Patents by Inventor Matthias Rueth

Matthias Rueth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of inhibiting BTK and SYK protein kinases
    Publication number: 20070219195
    Abstract: Methods of inhibiting a tyrosine kinase wherein said tyrosine kinase is BTK or SYK comprising administering to a patient in need thereof a therapeutically effective amount of a compound according to formula I are disclosed. The compounds are useful for treating auto-immune and inflammatory diseases.
    Type: Application
    Filed: March 20, 2007
    Publication date: September 20, 2007
    Inventors: David Goldstein, Matthias Rueth
  • Arylazole derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7259262
    Abstract: There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Oxazoles, their manufacture and use as pharmaceutical agents
    Patent number: 7247649
    Abstract: The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: July 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Pentafluorosulfanyl compounds
    Patent number: 7235574
    Abstract: The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: June 26, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Guy Georges, Matthias Rueth, Edgar Voss
  • Phthalazinone derivatives
    Patent number: 7226923
    Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: June 5, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Guy Georges, Bernhard Goller, Sabine Huensch, Petra Rueger, Matthias Rueth, Stefan Scheiblich, Christine Schuell, Wolfgang von der Saal, Justin Warne, Stefan Weigand
  • Oxazole derivatives
    Patent number: 7205325
    Abstract: The present invention 1 includes compounds of formula (I), and their pharmaceutically acceptable salts. These compounds are useful in the control or prevention of cancer.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: April 17, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Bernhard Goller, Matthias Rueth, Edgar Voss
  • Aniline derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7205326
    Abstract: Compounds of formula (I) are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: April 17, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Diazine derivatives
    Patent number: 7179812
    Abstract: The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: February 20, 2007
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Wolfgang Jenni, Matthias Rueth, Edgar Voss
  • Pentacyclic kinase inhibitors
    Publication number: 20070037791
    Abstract: The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.
    Type: Application
    Filed: August 14, 2006
    Publication date: February 15, 2007
    Inventors: Thomas Rawson, Brian Safina, Jennafer Dotson, Aihe Zhou, Ignacio Aliagas-Martin, Jason Halladay, Jun Liang, Matthias Rueth, Bing-Yan Zhu
  • Aminopyrazole derivatives
    Publication number: 20060235065
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 17, 2006
    Publication date: October 19, 2006
    Inventors: Guy Georges, Bernhard Goller, Klaus-Peter Kuenkele, Aude Lemarchand, Anja Limberg, Ulrike Reiff, Petra Rueger, Matthias Rueth
  • Tricyclic azole derivatives
    Publication number: 20060235013
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 17, 2006
    Publication date: October 19, 2006
    Inventors: Guy Georges, Bernhard Goller, Hans-Willi Krell, Anja Limberg, Ulrike Reiff, Petra Rueger, Matthias Rueth
  • Tricyclic heterocycles
    Publication number: 20060142247
    Abstract: The present invention relates to the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Inventors: Guy Georges, Bernhard Goller, Klaus-Peter Kuenkele, Anja Limberg, Ulrike Reiff, Petra Rueger, Matthias Rueth, Christine Schuell
  • Phthalazinone derivatives
    Publication number: 20060089359
    Abstract: Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 27, 2006
    Inventors: Edward Boyd, Frederick Brookfield, Guy Georges, Bernhard Goller, Sabine Huensch, Petra Rueger, Matthias Rueth, Stefan Scheiblich, Christine Schuell, Wolfgang von der Saal, Justin Warne, Stefan Weigand
  • Tricycles, their manufacture and use as pharmaceutical agents
    Publication number: 20060069145
    Abstract: The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 23, 2005
    Publication date: March 30, 2006
    Inventors: Georges Guy, Bernhard Goller, Hans-Willi Krell, Klaus-Peter Kuenkele, Anja Limberg, Petra Rueger, Matthias Rueth
  • Indole derivatives
    Publication number: 20060063812
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: September 20, 2005
    Publication date: March 23, 2006
    Inventors: Thomas Friess, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Novel diazine derivatives
    Publication number: 20050222228
    Abstract: The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 31, 2005
    Publication date: October 6, 2005
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Wolfgang Jenni, Matthias Rueth, Edgar Voss
  • Novel oxidized thioether derivatives
    Publication number: 20050203064
    Abstract: The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 4, 2005
    Publication date: September 15, 2005
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Thomas Friess, Lothar Kling, Matthias Rueth, Edgar Voss
  • Novel pentafluorosulfanyl compounds
    Publication number: 20050197370
    Abstract: The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: March 4, 2005
    Publication date: September 8, 2005
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Guy Georges, Matthias Rueth, Edgar Voss
  • Novel arylazole derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20050124670
    Abstract: There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 9, 2005
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss
  • Novel oxazoles, their manufacture and use as pharmaceutical agents
    Publication number: 20050038091
    Abstract: The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: August 3, 2004
    Publication date: February 17, 2005
    Inventors: Birgit Bossenmaier, Walter-Gunar Friebe, Ulrike Reiff, Matthias Rueth, Edgar Voss