Abstract: Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof), or the use of the conjugate in medicine.

Abstract: A method includes capturing a first image of the sample via a detector, wherein the particles of the primary particle beam have a first average energy so that the interaction products detected by the detector predominantly contain sample information from a sample layer lying below the sample surface. The method also includes removing the outermost sample layer with the aid of the cutting device, and capturing a second image of the sample via the detector, wherein the particles of the primary particle beam have a second average energy so that the interaction products detected by the detector predominantly contain sample information from the surface layer of the sample. The method further includes calculating the lateral shift/lateral offset of the sample from a comparison of the first and second images, and compensating for the lateral offset.

Abstract: A method includes capturing a first image of the sample via a detector, wherein the particles of the primary particle beam have a first average energy so that the interaction products detected by the detector predominantly contain sample information from a sample layer lying below the sample surface. The method also includes removing the outermost sample layer with the aid of the cutting device, and capturing a second image of the sample via the detector, wherein the particles of the primary particle beam have a second average energy so that the interaction products detected by the detector predominantly contain sample information from the surface layer of the sample. The method further includes calculating the lateral shift/lateral offset of the sample from a comparison of the first and second images, and compensating for the lateral offset.

Abstract: A charged particle source comprises at least one gas inlet configured to supply gas particles, at least one tip having a tip apex being biased to provide an electrical field for generating charged particles, and at least one ionization area to which gas particles are supplied. The gas particles are ionized in the ionization area due to the electrical field. Additionally, the charged particle source comprises at least one first electrode configured to accelerate charged particles and at least one light emitting device providing a light beam. The light beam is focused to a focus point in the ionization area, specifically, to a focus volume such that the ionization area is at least partly positioned in the focus volume. The ionization area is arranged between the tip apex and the first electrode. The distance between the ionization area and the tip apex may be from 0.1 nm to 1 nm.

Abstract: A particle beam microscope includes an illumination system generating a particle beam having a ring-shaped conical configuration. A selective detection system is configured to selectively detect one of two groups of particles having traversed the object region. The first group of particles includes the particles that traversed the object region un-scattered or scattered by a small scattering amount. The second group of particles includes particles scattered in the object region by a greater scattering amount.

Abstract: An arrangement for holding a particle beam device, in particular an electron beam device, on at least one base structure, includes at least one receiving unit, at least one damping unit which is to be positioned between the base structure and the receiving unit, at least one damping element being arranged at the receiving unit, and at least one holding element being arranged at the damping element.

Abstract: Methods and systems are described for storage and retrieval of complex data. An example method may store a first data item in a first data table included in a database. An aggregated data object may be generated based on preprocessing the first data table based on satisfying a predefined retrieval query. The aggregated data object may be stored based on a preprocessed format in a cluster table included in the database. The first data table may be updated, and the aggregated data object may be updated in the cluster table based on the update of the first data table.

Abstract: A particle beam microscope includes an illumination system generating a particle beam having a ring-shaped conical configuration. A selective detection system is configured to selectively detect one of two groups of particles having traversed the object region. The first group of particles includes the particles that traversed the object region un-scattered or scattered by a small scattering amount. The second group of particles includes particles scattered in the object region by a greater scattering amount.

Abstract: The present invention discloses a self-piercing element, that can be fastened to a structural component by means of piercing and beading. Additionally, the present invention discloses an apparatus for seating the self-piercing element and a corresponding method. The self-piercing element comprises a functional head, a seat geometry and a cutting geometry, while the cutting geometry has a radially outwards arranged, centering exterior bevel, a radially inward arranged interior bevel and a cutting edge arranged in between.

Abstract: Methods and systems are described for storage and retrieval of complex data. An example method may store a first data item in a first data table included in a database. An aggregated data object may be generated based on preprocessing the first data table based on satisfying a predefined retrieval query. The aggregated data object may be stored based on a preprocessed format in a cluster table included in the database. The first data table may be updated, and the aggregated data object may be updated in the cluster table based on the update of the first data table.