Abstract: Compositions comprising a macrophage-targeted carrier and one or more therapeutic agents that modulate cardiac conductance, and methods of using the same for treating subjects with cardiac rhythm disorders, e.g., bradycardia or tachycardia.

Abstract: An animal, specimen, or imaging phantom is imaged in precise increments over at least 360 degrees. The animal, specimen, or imaging phantom is supported within a subject holder. The subject holder has an elongated portion or tube for holding securely the animal, specimen or imaging phantom. The subject holder is connected to an actuator motor driver. The actuator motor driver causes the subject holder to rotate at the precise increments, and an image of the animal, specimen, or imaging phantom is captured at each increment. The subject holder limits movement of the subject being imaged at each increment.

Abstract: Compositions comprising a macrophage-targeted carrier and one or more therapeutic agents that modulate cardiac conductance, and methods of using the same for treating subjects with cardiac rhythm disorders, e.g., bradycardia or tachycardia.

Abstract: This disclosure relates to specific nanometer-sized nanoparticles made from unmodified dextran (DNPs), DNP conjugates, and related compositions and methods of use.

Abstract: Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.

Abstract: An animal, specimen, or imaging phantom is imaged in precise increments over at least 360 degrees. The animal, specimen, or imaging phantom is supported within a subject holder. The subject holder has an elongated portion or tube for holding securely the animal, specimen or imaging phantom. The subject holder is connected to an actuator motor driver. The actuator motor driver causes the subject holder to rotate at the precise increments, and an image of the animal, specimen, or imaging phantom is captured at each increment. The subject holder limits movement of the subject being imaged at each increment.

Abstract: Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.

Abstract: The present invention provides compositions and methods for the treatment of atherosclerosis and other related diseases. In some embodiments, a method comprises providing a composition and forming a coating of the composition on at least a portion of the interior and/or exterior surface of a tissue lumen or other body surface. The composition may remain associated with the tissue lumen or other body surface even in the presence of a strong flow of a fluid (e.g., blood flow in a blood vessel). The composition may associate with the tissue lumen via a plurality of covalent bonds. In some cases, the compositions may comprise at least one additive, for example, a therapeutically active agent or an imaging agent.

Abstract: The present invention relates to an electrode catheter for defibrillation, mapping or ablation of cardiac tissue. Said catheter comprises a terminal (40) on the proximal end of the electrode catheter and one or more sensing and/or treatment electrodes (14, 16) that are situated on or in the vicinity of the distal end of the electrode catheter, in addition to at least one electric conductor (44, 62), which is used to electrically connect a respective sensing or treatment electrode to the terminal. The electric conductor (44, 62) is composed of carbon and the electrode catheter is configured to be suitable for us as part of magnetic resonance tomography and for connection to electrophysiotherapy equipment. Said catheter comprises at least one defibrillation electrode, or at least one sensing electrode (14, 16) for the recording and evaluation of cardiac tissue potentials, or at least one treatment electrode (14) for delivering high-frequency currents for ablation purposes.

Abstract: The present invention relates to an electrode catheter for defibrillation, mapping or ablation of cardiac tissue. Said catheter comprises a terminal (40) on the proximal end of the electrode catheter and one or more sensing and/or treatment electrodes (14, 16) that are situated on or in the vicinity of the distal end of the electrode catheter, in addition to at least one electric conductor (44, 62), which is used to electrically connect a respective sensing or treatment electrode to the terminal. The electric conductor (44, 62) is composed of carbon and the electrode catheter is configured to be suitable for us as part of magnetic resonance tomography and for connection to electrophysiotherapy equipment. Said catheter comprises at least one defibrillation electrode, or at least one sensing electrode (14, 16) for the recording and evaluation of cardiac tissue potentials, or at least one treatment electrode (14) for delivering high-frequency currents for ablation purposes.