Patents by Inventor Matthias Plitzko
Matthias Plitzko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230348967Abstract: The present disclosure relates to a method, including providing one or more lyophilised microspheres in a mixing vessel at a first temperature and generating a fluidized bed of the one or more lyophilised microspheres in the mixing vessel, under conditions effective to encapsulate the one or more lyophilised microspheres with a coating formulation. In an example, the fluidized bed has a fluidization rate of between about 1 cubic meters per hour (m3/h) and about 30 m3/h. In another example, the fluidized bed has an environmental humidity of between about 10% and about 20%. In still another example, the coating formulation is applied at a spray rate of between about 1.5 grams per minute (g/min) and about 10 g/min. In yet another example, the coating formulation is applied at an atomizing rate of between about 0.5 bar and about 1.5 bar. In a further example, the fluidized bed is in a Wurster configuration, a top spray configuration, or a combination thereof.Type: ApplicationFiled: April 26, 2023Publication date: November 2, 2023Inventors: Sébastien RICOULT, Matthias PLITZKO, Bernhard LUY
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Patent number: 11578917Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.Type: GrantFiled: November 27, 2019Date of Patent: February 14, 2023Assignee: Sanofi Pasteur SAInventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
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Patent number: 11512898Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202), The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.Type: GrantFiled: October 16, 2019Date of Patent: November 29, 2022Assignee: Sanofi Pasteur SAInventors: Thomas Gebhard, Roland Kaiser, Matthias Plitzko, Manfred Struschka, Bernhard Luy
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Patent number: 11499777Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chambType: GrantFiled: January 8, 2020Date of Patent: November 15, 2022Assignee: Sanofi Pasteur SAInventors: Thomas Gebhard, Roland Kaiser, Bernhard Luy, Matthias Plitzko, Manfred Struschka, Christian Zerillo
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Publication number: 20210290534Abstract: A method for the production of freeze-dried pellets comprising an anti-FXIa antibody comprises the steps of: a) freezing droplets of a solution comprising an anti-FXIa antibody to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising an anti-FXIa antibody into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.Type: ApplicationFiled: July 5, 2019Publication date: September 23, 2021Applicant: Bayer AktiengesellschaftInventors: Stefan Christian SCHNEID, Stefan HEKE, Matthias PLITZKO
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Publication number: 20210292434Abstract: The present invention refers to novel liquid pharmaceutical high-concentration formulations particularly suitable for subcutaneous administration comprising human antibodies against coagulation factor FXIa as active ingredient, especially those described in WO2013167669, which are stable as liquid formulations over a long period. The invention also refers to lyophilizates of the specified liquid formulation with reduced reconstitution time and also to the use of these formulations in the therapy and prophylaxis of thrombotic or thromboembolic disorder.Type: ApplicationFiled: July 5, 2019Publication date: September 23, 2021Applicant: Bayer AktiengesellschaftInventors: Niklas GOMBERT, Marieke VEURINK, Alexander KLAK, Stefan Christian SCHNEID, Stefan HEKE, Matthias PLITZKO
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Publication number: 20200141647Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chambType: ApplicationFiled: January 8, 2020Publication date: May 7, 2020Applicant: Sanofi Pasteur SAInventors: Thomas GEBHARD, Roland KAISER, Bernhard LUY, Matthias PLITZKO, Manfred STRUSCHKA, Christian ZERILLO
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Publication number: 20200116428Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202), The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.Type: ApplicationFiled: October 16, 2019Publication date: April 16, 2020Applicant: Sanofi Pasteur SAInventors: Thomas GEBHARD, Roland KAISER, Matthias PLITZKO, Manfred STRUSCHKA, Bernhard LUY
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Publication number: 20200109896Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.Type: ApplicationFiled: November 27, 2019Publication date: April 9, 2020Applicant: Sanofi Pasteur SAInventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
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Patent number: 10533800Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chambType: GrantFiled: July 20, 2015Date of Patent: January 14, 2020Assignee: Sanofi Pasteur SAInventors: Thomas Gebhard, Roland Kaiser, Bernhard Luy, Matthias Plitzko, Manfred Struschka, Christian Zerillo
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Patent number: 10527350Abstract: A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles. The drum (104, 302) is in open communication with the vacuum chamber (102) and at least one transfer section (106, 108) is provided for a product transfer between a separate device of the process line and the freeze-dryer (100), the freeze-dryer (100) and the transfer section (106, 108) being separately adapted for closed operation, wherein the transfer section (106, 108) comprises a temperature-controllable inner wall surface.Type: GrantFiled: October 4, 2012Date of Patent: January 7, 2020Assignee: Sanofi Pasteur SAInventors: Matthias Plitzko, Manfred Struschka, Thomas Gebhard, Bernhard Luy
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Patent number: 10451345Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.Type: GrantFiled: October 4, 2012Date of Patent: October 22, 2019Assignee: Sanofi Pasteur SAInventors: Thomas Gebhard, Roland Kaiser, Matthias Plitzko, Manfred Struschka, Bernhard Luy
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Patent number: 10407489Abstract: A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.Type: GrantFiled: November 4, 2016Date of Patent: September 10, 2019Assignee: Bayer Pharma AktiengesellschaftInventors: Carsten Olbrich, Matthias Plitzko, Bernhard Luy, Stefan Christian Schneid
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Publication number: 20180327478Abstract: A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.Type: ApplicationFiled: November 4, 2016Publication date: November 15, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Carsten OLBRICH, Matthias PLITZKO, Bernhard LUY, Stefan Christian SCHNEID
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Patent number: 10006706Abstract: A process line (300) for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer (304) for freeze drying the particles, wherein a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304), for the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for closed operation, and the spray chamber (302) is adapted for separation of the liquid droplets from any cooling circuit.Type: GrantFiled: October 4, 2012Date of Patent: June 26, 2018Assignee: Sanofi Pasteur SAInventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
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Patent number: 9920989Abstract: A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.Type: GrantFiled: October 4, 2012Date of Patent: March 20, 2018Assignee: Sanofi Pasteur SAInventors: Bernhard Luy, Matthias Plitzko, Manfred Struschka
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Publication number: 20170219283Abstract: The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chambType: ApplicationFiled: July 20, 2015Publication date: August 3, 2017Inventors: Thomas GEBHARD, Roland KAISER, Bernhard LUY, Matthias PLITZKO, Manfred STRUSCHKA, Christian ZERILLO
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Patent number: 9347707Abstract: A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.Type: GrantFiled: October 4, 2012Date of Patent: May 24, 2016Assignee: Sanofi Pasteur SAInventors: Manfred Struschka, Matthias Plitzko, Thomas Gebhard, Bernhard Luy
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Publication number: 20150007445Abstract: A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.Type: ApplicationFiled: October 4, 2012Publication date: January 8, 2015Inventors: Thomas Gebhard, Roland Kasier, Matthias Plitzko, Manfred Struschka, Bernhard Luy
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Publication number: 20140373383Abstract: A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.Type: ApplicationFiled: October 4, 2012Publication date: December 25, 2014Applicant: SANOFI PASTEUR SAInventors: Manfred Struschka, Matthias Plitzko, Thomas Gebhard, Bernhard Luy