Abstract: Machine learning approach can combine mass spectral imaging (MSI) techniques, one with low spatial resolution but intact molecular spectra and the other with nanometer spatial resolution but fragmented molecular signatures, to predict molecular MSI spectra with submicron spatial resolution. The machine learning approach can perform transformations on the spectral image data of the two MSI techniques to reduce dimensionality, and using a correlation technique, find relationships between the transformed spectral image data. The determined relationships can be used to generate MSI spectra of desired resolution.

Abstract: Provided is a method for data transmission between at least one first network and at least one second network, wherein a) for at least one data transmission between the at least one first network and the at least one second network, at least one connection between the first network and the second network is established and a datum or data are directed by means of a resource allocation unit arranged between the networks, and b) for the establishment of the at least one connection, the resource allocation unit exclusively allocates at least one net access resource, e.g. network cards or network adapters, which can be coupled to the second net, and a one-way communication unit arranged upstream of the net access resource for establishing a feedback-free data transmission direction.

Abstract: A method includes: A) establishing a data connection between a first communication partner and a second communication partner by use of a connection key, B) the first communication partner and/or the second communication partner encrypts the connection key for the data connection by use of an additional key, and C) the first communication partner transmits a message, which contains an unencrypted part and a part encrypted by use of the connection key, to the second communication partner. The unencrypted part of the message contains the connection key encrypted by means of the additional key.

Abstract: Provided is a method for data transmission between at least one first network and at least one second network, wherein a) for at least one data transmission between the at least one first network and the at least one second network, at least one connection between the first network and the second network is established and a datum or data are directed by means of a resource allocation unit arranged between the networks, and b) for the establishment of the at least one connection, the resource allocation unit exclusively allocates at least one net access resource, e.g. network cards or network adapters, which can be coupled to the second net, and a one-way communication unit arranged upstream of the net access resource for establishing a feedback-free data transmission direction.

Abstract: A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.

Abstract: Machine learning approach can combine mass spectral imaging (MSI) techniques, one with low spatial resolution but intact molecular spectra and the other with nanometer spatial resolution but fragmented molecular signatures, to predict molecular MSI spectra with submicron spatial resolution. The machine learning approach can perform transformations on the spectral image data of the two MSI techniques to reduce dimensionality, and using a correlation technique, find relationships between the transformed spectral image data. The determined relationships can be used to generate MSI spectra of desired resolution.

Abstract: A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.

Abstract: Gaseous analyte molecules are ionized at atmospheric pressure and provided to an inlet capillary of an ion spectrometer vacuum system by passing the ions through a reaction tube that ends in a conical intermediate piece for a gastight and smooth transition into the inlet capillary. The reaction tube is shaped so that the atmospheric pressure gas stream passing therethrough form the entrance of the tune to the intermediate piece is stably laminar. Analyte molecules from gas chromatographs, spray devices or vaporization devices can be introduced into the entrance of the reaction tube and ionized within the tube by single- or multi-photon ionization, by chemical ionization, by reactant ions or by physical ionization. For single- or multi-photon ionization, a beam from a laser can be passed axially down the reaction tube. Reactant ions can be produced by any means outside of the reaction tube and mixed with the analyte molecules within the tube.

Abstract: Position transmitting equipment for ascertaining the position of a rail-guided elevator car includes a code carrier, which is arranged over the car travel path in fixed location on a guide rail with code marks of different permeability. A permanently precise reading of the coding is ensured by the fact that the code carrier is fixedly connected with a non-magnetic cover externally covering the code marks. The code carrier together with the outwardly facing non-magnetic cover are inserted into a receiving groove of the car guide rail, whereby a simple and reliable mounting is achieved and, in addition, temperature-dependent differences in expansion between the code carrier and the guide rail are avoided.

Abstract: Equipment for determining a position of an elevator car movable along a guide flange of a guide rail in an elevator installation with a code carrier extending in a travel direction along a length of the guide rail in a groove includes a mount attached to the elevator car, a code reading sensor system attached to the mount, and a plurality of guide rollers rotatably attached to the mount and rolling on the guide flange to maintain the code reading sensor system at a predetermined spacing from the code carrier along two axes.

Abstract: Equipment for determining a position of an elevator car movable along a guide flange of a guide rail in an elevator installation with a code carrier extending in a travel direction along a length of the guide rail in a groove includes a mount attached to the elevator car, a code reading sensor system attached to the mount, and a plurality of guide rollers rotatably attached to the mount and rolling on the guide flange to maintain the code reading sensor system at a predetermined spacing from the code carrier along two axes.

Abstract: Position transmitting equipment for ascertaining the position of a rail-guided elevator car includes a code carrier, which is arranged over the car travel path in fixed location on a guide rail with code marks of different permeability. A permanently precise reading of the coding is ensured by the fact that the code carrier is fixedly connected with a non-magnetic cover externally covering the code marks. The code carrier together with the outwardly facing non-magnetic cover are inserted into a receiving groove of the car guide rail, whereby a simple and reliable mounting is achieved and, in addition, temperature-dependent differences in expansion between the code carrier and the guide rail are avoided.

Abstract: The present invention provides methods and compositions for the construction of custom cDNA microarrays. In particular, the methods involve the selection of relevant clusters based on knowledge and expression patterns using public database information and the identification of the best representative cDNA clones within the selected cluster. The methods facilitate the construction of custom microarrays suitable for use in any biotechnological art. In preferred embodiments, the present invention provides the the ImmunoChip.