Patents by Inventor Matthias Ocker

Matthias Ocker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting expression of anti-apoptotic genes
    Patent number: 7473525
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising a complementary RNA strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially identical to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: January 6, 2009
    Assignee: Alnylam Europe AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Philipp Hadwiger, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan
  • New pharmaceutical combination
    Publication number: 20050054647
    Abstract: Pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at lest one compound of general formula II) or Iia), or pharmaceutical combinations comprising at least one compound of general formula I-A or I-AA, and at least one compound of general formula II) or Iia), and an anti-hormone, and their use for the treatment of different diseases resulting by persistent angiogenesis are described.
    Type: Application
    Filed: December 29, 2003
    Publication date: March 10, 2005
    Inventors: Detlev Schuppan, Marion Ganslmayer, Christoph Herold, Matthias Ocker, Karl-Heinz Thierauch
  • Compositions and methods for treating pancreatic cancer
    Publication number: 20040121348
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a K-ras oncogene, comprising a complementary RNA strand which is substantially identical to at least a part of a K-ras gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a K-ras oncogene using the pharmaceutical composition; and methods for inhibiting the expression of a K-ras oncogene in a cell.
    Type: Application
    Filed: March 7, 2003
    Publication date: June 24, 2004
    Applicant: Ribopharma AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan
  • Compositions and methods for inhibiting expression of anti-apoptotic genes
    Publication number: 20040001811
    Abstract: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising a complementary RNA strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially identical to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
    Type: Application
    Filed: March 7, 2003
    Publication date: January 1, 2004
    Applicant: Ribopharma AG
    Inventors: Roland Kreutzer, Stefan Limmer, Hans-Peter Vornlocher, Philipp Hadwiger, Anke Geick, Matthias Ocker, Christoph Herold, Detlef Schuppan