Abstract: The present invention relates to chemical compounds which can be used in particular as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting Ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of these compounds as pharmaceutical agents and the use of the pharmaceutical agents for the treatment of tumor diseases.

Abstract: A reactor for producing synthesis gas by partial oxidation of a carbon-containing fuel, having a reaction space and a cooling space, wherein a cooled gas guide tube connects the reaction space and the cooling space to one another. The gas guide tube has a gas inlet region, which adjoins the reaction space, and a gas outlet region, which adjoins the cooling space. The gas guide tube has an inner tube and an outer tube, as a result of which an annular gap is formed, wherein the annular gap is connected fluidically to a coolant feed, and the inner tube has an opening to the annular gap in the gas inlet region of the gas guide tube, and a baffle is arranged in the region of this opening, and an orifice is arranged in the gas outlet region of the gas guide tube.

Abstract: An electric vehicle with at least one brake system and an axle and a method to operate the electric vehicle. The at least one brake system is arranged at the axle and includes a wet service brake, a parking brake, and an actuator. The actuator is adjustable and can communicate with a service brake in a service brake region or with the parking brake in a securing region to generate a braking action at the axle in each instance. A neutral region in which the actuator communicates neither with the service brake nor with the parking brake is located between the service brake region and the securing region. A plurality of brake systems are advantageously used jointly in the various configurations.

Abstract: In various examples, a technique for performing a particle-based simulation includes propagating, via a first portion of a machine learning model, a first plurality of features associated with a plurality of particles across a hierarchy of grids, wherein the hierarchy of grids includes a first grid having a first grid spacing and a second grid having a second grid spacing that is greater than the first grid spacing. The technique also includes propagating, via a second portion of the machine learning model, a second plurality of features across the hierarchy of grids to the plurality of particles. The technique further includes determining a plurality of accelerations associated with the plurality of particles based on the second set of features propagated to the plurality of particles, and generating a simulation associated with the plurality of particles based on the plurality of accelerations.

Abstract: A method for localizing a sound source for a binaural hearing system with first and second hearing instruments. First and second input signals are formed from an ambient sound signal and directional signals are formed by directional signal processing of the input signals. The directional signals have a minimum sensitivity in different minimum directions with respect to a preferred direction of the binaural hearing system. Based on the directional signals, first and second source directions of the sound source are determined starting from the first and second hearing instrument, respectively. Based on the source directions and a distance between the first and second hearing instruments, the distance of said sound source from a reference point of the binaural hearing system and a main direction of the said sound source are determined to thereby localize the sound source.

Abstract: A brake disc (1) including at least one friction ring (2) and a brake hub (3) connected to the friction ring (2) for conjoint rotation. A side wall section (17) of the brake hub (3) has a plurality of radially oriented deformations (5). A contact surface (7) extending in the radial direction is formed by these deformations (5), and a rotationally fixed connection (8) is established by the contact surface (7) between the friction ring (2) and the brake hub (3). A ratio Da/Di formed from the outer diameter Da of a side wall section (17) of the brake hub (3) and an inner diameter Di of the friction ring (2) is at most 1.01.

Abstract: A drug delivery device (1) having a delivery unit (3) including a drug container (6), a liquid flow system (7), a pumping system (8), and a casing (9) enclosing therein the drug container, the pumping system and at least a part of the liquid flow system is disclosed. The drug container has a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion. The drug container is contained within a container receiving cavity (75) of a container casing portion (38) and the container receiving cavity is fluidically interconnected to a fluid outlet (31) of the pumping system (8) in a gas tight manner. The pumping system pumps environmental air into the container receiving cavity (75) thus applying pressure on a back end (73) of the plunger for delivery of a liquid drug.

Abstract: A method operates a hearing instrument having an acousto-electric first input transducer and an electro-acoustic output transducer. A first input signal is generated by the first input transducer from an ambient sound. The first input signal and/or a first intermediate signal derived from the first input signal is resolved into a multiplicity of frequency bands. An output signal is generated from the first input signal, or from the first intermediate signal, by frequency-selective signal processing. A relevant subset of frequency bands is determined from the aforementioned multiplicity such that, in each frequency band of the relevant subset, an output sound generated from the output signal by the output transducer makes a contribution that lies above a predefined or desired threshold, further, with the aid of signal components of the first input signal, or of the first intermediate signal.

Abstract: A pump (1) comprising a stator (4) and a rotor (6) axially and rotatably movable relative to the stator, the stator (4) comprising a piston chamber (10) comprising a radial surface (30), an inlet (3) comprising an inlet mouth (28) formed in the radial surface and an outlet (5) comprising an outlet mouth (29) formed in the radial surface, the rotor (6) comprising a piston portion (13) comprising a radial surface (16), an end face (15) and a non-axisymmetric indent (14) formed between the radial surface (16) and the end face (15) of the piston portion (13), wherein the indent (14) is arranged to overlap at least partially the inlet mouth (28) over a range of angular positions of the rotor relative to the stator corresponding to a pump intake phase, and arranged to overlap at least partially the outlet mouth (29) over a range of angular positions of the rotor relative to the stator corresponding to a pump expel phase, and wherein the radial surface (16) of the piston portion (13) is configured to close the outle

Abstract: A method trains a speaker recognition unit of a hearing aid of a user, wherein the hearing aid is connected to a communication device of the user, for carrying out a remote conversation between the user of the hearing aid and a conversation partner of the user. An audio signal of the conversation partner is received by the communication device for output to the user. A speaker ID is assigned to the conversation partner, wherein a number of speech samples of the conversation partner is extracted from the audio signal. The speech samples are assigned to the speaker ID and form a training data set jointly therewith. The speaker recognition unit of the hearing aid is trained using the training data set in order to recognize the conversation partner in future.

Abstract: A drug delivery device (1), comprising a delivery unit (3) including a drug container (6), a liquid flow system (7), a pressurized gas source, and a casing (9) enclosing therein the drug container, the pressurized gas source and at least a part of the liquid flow system, the drug container comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion, the drug container being contained within a container receiving cavity (75) of a container casing portion (38) of the casing (9) and the container receiving cavity is fluidically interconnected to a fluid outlet (31) of the pressurized gas source in a gas tight manner, the pressurized gas source configured to supply pressurized gas in the container receiving cavity (75) thus applying pressure on a back end (73) of the plunger for delivery of the liquid drug.

Abstract: An actuator for aviation applications, in particular for adjusting rotor blades in a helicopter, may include an electromechanical drive assembly connected to an output drive via a downstream transmission, where the drive assembly is divided into sub-drives that can be operated independently, and where at least two sub-drives are spatially separated from one another in that the transmission is placed between these sub-drives. The transmission may include at least two harmonic gearings coupled to one another by at least one first coupling element, where a first harmonic gearing is located inside a non-rotating first housing, where a second harmonic gearing is located inside a rotating second housing, and where the second housing is connected to the output drive.

Abstract: A holding and moving device includes a support foot, a bearing arm secured pivotably onto the support foot to form a useful load side section and a weight-side section, a first pivot arm connected to the useful load side section of the bearing arm for attachment of a useful load and/or holding device for a useful load, and a second pivot arm connected to the weight-side section of the bearing arm for attachment of a balance weight. The bearing arm and the first and second pivot arms are connected to one another such that the alignment of the first and second pivot arms are essentially parallel to one another in each position. The second pivot arm and/or the weight-side section are designed such that the weight of the first pivot arm and/or of the useful load side section is balanced in each position of the holding and moving device.

Abstract: A drug delivery device (1), comprising a delivery unit (3) including a drug container (6) comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion, and a drive unit (4) comprising a pneumatic flow system (74) and a pneumatic pumping system configured to pump air via the pneumatic flow system (74) to a space behind the plunger to generate a gas pressure to advance the plunger in the container during drug delivery. The drug delivery device comprises a sealing adaptor (9) mounted on an end of the drug container facing an outer side of the plunger, the sealing adaptor (9) comprising a sealing plug (23) inserted inside an end of the barrel portion, the sealing plug (23) comprising an orifice (26) configured for pluggable sealing connection to a gas channel connector (40) of the pneumatic flow system.

Abstract: Push actuated double fluid dispenser (1), comprising a container (2) having a first cavity (4a) and a second cavity (4b) separated from the cap first cavity (4a), and a dispensing pump device (6) in a general form of a cap assembled to the container over the first and second cavities, the dispensing pump device comprising a base part (7) and a cap part (8) including a pump mechanism (16) comprising an elastic flexible pump membrane (18) manually movable from an uncompressed state to a compressed state.

Abstract: A metering console (100) includes a housing (110) adapted to allow flow of a liquid (F) therethrough. The housing (110) is adapted to attach with one or more gardening devices (132, 152). The metering console (100) includes a display (170) associated with the housing (110). The metering console (100) is characterized in that the display (170) is rotatably engaged with the housing (110) of the metering console (100) such that the display (170) rotates along a central axis (A-A?) of the housing (110).

Abstract: A drug delivery device (1), comprising a delivery unit (3) including a drug container (6), a liquid flow system (7), a pumping system (8), and a casing (9) enclosing therein the drug container, the pumping system and at least a part of the liquid flow system, the drug container comprising a barrel portion (6a) and a plunger (12) slidably mounted within the barrel portion and sealing the drug (78) within the container at one end of the barrel portion, the liquid flow system (7) connected fluidically to the drug container during delivery of the liquid drug.

Abstract: The invention relates to a method for automatically examining a liquid sample, which has a liquid and at least one particle, by means of a first measurement signal which emanates from a liquid region and which serves to determine at least one particle with a first property, and by means of a second measurement signal which emanates from the liquid region and serves to determine at least one particle with a second property, the first measurement signal and the second measurement signal being evaluated independently of one another and whether a particle condition has been satisfied in the liquid region subsequently being determined on the basis of the evaluated first measurement signal and the evaluated second measurement signal.

Abstract: A method operates a hearing aid, in particular a classic hearing aid. The hearing aid includes an input transducer, a signal processing device, and an output transducer. Wherein an occurrence of a comb filter effect is determined by the signal processing device, and wherein a countermeasure is controlled by the signal processing device as a function of the determined occurrence of the comb filter effect.

Abstract: A metering console (100) includes a housing (110) adapted to allow flow of a liquid (F) therethrough. The housing (110) is adapted to attach with one or more gardening devices (132, 152). The metering console (100) includes a display (170) associated with the housing (110). The metering console (100) is characterized in that the display (170) is rotatably engaged with the housing (110) of the metering console (100) such that the display (170) rotates along a central axis (A-A?) of the housing (110).