Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: A request to calculate workload for a number of time buckets is received. In response to the request, one or more sets of activities with equal execution timeframe are determined. In one aspect, for the one or more sets of activities, net execution duration of activities from the one or more sets of activities is aggregated to determine workloads of the one or more sets of activities. Planned work time consumption of the determined workloads is calculated. In one aspect, calculated planned work time consumption of the workloads is distributed across the number of time buckets. Distributed planned work time consumption of the workloads is aggregated, by the time buckets to calculate the workload for the time buckets.

Abstract: The invention relates to methods for investigating mixtures of substances by capillary electrophoretic separation, in particular of biopolymers such as proteins, proteoglycanes or other protein conjugates, or their digestion peptides. The invention comprises the analysis of specific, well-separated substances of analytical interest found in complex mixtures by subjecting the mixture of substances together to a selective derivatization process using charge-carrying groups prior to the electrophoretic separation, so that the substances of interest can be detected, essentially alone, within a specified time window.

Abstract: The invention relates to methods used for mass spectrometric analysis of substances separated by capillary electrophoresis, in particular biopolymers such as proteins, proteoglycanes or other protein conjugates or their digest peptides. The invention consists in reducing the electrophoresis voltage upon appearance of the first analytically interesting substance, thereby maintaining the high separation power and gaining sensitivity. With direct coupling, e.g. by electrospray, the electrophoretic voltage may be directly controlled by the ion current measured by the mass spectrometer.