Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The invention relates to methods for investigating mixtures of substances by capillary electrophoretic separation, in particular of biopolymers such as proteins, proteoglycanes or other protein conjugates, or their digestion peptides. The invention comprises the analysis of specific, well-separated substances of analytical interest found in complex mixtures by subjecting the mixture of substances together to a selective derivatization process using charge-carrying groups prior to the electrophoretic separation, so that the substances of interest can be detected, essentially alone, within a specified time window.

Abstract: The invention relates to methods used for mass spectrometric analysis of substances separated by capillary electrophoresis, in particular biopolymers such as proteins, proteoglycanes or other protein conjugates or their digest peptides. The invention consists in reducing the electrophoresis voltage upon appearance of the first analytically interesting substance, thereby maintaining the high separation power and gaining sensitivity. With direct coupling, e.g. by electrospray, the electrophoretic voltage may be directly controlled by the ion current measured by the mass spectrometer.