Abstract: The invention relates to a charging device (1), more preferably an exhaust gas turbocharger for a motor vehicle, which turbine geometry comprises guide blades (5) rotatably mounted in a blade bearing ring (4), wherein the blade bearing ring (4) with a side is directly exposed to a hot gas flow (12) while the side of the blade bearing ring (4) facing away from this is only indirectly exposed to the hot gas flow (12). It is substantial to the invention that the blade bearing ring (4) on its side directly exposed to the hot gas flow (12) is produced of a different material than on its side only indirectly exposed to the hot gas flow (12) wherein the two materials with regard to their heat expansion coefficients are selected in such a manner that the blade bearing ring (4) at preferentially all occurring operating temperatures expands evenly without warping.

Abstract: The guide blades provided for the variable turbine geometry are adjustably arranged within a radial gap through which gases can flow on a moveable carrier ring, which is axially clamped against stops on or in the radial gap with a thrust spring device. According to the invention, the thrust spring device loads the carrier ring on the positions closely adjacent to the stops. The thrust spring device is designed open without sealing function and if applicable combined with a separate seal without thrust function.

Abstract: The invention relates to a piece of charging equipment having a variable turbine geometry (1), which has guide vanes (3, 4) that are rotatably mounted between a guide vane carrier (2) and a cover disc, wherein the cover disc is fixed/positioned on the guide vane carrier (2) by means of spacers (5) and wherein the variable turbine geometry (1) has at least two different types of flow channels (6, 7), namely a first flow channel (6) in which a flow behaviour is influenced by an associated spacer (5), and a second flow channel (7) in which a flow behaviour is not influenced by the spacers (5).

Abstract: Disclosed is an attachment (100) for a cup (200) having a body (210), a base (220) and a mouth (230) delimited by a rim (240). The attachment comprises a chamber (110) for holding an infusion bag (300) and comprising a wall (111) delimiting a cavity (112) for receiving the infusion bag (300) and a mouth (113) for allowing the infusion bag (300) to pass into the cavity (112). The attachment further comprises an element (120) for suspending the chamber (110) within the cup (200) such that at least a portion of the mouth (113) of the chamber (110) is below the rim (240) of the cup (200). The element (120) and chamber (110) are arranged such that when the chamber (110) is suspended in the cup (200), liquid (400) cannot pass between the cup and the chamber when the cup is substantially full.

Abstract: The invention relates to a turbine, in particular of an exhaust-gas turbocharger, comprising a turbine rotor which is supported rotatable in a housing, and to which at least one guide vane apparatus forming a radial inlet channel for a medium driving the turbine rotor is allocated, wherein the guide vane apparatus comprises a guide vane mounting ring with a plurality of guide vanes which radially surround the turbine rotor and which are located within the inlet channel, as well as a guide vane cover ring, and wherein the inlet channel is axially bounded by the guide vane mounting ring and the guide vane cover ring, and the guide vane cover ring abuts with a front side facing away from the inlet channel against a support area of the housing. The invention provides that the housing (5) comprises in the support area (15) at least one recess (17) which is open-edged towards the guide vane cover ring (9), and through which the medium can flow.

Abstract: The present invention relates to pyridylpyrimidine derivatives of the general formula (I): wherein R represents hydrogen or methyl and Z represents nitrogen containing functional groups, the use of the pyridylpyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of prion infections and prion diseases, as well as compositions containing at least one pyridylpyrimidine derivative and/or pharmaceutically acceptable salt thereof. Furthermore, the present invention is directed to methods for preventing and/or treating prion infections and prion diseases using said pyridylpyrimidine derivatives. Human cellular protein kinases, phosphatases and cellular signal transduction molecules are disclosed as targets for detecting, preventing and/or treating prion infections and diseases, especially BSE, vCJD, or CJD which can be inhibited by the inventive pyridylpyrimidine derivatives.

Abstract: The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g.

Abstract: The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular kinase inhibitors. Cellular kinases inhibitors, which effectively downregulate these key cellular components, serve as effective therapeutics against HCMV infection.

Abstract: The present invention relates to pyridylpyrimidine derivatives of the general formula (I): 1

Abstract: The present invention relates to a method for the identification of kinase inhibitors which is suitable for high-throughput screening. Moreover, the inhibitory effect of test substances can be quantified and a potential cytotoxicity of the respective inhibitors can be detected. The method is particularly suitable for the identification of inhibitors of viral kinases, e.g. herpes viral kinases.

Abstract: The role of certain cellular kinases active during Human Cytomegalovirus infection is disclosed. These cellular kinases are useful to detect HCMV infection, and can be used to screen for cellular kinase inhibitors. Cellular kinases inhibitors, which effectively downregulate these key cellular components, serve as effective therapeutics against HCMV infection.

Abstract: From a body located at a distance above the surface of the earth, an image is recorded of a region that is located underneath the body on or above the surface of the earth and that has a diameter of at least one kilometer. The recorded image is fully geocoded and comprises a grid dimension small enough that vehicle densities located in the region can be recognized. The recorded image is evaluated with respect to these vehicle densities and the spatial allocation thereof to the associated roadways. The method is used for acquisition of the state of street traffic over a large area.