Patents by Inventor Matthias Versele

Matthias Versele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD
    Patent number: 12030866
    Abstract: The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.
    Type: Grant
    Filed: December 23, 2022
    Date of Patent: July 9, 2024
    Assignees: SPRINGWORKS THERAPEUTICS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN, VIB VZW
    Inventors: Bart Vanderhoydonck, Arnaud Marchand, Stephen L. Gwaltney, Stéphane Spieser, Wim Smets, Aurélie Candi, Matthias Versele, Georg Halder
  • IBRUTINIB COMBINATION THERAPY
    Publication number: 20200368235
    Abstract: Combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with a second anticancer agent are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Bruton's tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and second anticancer agents.
    Type: Application
    Filed: August 1, 2019
    Publication date: November 26, 2020
    Inventors: Betty Chang, Sriram Balasubramanian, Richard Crowley, Hsu-Ping Kuo, Brett Hall, Kate A. Sasser, Tineke Casneuf, Michael Schaffer, Matthias Versele, Willem Ligtenberg, Cue Davis
  • Strains "fil", stress-resistant under fermentation and/or growth conditions
    Publication number: 20040175831
    Abstract: The invention relates to new eukaryotic strains, preferably yeast strains, having the new fil phenotype, i.e. having the unexpected property of conserving good stress resistance in fermentation and/or growth phase, while conserving normal respiratory and fermentation metabolism on fermentable sugars such as glucose.
    Type: Application
    Filed: March 10, 2004
    Publication date: September 9, 2004
    Applicant: LESAFFRE ET CIE
    Inventors: Johan Thevelein, Marie-Francoise Gorwa, Patrick Van Dijck, Francoise Dumortier, Aloys Teunissen, Katleen Lemaire, Didier Colavizza, Matthias Versele, Annie Loiez