novel process for the polymerisation of N-vinylpyrrolidone, which is inexpensive to carry out, gives particles having optimised quantities, such as monodispersity, sphericity and particle diameter, which can be employed in further reactions and have advantageous, in particular improved, properties for use in chromatographic separation methods.Type: ApplicationFiled: April 27, 2010Publication date: March 1, 2012Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Matthias Joehnck, Daniel Scheid
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Patent number: 7951885Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: GrantFiled: June 8, 2006Date of Patent: May 31, 2011Assignee: Merck Patent GmbHInventors: Matthias Joehnck, Eckhard Sabrowskii
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Publication number: 20110091727Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: ApplicationFiled: November 17, 2010Publication date: April 21, 2011Inventors: Matthias Joehnck, Eckhard Sabrowskii
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Publication number: 20110073547Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.Type: ApplicationFiled: May 5, 2009Publication date: March 31, 2011Applicant: MERCK PATENT GESELLSCHAFTInventor: Matthias Joehnck
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Publication number: 20080210615Abstract: The present invention relates to a hydrophilic crosslinked polymer, preferably in the form of porous particles, and to the preparation and use thereof. The polymer according to the invention is produced by polymerisation from chain-forming hydrophilic vinyl ethers and crosslinking, preferably heterocyclic divinyl ethers.Type: ApplicationFiled: June 8, 2006Publication date: September 4, 2008Inventors: Matthias Joehnck, Eckhard Sabrowskii
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Publication number: 20050158209Abstract: A microcomponent connection system (1) having an accomodation device for plate-shaped microcomponents (7) has a connection block (2) and a lifting device (6), by means of which the microcomponent (7) and the connection block (2) can be pressed against one another. The connection block (2) has electrical and fluid line connections (8, 9) and optical line connections (16), each of which projects in a sprung or spring-mounted manner on the underside of the connection block (2). In order to connect the microcomponent (7) to the associated line connections (8, 9, 16), the microcomponent (7) is pressed by the lifting device (6) in the direction of the connection block (2) against the electrical line connections (8) or fluid line connections (9) designed as electrically conducting spring tongues or as hollow rams (10), or optical line connections (16).Type: ApplicationFiled: February 10, 2003Publication date: July 21, 2005Applicant: Merck Patent GmbHInventors: Renate Bender, Gunter Brenner, Thomas Greve, Matthias Joehnck, Bernd Stanislawski, Michael Schmelz, Sigrid Sturmfels
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Patent number: 6838156Abstract: The invention relates to a method for linking two adjacent plastic work pieces (2, 3). The inventive method is characterized in that the intended contact zone (K) of at least one of the two work pieces (2) with which the latter adjoins to the other work piece (3) is at least partially subjected to a high-energy radiation to such an extent that the glass transition temperature is reduced in a marginal zone (R). The two work pieces (2, 3) are brought in the desired position relative to each other. For establishing the connection of the two work pieces (2, 3) at least the marginal zone (R) modified by the previous radiation process is heated at least in its surface area to a temperature that is higher than the glass transition temperature of the marginal zone (R) modified by the radiation process but lower than the glass transition temperature of the zones of the work pieces (2, 3) that have not been modified.Type: GrantFiled: March 29, 2000Date of Patent: January 4, 2005Assignee: Aclara Biosciences, Inc.Inventors: Andreas Neyer, Matthias Jöhnck