Abstract: An X-ray detection system is described having a solid-state detector module including a plurality of detector tiles at a first side thereof for directly detecting X-ray radiation. The detector module has a plurality of interstitial areas separating adjacent tiles of the detector module, and at least one actuator for inducing motion of the detector module to a plurality of detection positions along a trajectory with respect to a stationary reference frame while the detector module is operated in an exposure mode. The spatial extent of the trajectory in the stationary reference frame is at least as large as the largest interstitial area, and the detector module is adapted for acquiring a plurality of frames in the exposure mode at a frame acquisition rate at least a factor of 100 faster than the inverse of a predetermined exposure time for the exposure mode.