Patents by Inventor Matthias Klugmann

Matthias Klugmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VIRAL VECTORS AND NUCLEIC ACIDS FOR REGULATED GENE THERAPY
    Publication number: 20240076689
    Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.
    Type: Application
    Filed: May 17, 2021
    Publication date: March 7, 2024
    Inventors: John Park, Philipp MÜLLER, Sebastian KREUZ, Benjamin STROBEL, Matthias DÜCHS, Matthias KLUGMANN, Stefan MICHELFELDER, Dragica BLAZEVIC, Romona KRATZER
  • ADENO ASSOCIATED VIRUS BASED GENE THERAPY FOR PHENYLKETONURIA
    Publication number: 20230055020
    Abstract: The present disclosure provides, among other things, a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 capsid and a codon-optimized sequence encoding a human phenylalanine hydroxylase (PAH) enzyme. The disclosure also provides a method of treating a subject having phenylketonuria (PKU), comprising administering to the subject in need thereof a recombinant adeno-associated vims (rAAV) vector comprising an AAV8 capsid, and a promoter operably linked to a nucleic acid sequence that encodes PAH, and wherein administering results in a decrease in phenylalanine level in the subject.
    Type: Application
    Filed: January 15, 2021
    Publication date: February 23, 2023
    Inventors: Matthias KLUGMANN, Hanspeter ROTTENSTEINER, Franziska HORLING, Johannes LANGLER
  • ADENO-ASSOCIATED VIRUS VECTORS BASED GENE THERAPY FOR HEREDITARY ANGIOEDEMA
    Publication number: 20230043051
    Abstract: The present disclosure provides, among other things, a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 capsid and a codon-optimized SERPING1 sequence encoding a human C1-esterase inhibitor. The disclosure also provides a method of treating a subject having Hereditary angioedema (HAE), comprising administering to the subject in need thereof a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 capsid, and codon-optimized SERPING1 sequences encoding a human C1-esterase inhibitor.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 9, 2023
    Inventors: Matthias Klugmann, Franziska Horling, Johannes Lengler, Patrice Douillard, Friedrich Scheiflinger, Hanspeter Rottensteiner, Bagirath Gangadharan
  • Method and apparatus for close-field electroporation
    Patent number: 11013917
    Abstract: The present invention relates to improved methods for transfecting one or more cells within a target region with an agent by electroporation. The method comprises exposing one or more cells to the agent and to a close electric field created between an anode or anode array and a cathode or cathode array in the target region for sufficient time to allow at least some of the agent to enter said one or more cells.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: May 25, 2021
    Assignee: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: Gary David Housley, Matthias Klugmann, Jeremy Pinyon
  • METHODS FOR INHIBITING NEURON APOPTOSIS AND NECROSIS
    Publication number: 20170202932
    Abstract: The present invention relates generally to methods for inhibiting neuron apoptosis and necrosis associated with excess glutamate release.
    Type: Application
    Filed: March 23, 2017
    Publication date: July 20, 2017
    Inventors: Gary David HOUSLEY, Youngsoo Kim, Paul Page BERTRAND, Andrew MOORHOUSE, Ann Chi Yan Wong, Amanda Jayne CRAIG, John POWER, Matthias KLUGMANN, Arun KRISHNAN, Renee MORRIS
  • METHOD AND APPARATUS FOR CLOSE-FIELD ELECTROPORATION
    Publication number: 20160129246
    Abstract: The present invention relates to improved methods for transfecting one or more cells within a target region with an agent by electroporation. The method comprises exposing one or more cells to the agent and to a close electric field created between an anode or anode array and a cathode or cathode array in the target region for sufficient time to allow at least some of the agent to enter said one or more cells.
    Type: Application
    Filed: June 23, 2014
    Publication date: May 12, 2016
    Inventors: Gary David Housley, Matthias Klugmann, Jeremy Pinyon
  • METHODS FOR INHIBITING NEURON APOPTOSIS AND NECROSIS
    Publication number: 20150190366
    Abstract: The present invention relates generally to methods for inhibiting neuron apoptosis and necrosis associated with excess glutamate release.
    Type: Application
    Filed: July 5, 2013
    Publication date: July 9, 2015
    Inventors: Gary David Housley, Youngsoo Kim, Paul Page Bertrand, Andrew Moorhouse, Ann Chi Yan Wong, Amanda Jayne Craig, John Power, Matthias Klugmann, Arun Krishnan, Renee Morris