Patents by Inventor Matthias Koerner

Matthias Koerner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11577294
    Abstract: The present disclosure relates to a method for producing a shaped sheet metal component from a billet by means of U O forming, wherein firstly a preform is created by the U-forming and then a final shaping is performed by the O forming to give a final form.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: February 14, 2023
    Assignee: BENTELER AUTOMOBILTECHNIK GMBH
    Inventors: Guenter Fortmeier, Aloys Schroeder, Matthias Koerner, Eugen Seibel, Thomas Henksmeier
  • Patent number: 11358962
    Abstract: The invention relates to small molecule imaging tools, specifically compounds of formula II and to pharmaceutically acceptable acid addition salts thereof, wherein R1-R6 have any of the values defined in the specification.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 14, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Patent number: 11306093
    Abstract: A process for preparing the compound of formula I comprising: a) coupling a compound of formula 2 wherein a leaving group O—SO2—R is selected from the triflate group, the tosylate group, the mesylate group, the besylate group, the nosylate group or the brosylate group, with a suitable boronic acid, a trifluoroborate or a boronic acid ester under argon condition and in the presence of a catalyst and a base in a suitable solvent and then isolating the product as an acid addition salt to afford the compound of formula Ia and b) converting the acid addition salt of formula Ia wherein the acid HX comprises suitable organic or inorganic acids into the compound of formula I by treatment with at least a stoichiometric equivalent of a suitable base.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: April 19, 2022
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Bjoern Bartels, Philipp Cueni, Matthias Koerner, Dieter Muri
  • Patent number: 11141770
    Abstract: The disclosure relates to a method for producing a shaped sheet metal part from a billet by UO forming. First, a preform is created by the U-forming. Then, final forming to give a final form is carried out by the O-forming. The preform has in cross section a maximum width that is smaller than the maximum width of the final form produced after the O-forming.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 12, 2021
    Assignee: BENTELER AUTOMOBILTECHNIK GMBH
    Inventors: Guenter Fortmeier, Thomas Henksmeier, Matthias Koerner, Aloys Schroeder, Eugen Seibel
  • Patent number: 11058781
    Abstract: The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, besides others, beta-amyloid aggregates or alpha-synuclein aggregates.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: July 13, 2021
    Inventors: Luca Gobbi, Henner Knust, Matthias Koerner, Dieter Muri
  • Patent number: 10975073
    Abstract: The invention relates to small molecule imaging tools.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 13, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Patent number: 10633036
    Abstract: The present invention relates to an axle carrier 1 and to a method for the production of the axle carrier 1. The axle carrier 1 has an upper shell 2 from an aluminum die-casting and a lower shell 3 from a fiber composite material. On a ribbed structure of the lower shell 3, an upper end 14 of the reinforcing ribs 9 is preferably configured so as to be widened such that the bearing face between the reinforcing rib 9 and the upper shell 2 is enlarged and, on account thereof, the strength of the axle carrier 1 produced is increased.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: April 28, 2020
    Assignee: BENTELER AUTOMOBILTECHNIK GMBH
    Inventors: Matthias Koerner, Thomas Henksmeier, Guenter Fortmeier, Frank Hoecker, Aloys Schroeder
  • Publication number: 20200114408
    Abstract: The present disclosure relates to a method for producing a shaped sheet metal component from a billet by means of U O forming, wherein firstly a preform is created by the U-forming and then a final shaping is performed by the O forming to give a final form.
    Type: Application
    Filed: September 20, 2019
    Publication date: April 16, 2020
    Inventors: Guenter FORTMEIER, Aloys SCHROEDER, Matthias KOERNER, Eugen SEIBEL
  • Publication number: 20190300529
    Abstract: A process for preparing the compound of formula I comprising: a) coupling a compound of formula 2 wherein a leaving group O—SO2—R is selected from the triflate group, the tosylate group, the mesylate group, the besylate group, the nosylate group or the brosylate group, with a suitable boronic acid, a trifluoroborate or a boronic acid ester under argon condition and in the presence of a catalyst and a base in a suitable solvent and then isolating the product as an acid addition salt to afford the compound of formula Ia and b) converting the acid addition salt of formula Ia wherein the acid HX comprises suitable organic or inorganic acids into the compound of formula I by treatment with at least a stoichiometric equivalent of a suitable base.
    Type: Application
    Filed: March 6, 2019
    Publication date: October 3, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Bjoern BARTELS, Philipp CUENI, Matthias KOERNER, Dieter MURI
  • Publication number: 20190291160
    Abstract: The invention relates to a method for machining a sheet-metal profile 1, wherein the sheet-metal profile 1 is trimmed in a multi-stage cutting process and a cutting edge 2 is produced. Here, pre-cutting is firstly performed on the sheet-metal profile 1, whereby a free space 3 is generated. Stamping of the sheet-metal profile 1 is subsequently performed, wherein the thickness d of the sheet-metal profile 1 along the cutting edge 2 to be produced is reduced. Subsequently, the cutting finishing of the sheet-metal profile 1 is performed, wherein, in particular, cutting is performed in the opposite direction to the stamping of the outline of the finished contour, and the cutting edge 2 is generated.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 26, 2019
    Inventors: Guenter FORTMEIER, Matthias KOERNER
  • Patent number: 10300962
    Abstract: An axle carrier for a motor vehicle is disclosed having at least two attachment points, a metallic upper shell and a lower shell of fiber composite material coupled to the metallic upper shell. A first load path extending through the metallic upper shell between the at least two attachment points in an edge region, and a second load path shorter that the first load path extending through the lower shell.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: May 28, 2019
    Assignee: BENTELER AUTOMOBILTECHNIK GMBH
    Inventors: Alex Mirau, Oliver Seibt, Guenter Fortmeier, Matthias Koerner, Frank Hoecker, Kim-Henning Sauerland
  • Publication number: 20190048002
    Abstract: The invention relates to small molecule imaging tools.
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Publication number: 20190048003
    Abstract: The invention relates to small molecule imaging tools.
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Publication number: 20190023329
    Abstract: The present invention relates to an axle carrier 1 and to a method for the production of the axle carrier 1. The axle carrier 1 has an upper shell 2 from an aluminum die-casting and a lower shell 3 from a fiber composite material. On a ribbed structure of the lower shell 3, an upper end 14 of the reinforcing ribs 9 is preferably configured so as to be widened such that the bearing face between the reinforcing rib 9 and the upper shell 2 is enlarged and, on account thereof, the strength of the axle carrier 1 produced is increased.
    Type: Application
    Filed: January 16, 2018
    Publication date: January 24, 2019
    Inventors: Matthias KOERNER, Thomas HENKSMEIER, Guenter FORTMEIER, Frank HOECKER, Aloys SCHROEDER
  • Patent number: 10138234
    Abstract: The invention relates to compounds of formula I: and to pharmaceutically acceptable acid addition salts thereof, wherein R1-R6, Ra, and Rb have any of the values defined in the specification. The compounds are suitable as imaging tools.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 27, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Publication number: 20180326099
    Abstract: The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, besides others, beta-amyloid aggregates or alpha-synuclein aggregates.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 15, 2018
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Luca GOBBI, Henner KNUST, Matthias KOERNER, Dieter MURI
  • Publication number: 20180281044
    Abstract: The disclosure relates to a method for producing a shaped sheet metal part from a billet by UO forming. First, a preform is created by the U-forming. Then, final forming to give a final form is carried out by the O-forming. The preform has in cross section a maximum width that is smaller than the maximum width of the final form produced after the O-forming.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 4, 2018
    Inventors: Guenter FORTMEIER, Thomas HENKSMEIER, Matthias KOERNER, Aloys SCHROEDER, Eugen SEIBEL
  • Publication number: 20180236881
    Abstract: An axle carrier for an electric motor vehicle and a method of manufacturing thereof is disclosed. The axle carrier has a shell component including an upper shell and a lower shell made from a fiber-composite material, and at least one induction line is integrated in the lower shell.
    Type: Application
    Filed: February 21, 2018
    Publication date: August 23, 2018
    Inventors: Volker GRIENITZ, Hermann OPDEMOM, Matthias KOERNER, Frank RABE
  • Patent number: 10004817
    Abstract: The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, besides others, beta-amyloid aggregates or alpha-synuclein aggregates.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: June 26, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Matthias Koerner, Dieter Muri
  • Patent number: 9957266
    Abstract: The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, for example, beta-amyloid aggregates or alpha-synuclein aggregates.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 1, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Gobbi, Henner Knust, Matthias Koerner, Dieter Muri