Abstract: Pharmaceutical micronutrient composition including mixture D in this study helps to mitigate, inhibit, prevent and stop diseases caused by viral infections. The middle east respiratory syndrome-related coronavirus and severe acute respiratory syndrome-related coronavirus as well as their variants and mutants affecting mammals and causing infection are successfully treated using mixture D. Mixture D contains key micronutrients such as an ascorbate, N-acetylcysteine, theaflavins, resveratrol, cruciferous plant extracts, curcumin, quercetin, naringenin, and baicalin and a combination thereof. Additional micronutrients were tested with Mixture D and seemed to have beneficial effects.

Abstract: The study shows that ascorbic acid and its combination with some natural compounds could be included in developing preventive and therapeutic approaches toward the current pandemic. Some natural compounds were effective in lowering ACE2 cellular expression, with the highest inhibitory effects observed for baicalin (75%) and theaflavin (50%). Significantly, combinations of these and other test compounds with ascorbic acid further decreased ACE2 expression. The highest impact of ascorbate on ACE2 expression was noted when combined with theaflavin (decrease from 50% to 87%), zinc aspartate (decrease from 22% to 62%), and with 10-undecenoic acid (from 18% to 53%). Our study provides valuable experimental confirmation of the efficacy of micronutrients in controlling ACE2 expression—the coronavirus cellular “entry” point. It further validates the importance of nutrient interactions in various aspects of cellular metabolism and in considering potential therapeutic applications of nutrient-based approaches.

Abstract: The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides, SEQ ID NO: wherein the matrix metalloproteinase oligopeptide is at least one of SEQ ID NO: 7, 11, 12, 18 and 19 and combination thereof. These oligopeptides are bound to antibodies to create an immune response in the subject mammal against the matrix metalloproteinases of various diseases. The instance method is a means of therapeutic intervention against the disease spread created by the matrix metalloproteinases. Further use of these oligopeptide-antibody responses can be extended to any and all diseases that use the matrix metalloproteinases to aid in their pathogenicity.

Abstract: A pharmaceutical composition in a physiological dose for a mammal is used for reducing vascular calcification caused due to statin consumption. The composition contains mixture 1 and statin. The mixture 1 contains combination of the Vitamin C, Vitamin E, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6, Vitamin B12, Folic acid, Biotin, L-carnitine and Betaine. The mixture 1 can be used as a stand-alone product with or without statin.

Abstract: The nutrient mixture made up of vitamin, carotenoid, micronutrient, essential trace element, and plant extract was much more effective in proactively protecting the corneal cells (human) and retinal pigment endothelial cells (rat) against damaging effects of H2O2 and glycosylated proteins (AGE-BSA) compared to its individual components. A mixture is made up of vitamin A, vitamin C, vitamin E, Lycopene, lutein, marigold flower extract, a saffron extract, pine bark extract, grape seed extract, bilberry extract, lipoic acid, L-Arginine and zinc.

Abstract: A mixture, comprising at least three, two or four different chemical compounds, selected from the group eicosapentaenoic acid, usnic acid, norspermidine, clove oil and 10-undecynoic acid is used in dental health compositions. The mixture is used for dental hygiene for controlling Streptococcus mutans and Candida albicans.

Abstract: A composition of natural and chemical nutrients such as Vitamin C, Vitamin B-complex, Vitamin E, Aronia melanocarpa extract, Fucoidan, Ginger extract, Zinc, Selenium, Alpha lipoic acid, White mulberry extract, Lychee fruit extract and Sour (Tart) cherry fruit extract are made for mammal consumption in liquid or solid form. This specific composition is used for increasing innate immunity in the mammal before and after the infection has occurred.

Abstract: A mixture, comprising at least four different chemical compounds, selected from the group consisting of calcium ascorbate, tocopherol acetate, coenzyme Q10, eicosapentaenoic acid, usnic acid, L-carnitine fumarate and norspermidine, is used in dental health compositions. The mixture when used for dental hygiene has bactericidal and bacteriostatic effectiveness against S. mutans and S. sorbinus.

Abstract: The nutrient mixture made up of vitamin, carotenoid, micronutrient, essential trace element, and plant extract was much more effective in proactively protecting the corneal cells (human) and retinal pigment endothelial cells (rat) against damaging effects of H2O2 and glycosylated proteins (AGE-BSA) compared to its individual components. A mixture is made up of vitamin A, vitamin C, vitamin E, Lycopene, lutein, marigold flower extract, a saffron extract, pine bark extract, grape seed extract, bilberry extract, lipoic acid, L-Arginine and zinc.

Abstract: A composition of a fatty acids, essential oils, plant extracts, phenols, and terpenoids and used for treating Lyme disease is disclosed. Compositions as a mix of ingredients was tested in various combinations and concentration against active (spirochetes), as well as persistent/latent forms, (knob-shaped/rounded-forms) and biofilm of the bacteria, i.e., Borrelia burgdorferi and Borrelia garinii. The results document pleiotropic effects of the tested combinations against all tested forms of Borrelia sp. and show their better efficacy than doxycycline—the current antibiotic treatment against Lyme disease.

Abstract: A therapeutic use of ascorbyl palmitate, ascorbic acid and/or derivatives thereof to reverse or counter the adverse effects of channel blockers in the medical management of cardiovascular disease in a subject is presented. Effects of select Na- and Ca-channel blockers on collagen synthesis and deposition were evaluated in cultured human dermal fibroblasts and aortic smooth muscle cells by immunoassay. Ca and Na-channel blockers inhibited the synthesis of collagen type I and collagen type IV, the basic molecules of vascular wall stability. The inhibitory effects of the calcium and sodium channel blockers on collagen synthesis was reversed by introducing ascorbic acid and/or ascorbyl palmitate. It can be concluded that calcium and sodium channel blockers have a direct inhibitory effect on collagen synthesis, favoring the instability of the vascular wall and the progression of cardiovascular disease, an effect that is mitigated by treatment with, ascorbyl palmitate, ascorbic acid and or derivatives thereof.

Abstract: Lyme disease caused by B. burgdorferi and B. garinii has been traditionally treated with antibiotics. However, to eradicate all three morphological forms of Borrelia species such as spirochetes, rounded bodies and biofilm more effective and safe treatment plan is required. In the instant application, Vitamins and Phytobiologicals have been tested for as a short term and long term treatment in vitro and on biofilm. The combination of tested compounds in form of Mix AO seems to be very beneficial in treating Lyme disease caused by B. burgdorferi and B. garinii.

Abstract: A composition for treating Lyme disease caused by Borrelia Species, comprising a vitamin, a small fatty acid signaling molecule, an essential amino acid, a flavonoid, a plant extract and a mineral.

Abstract: A method and technology to display 3D graphical output for a user using body sensor data, personal medical data in real time is disclosed. A consolidated methodology to bring user meaningful life information based on real-time sensor results, analysis, expert Q&As, “What if” scenarios and future emulation all in one artificial intelligence expert system is described. A unique rendering of 3D image of ones organ, cell or subcellular level display related to one's health condition can be visualized on a graphical user interface of a devices or devices. The change of the display from one level such as from organ to cell or cell to subcellular level or vice versa is enabled is disclosed.

Abstract: A method and technology to display 3D graphical output for a user using body sensor data, personal medical data in real time is disclosed. A consolidated methodology to bring user meaningful life information based on real-time sensor results, analysis, expert Q&As, “What if” scenarios and future emulation all in one artificial intelligence expert system is described. A unique rendering of 3D image of ones organ, cell or subcellular level display related to one's health condition can be visualized on a graphical user interface of a devices or devices. The change of the display from one level such as from organ to cell or cell to subcellular level or vice versa is enabled is disclosed.

Abstract: The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and/or treatment of human diseases.

Abstract: The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and/or treatment of human diseases.

Abstract: The invention discloses novel model of transgenic mammal, a method of crossbreeding transgenic mammal and the use of the transgenic mammal for assessing prevention and/or treatment methods for cardiovascular and other diseases related to lipoprotein(a). The transgenic mammal expresses human apolipoprotein (a) (apo(a)) and human apolipoprotein B-100 (apo B-100) genes and produces human lipoprotein (a), apo (a) and apo B-100 and produces no vitamin C. This novel dual transgenic mammal is the ideal model for testing pharmaceutical compounds for efficacy and usefulness in the prevention and/or treatment of human diseases.

Abstract: Several methods, processes and system for modular tool as an integrated multimedia tool system to explore and study the virtual human body is disclosed. Content and context modules allow for scientific gaming using modular multimedia objects, social media and different configurations. The disclosure allows an individual to travel through the virtual human body in a self guided and interactive tour. It specifically enables the user to learn the structure and function of different organs, different types of cells, intercellular space as well as different cellular organelles etc. Further, the system may be used by the local authority as an electronic study tool for seamless integrated mode of delivering the educational tool suited to the local curriculum. This may also serve as a tool for patients, doctors, focus groups and student to explore and learn about the pathological and physiological conditions in a human body.

Abstract: The invention discloses identification and therapeutic use of matrix metalloproteinase oligopeptides, SEQ ID wherein the matrix metalloproteinase oligopeptide is at least one of SEQ ID 7, 11, 12, 18 and 19 and combination thereof. These oligopeptides are bound to antibodies to create an immune response in the subject mammal against the matrix metalloproteinases of various diseases. The instance method is a means of therapeutic intervention against the disease spread created by the matrix metalloproteinases. Further use of these oligopeptide-antibody responses can be extended to any and all diseases that use the matrix metalloproteinases to aid in their pathogenicity.