Abstract: A method and kit is described for the detection of a biomarker in a sample, by light scattering microscopy. The invention is particularly useful for the detection of low abundance biomarker in complex samples, and is suitable for use in a point of care setting. In an embodiment, the method of the invention describes detection of a biomarker in a sample using mass photometry.

Abstract: A control system for a medical installation, wherein the control system is configured to control a motorized movement of an installation component. The control system includes a control path and a protection path. The control path is configured to control the motorized movement. The protection path is independent of the control path and configured to monitor the control path with regard to compliance with a safety criterion for the motorized movement. The protection path includes at least one freely programmable microcontroller.

Abstract: A method for communication between and/or determination of the movement of at least two vehicles 2a, b, c travelling in succession by means of a communication arrangement 4, wherein the communication arrangement 4 has at least one first communication apparatus 3a for arrangement on a first vehicle 2a and at least one second communication apparatus 3b for arrangement on a second vehicle 2b, is proposed, in which a signal is transmitted via a transmission path between the communication apparatuses 3a, b, c, wherein a main transmission link H of the transmission path runs at least beneath the first and/or second vehicle 2a, b and/or in which the determination of movement is carried out on the basis of the propagation time and/or propagation time differences.

Abstract: An apparatus for measuring, inspecting and/or processing objects is provided. The apparatus has a mobile platform for moving the apparatus through a region in space and a kinematic system attached to the mobile platform. An instrument head is fitted to the kinematic system. The apparatus furthermore comprises a controller configured to determine a first estimate of a pose of a target object on the basis of an image from a camera of the apparatus and a digital representation of the target object, to control the mobile platform on the basis of the first estimate, to move toward the target object, to determine a second estimate, in particular a more accurate estimate, of the pose of the target object on the basis of signals from at least one sensor of the apparatus and to control the kinematic system to position the instrument head on the target object on the basis of the second estimate.

Abstract: An object receiving container may receive an object which is examinable, analyzable and/or processable at cryo-temperatures. An object holding system may comprise an object receiving container. A beam apparatus or an apparatus for processing an object may comprise an object receiving container or an object holding system. An object may be examined, analyzed and/or processed using an object receiving container or an object holding system. The object receiving container may comprise a first container unit, a cavity for receiving the object, a second container unit, which is able to be brought into a first position and/or into a second position relative to the first container unit, and at least one fastening device which is arranged at the first container unit or at the second container unit for arranging the object receiving container at a holding device.

Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.

Abstract: The present disclosure relates to a method of medical calibration, including the method steps of: capturing an image representation of a medical marker and of a medical instrument connected therewith; determining a spatial pose of the medical marker on the basis of the image representation; determining a first position of a tracking point of the medical instrument on the basis of the determined spatial pose and on the basis of information relating to a spatial pose relationship between medical marker and tracking point, and determining a second position of the tracking point on the basis of the captured image representation; determining a deviation between the first position and the second position; adjusting the information relating to the spatial pose relationship between medical marker and tracking point on the basis of the determined deviation.

Abstract: The present disclosure relates to a method of medical navigation including the method steps of: capturing a first image representation of a medical marker in a first perspective; capturing a second image representation of the medical marker in a second perspective; determining a three-dimensional representation of the medical marker on the basis of the first image representation and the second image representation; capturing a third image representation of the medical marker; and determining a spatial pose of the medical marker on the basis of a comparison of the third image representation and the three-dimensional representation of the medical marker. The present disclosure further relates to a medical navigation system, to a computer program and to the use of a three-dimensional representation of a medical marker for registering a medical instrument, a patient and/or a piece of medical equipment.

Abstract: An object receiving container may receive an object which is examinable, analyzable and/or processable at cryo-temperatures. An object holding system may comprise an object receiving container. A beam apparatus or an apparatus for processing an object may comprise an object receiving container or an object holding system. An object may be examined, analyzed and/or processed using an object receiving container or an object holding system. The object receiving container may comprise a first container unit, a cavity for receiving the object, a second container unit, which is able to be brought into a first position and/or into a second position relative to the first container unit, and at least one fastening device which is arranged at the first container unit or at the second container unit for arranging the object receiving container at a holding device.

Abstract: The application discloses a method and apparatus for imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one coherent light source, the sample being held at a sample location comprising an interface having a refractive index change, illuminating the sample with illuminating radiation to generate a backpropagating signal from the sample comprising light reflected at the interface and light scattered by the sample, splitting the backpropagating signal into first and second signals, modifying the second signal using a modifying element such that the second signal differs from the first signal, directing the first and second signals onto first and second detectors to generate, respectively, first and second images and comparing, by a processor, the first and second images to determine one or more characteristics of the sample.

Abstract: The invention relates to a flexible electrode (8) made of a metal base material (10) with a coating (18) made of polycrystalline doped electrically conductive diamond and an intermediate layer (20) between the base material (10) and the coating (18), wherein the base material (10) is in the form of a needle or wire, wherein at least one circumferential, circular or spiral groove (12) is formed in the base material (10) about a longitudinal axis (17) of the base material (10).

Abstract: A method for communication between and/or determination of the movement of at least two vehicles 2a, b, c travelling in succession by means of a communication arrangement 4, wherein the communication arrangement 4 has at least one first communication apparatus 3a for arrangement on a first vehicle 2a and at least one second communication apparatus 3b for arrangement on a second vehicle 2b, is proposed, in which a signal is transmitted via a transmission path between the communication apparatuses 3a, b, c, wherein a main transmission link H of the transmission path runs at least beneath the first and/or second vehicle 2a, b and/or in which the determination of movement is carried out on the basis of the propagation time and/or propagation time differences.

Abstract: Sensor data are received from a multiplicity of sensors, wherein the multiplicity of sensors image a common scene using a multiplicity of measurement modalities. For each sensor of the multiplicity of sensors, at least one corresponding feature is determined in the respective sensor data and corresponding performance specification data are also obtained. In addition, mutual correspondence analysis between the features of the sensor data is carried out taking into account the corresponding performance specification data. Sensor fusion is also carried out on the basis of the correspondence analysis.

Abstract: An odorant and flavoring formulation for topical application comprising, as matrix former, a mixture of at least one water-insoluble polymer from the group of homo- or co-polymers of C1-C4-carboxylic acid vinyl esters and at least one water-soluble polymer from the group of homo- or copolymers of N-vinyllactams.

Abstract: The use of powder-form, crosslinked, water-insoluble, low-swelling polyacrylates as disintegrants for solid pharmaceutical dosage forms.

Abstract: An object receiving container may receive an object which is examinable, analyzable and/or processable at cryo-temperatures. An object holding system may comprise an object receiving container. A beam apparatus or an apparatus for processing an object may comprise an object receiving container or an object holding system. An object may be examined, analyzed and/or processed using an object receiving container or an object holding system. The object receiving container may comprise a first container unit, a cavity for receiving the object, a second container unit, which is able to be brought into a first position and/or into a second position relative to the first container unit, and at least one fastening device which is arranged at the first container unit or at the second container unit for arranging the object receiving container at a holding device.

Abstract: An acoustic sensor, including a carrier element, a diaphragm element, which is situated on a first side of the carrier element, and an electroacoustic transducer, which is situated on a side of the diaphragm element facing the carrier element and is configured to induce at least a region of the diaphragm element to vibrate; at at least an edge region, the diaphragm element having a retaining region, which extends in the direction of the carrier element and embraces a subregion of the carrier element.

Abstract: A sound transducer, including a diaphragm and at least one piezoactuator, which is situated in an operative connection to the diaphragm, the oscillation direction of the piezoactuator being situated at least generally perpendicularly in relation to the oscillation direction of the diaphragm, at least one lever element being situated between the diaphragm and the piezoactuator, which connects the diaphragm to the piezoactuator and is designed to convert oscillations of the piezoactuator into oscillations of the diaphragm and vice versa, and a clamp connection being formed between the at least one lever element, and the piezoactuator. The clamp connection is formed between an end face of the piezoactuator situated in the oscillation direction of the piezoactuator and the at least one lever element, and the piezoactuator is situated under an axial pre-tension force extending in the oscillation direction of the piezoactuator by the at least one lever element.

Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.

Abstract: An acoustic sensor including an electroacoustic transducer and an electrical conductor. The electroacoustic transducer includes a plate-shaped transducer element, which is configured to output an acoustic signal when it is excited by the electrical signal. The electroacoustic transducer furthermore includes a first contacting, which is situated on at least one of the surfaces of the plate-shaped transducer element in such a way that it has at least one portion which ends flush with the outer circumference of the first or second surface of the plate-shaped transducer element, or extends at least partially outside the outer circumference of the first or second surface of the plate-shaped transducer element. The electrical conductor includes a contact area in contact with an outer circumference of the first contacting, the contact area of the electrical conductor being situated in a plane defined by the first surface, outside an area which overlaps with the electroacoustic transducer.