Patents by Inventor Matthias Luc Aime Versele

Matthias Luc Aime Versele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocylic pyrimidine derivatives
    Patent number: 10017509
    Abstract: The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: July 10, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gaston Stanislas Marcella Diels, Bruno Schoentjes, Matthias Luc Aime Versele, Didier Jean-Claude Berthelot, Marc Willems, Marcel Viellevoye, Werner Constant Johan Embrechts, Berthold Wroblowski, Lieven Meerpoel
  • N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors
    Patent number: 9688662
    Abstract: The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: June 27, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ian Stansfield, Yannick Aime Eddy Ligny, Nathalie Claudie Isabelle Amblard, Matthias Luc Aime Versele
  • MACROCYLIC PYRIDINE DERIVATIVES
    Publication number: 20170022201
    Abstract: The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Application
    Filed: April 2, 2015
    Publication date: January 26, 2017
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Gaston Stanislas Marcella Diels, Bruno Schoentjes, Matthias Luc Aime Versele, Didier Jean-Claude Berthelot, Mar Willems, Marcel Viellevoye, Francois Maria Sommen, Berthold Wroblowski, Lieven Meerpoel
  • NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-b]PYRIDIN-5-YL)-4-QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4-QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS
    Publication number: 20160039798
    Abstract: The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 11, 2016
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Ian Stansfield, Yannick Aime Eddy Ligny, Nathalie Claudie Isabelle Amblard, Matthias Luc Aime Versele
  • METHOD FOR PROFILING KINASE INHIBITORS
    Publication number: 20100234238
    Abstract: The present invention is concerned with method for pharmacologically profiling compounds using an array of substrates, in particular kinase substrates, immobilized on a porous matrix. This method was found particular useful in the prediction of drug response, i.e. to enable the distinction between responders and non-responders in the treatment of cells, tissues, organs or warm-blooded animals with the compound to be tested, and in compound differentiation.
    Type: Application
    Filed: October 29, 2007
    Publication date: September 16, 2010
    Applicant: Janssen Pharmaceutica N V
    Inventors: Matthias Luc Aimé Versele, Timothy Pietro Suren Perera, Willem Jan-Paul Edmond Talloen