Abstract: The present invention relates to a method for diagnosis of Inflammatory Bowel Disease (IBD) based on the determination of expression profiles of miRNAs representative for diagnosis of IBD compared to a reference. In addition, the present invention relates to a kit for diagnosis of IBD comprising means for determining expression profiles of miRNAs representative for IBD.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: The present invention relates to a method for diagnosis of Inflammatory Bowel Disease (IBD) based on the determination of expression profiles of miRNAs representative for diagnosis of IBD compared to a reference. In addition, the present invention relates to a kit for diagnosis of IBD comprising means for determining expression profiles of miRNAs representative for IBD.

Abstract: The invention relates to methods of determining whether a patient responds to a therapeutic treatment of an autoimmune disease, of monitoring the course of an autoimmune disease in a patient, of determining the risk for a relapse of an autoimmune disease in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of an autoimmune disease in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The invention also relates to a method of identifying a compound suitable for the treatment of an autoimmune disease in a patient.

Abstract: The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient.

Abstract: The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

Abstract: The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.

Abstract: Methods and devices provide integrated synthesis of a support for analyte determination and the analyte determination. Preferred embodiments involve particles immobilized on the surface of a support to which receptors are coupled location-specifically, time-specifically or both on pre-determined positions on the support.

Abstract: A method for preparing receptor-coated particles is described which comprises the following steps: a) providing a support body, b) conducting a liquid containing particles into or onto the support body, c) immobilizing the particles on at least one surface area of the support body, d) conducting a liquid which contains receptors or receptor building blocks for synthesizing polymeric receptors over the immobilized particles, e) coupling the receptors or receptor building blocks location—or/and time-specifically to the immobilized particles at in each case predetermined positions of the support body, f) repeating, where appropriate, the steps (d) and (e), until the desired receptors have been synthesized on the immobilized particles at the in each case predetermined positions of the support body.

Abstract: The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups.

Abstract: The invention relates to a method which can be used to test firstly a reaction and secondly the distribution of functional groups on a surface. This method is employed in a situation that demands documentation or testing of a distribution of surface functionalization, which is as homogeneous as possible.

Abstract: The present invention relates to a method for validating the synthesis of arrays, in particular of biopolymers, by step-by-step construction from protected and labeled synthesis building blocks.

Abstract: The present invention relates to a process for synthesizing biopolymers by stepwise assembly from protected synthesis building blocks which carry two-stage protective groups. The two-stage protective groups are activated by a first illumination step and eliminated by a subsequent chemical treatment step. Photoactivatable components which considerably speed up the activation process via intramolecular triplet sensitizers or/and have fluorescence properties are used. The two-stage protective groups can be used in particular within the framework of quality control.

Abstract: The invention relates to a method for the synthesis of biopolymers by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step.

Abstract: A method for preparing receptor-coated particles is described which comprises the following steps:

Abstract: The invention relates to novel amidite derivatives and their use as linker units for synthesizing polymers, especially biopolymers such as nucleic acids, peptides and saccharides, on the surface of solid supports. Use of the linker derivatives of the invention makes it possible to regenerate the surfaces without damage.

Abstract: The invention relates to a novel method for synthesising polymers, particularly biopolymers such as nuclear acids, peptides and saccharides, on the surface of solid supports. The inventive method enables improved quality polymers to be produced at a lower cost. Novel structures of support-bound polymers are also disclosed.