Abstract: A method and system are provided for reconstructing a motion-compensated nuclear image of a subject, as well as an arrangement for method. The reconstruction method comprises receiving nuclear image data the acquiring a nuclear image, and a computer program for carrying out the for multiple motion states, reconstructing the data into an image for each motion state, and calculating a deformation vector field for each state for mapping the image onto a reference motion state. Calculating the deformation vector field comprises providing an initial vector field, defining at least one rigid region of the subject, incorporating that rigid region into the initial vector field, and calculating the deformation vector field with the incorporated rigid region. The method further comprises mapping the reconstructed image of each motion state onto the reference state using the deformation vector fields; and combining the mapped images into a motion-compensated nuclear image.