Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a neural network that is configured to process an input image to generate a network output for the input image. In one aspect, a method comprises, at each of a plurality of training steps: obtaining a plurality of training images for the training step; obtaining, for each of the plurality of training images, a respective target output; and selecting, from a plurality of image patch generation schemes, an image patch generation scheme for the training step, wherein, given an input image, each of the plurality of image patch generation schemes generates a different number of patches of the input image, and wherein each patch comprises a respective subset of the pixels of the input image.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for object detection. In one aspect, a method comprises: obtaining: (i) an image, and (ii) a set of one or more query embeddings, wherein each query embedding represents a respective category of object; processing the image and the set of query embeddings using an object detection neural network to generate object detection data for the image, comprising: processing the image using an image encoding subnetwork of the object detection neural network to generate a set of object embeddings; processing each object embedding using a localization subnetwork to generate localization data defining a corresponding region of the image; and processing: (i) the set of object embeddings, and (ii) the set of query embeddings, using a classification subnetwork to generate, for each object embedding, a respective classification score distribution over the set of query embeddings.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing images using self-attention based neural networks. One of the methods includes obtaining one or more images comprising a plurality of pixels; determining, for each image of the one or more images, a plurality of image patches of the image, wherein each image patch comprises a different subset of the pixels of the image; processing, for each image of the one or more images, the corresponding plurality of image patches to generate an input sequence comprising a respective input element at each of a plurality of input positions, wherein a plurality of the input elements correspond to respective different image patches; and processing the input sequences using a neural network to generate a network output that characterizes the one or more images, wherein the neural network comprises one or more self-attention neural network layers.

Abstract: The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for object detection. In one aspect, a method comprises: obtaining: (i) an image, and (ii) a set of one or more query embeddings, wherein each query embedding represents a respective category of object; processing the image and the set of query embeddings using an object detection neural network to generate object detection data for the image, comprising: processing the image using an image encoding subnetwork of the object detection neural network to generate a set of object embeddings; processing each object embedding using a localization subnetwork to generate localization data defining a corresponding region of the image; and processing: (i) the set of object embeddings, and (ii) the set of query embeddings, using a classification subnetwork to generate, for each object embedding, a respective classification score distribution over the set of query embeddings.

Abstract: The present invention relates to compounds of the Formula (1) and pharmaceutically acceptable salts thereof, wherein M3+ is as defined herein, and their use as cancer diagnostic or imaging agents.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing images using self-attention based neural networks. One of the methods includes obtaining one or more images comprising a plurality of pixels; determining, for each image of the one or more images, a plurality of image patches of the image, wherein each image patch comprises a different subset of the pixels of the image; processing, for each image of the one or more images, the corresponding plurality of image patches to generate an input sequence comprising a respective input element at each of a plurality of input positions, wherein a plurality of the input elements correspond to respective different image patches; and processing the input sequences using a neural network to generate a network output that characterizes the one or more images, wherein the neural network comprises one or more self-attention neural network layers.

Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.

Abstract: The present invention includes a vaccine comprising a nucleic acid comprising (a) a nucleotide sequence encoding a rabies virus nucleoprotein (N) or a portion thereof and (b) a nucleotide sequence encoding a glycoprotein (G) (e.g., a RABV glycoprotein, a MOKV glycoprotein, or a chimeric MOKV/RABY glycoprotein), or a portion thereof positioned immediately 3? to the nucleoprotein (N) gene sequence.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for object detection. In one aspect, a method comprises: obtaining: (i) an image, and (ii) a set of one or more query embeddings, wherein each query embedding represents a respective category of object; processing the image and the set of query embeddings using an object detection neural network to generate object detection data for the image, comprising: processing the image using an image encoding subnetwork of the object detection neural network to generate a set of object embeddings; processing each object embedding using a localization subnetwork to generate localization data defining a corresponding region of the image; and processing: (i) the set of object embeddings, and (ii) the set of query embeddings, using a classification subnetwork to generate, for each object embedding, a respective classification score distribution over the set of query embeddings.

Abstract: The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.

Abstract: The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.

Abstract: In a method for insulating a coil winding of an active part of a rotating electric machine, the active part is impregnated with an insulating resin in a tub-like impregnation container by vacuum pressure impregnation. The active part is held in the impregnation container, after impregnation with the insulating resin, completely submerged in the insulating resin. The impregnation container together with the active part is introduced into a baking oven, and the active part is set in the insulating resin in rotation about a longitudinal axis of the active part. While the active part is rotating, the insulating resin is purged from the impregnation container and then the oven temperature is increased to a predetermined baking temperature which is maintained for a predetermined baking period. Rotation of the active part is terminated after expiration of the baking period.

Abstract: The present invention includes a vaccine comprising a SARS-CoV-2 spike protein (S) or portion thereof, and methods of use thereof.

Abstract: A computer-implemented method (110) for designing at least one shaped body (112), a computer-implemented method (138) for designing a manufacturing process for manufacturing at least one shaped body (112), a designing system (152) for designing at least one shaped body (112) and a manufacture-designing system for designing a manufacturing process for manufacturing at least one shaped body (112).

Abstract: The present invention relates to a ligand-SIF A-chelator conjugate, comprising, within in a single molecule three separate moieties: (a) one or more ligands which are capable of binding to a disease-relevant target molecule, (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom, and (c) one or more chelating groups, optionally containing a chelated nonradioactive or radioactive cation.

Abstract: In a method for insulating a coil winding of an active part of a rotating electric machine, the active part is impregnated with an insulating resin in a tub-like impregnation container by vacuum pressure impregnation. The active part is held in the impregnation container, after impregnation with the insulating resin, completely submerged in the insulating resin. The impregnation container together with the active part is introduced into a baking oven, and the active part is set in the insulating resin in rotation about a longitudinal axis of the active part. While the active part is rotating, the insulating resin is purged from the impregnation container and then the oven temperature is increased to a predetermined baking temperature which is maintained for a predetermined baking period. Rotation of the active part is terminated after expiration of the baking period.

Abstract: A branched carboxylic acid functional polyester resin P is described herein along with thermosetting powder coating compositions (PCC A) comprising a binder K, the binder K comprising the polyester resin P and a crosslinker X. The invention further relates to a cured PCC A. In addition, processes for making said PCC A and processes for coating an article with said PCC A are described as well as articles having coated thereon the PCC A and an articles having coated and cured thereon the PCC A.

Abstract: The present invention relates to an iron-based alloy powder containing non-spherical particles wherein the alloy comprises the elements Fe (iron), Cr (chrome) and Mo (molybdenum), and at least 40% of the total amount of particles have a non-spherical shape. In said iron-based alloy powder, Cr is present at 10.0 wt. % to 18.3 wt. %, Mo is present at 0.5 wt. % to 2.5 wt. %, C is present at 0 to 0.30 wt. %, Ni is present at 0 to 4.0 wt. %, Cu is present at 0 to 4.0 wt. %, Nb is present at 0 to 0.7 wt. %, Si is present at 0 to 0.7 wt. % and N is present at 0 to 0.20 wt. %, the balance up to 100 wt. % is Fe.