Patents by Inventor Matti Leisola

Matti Leisola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to improve the stability and broaden the pH range of family G/11 xylanases
    Patent number: 9481874
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: November 1, 2016
    Inventors: Fred Fenel, Ossi Turunen, Matti Leisola
  • METHOD TO IMPROVE THE STABILITY AND BROADEN THE PH RANGE OF FAMILY G/11 XYLANASES
    Publication number: 20150011743
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 8, 2015
    Applicant: DANISCO US INC.
    Inventors: Fred FENEL, Ossi TURUNEN, Matti LEISOLA
  • Method to improve the stability and broaden the pH range of family G/11 xylanases
    Patent number: 8846364
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: September 30, 2014
    Assignee: Danisco US Inc.
    Inventors: Fred Fenel, Ossi Turunen, Matti Leisola
  • METHOD TO IMPROVE THE STABILITY AND BROADEN THE PH RANGE OF FAMILY G/11 XYLANASES
    Publication number: 20130288335
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Application
    Filed: March 22, 2013
    Publication date: October 31, 2013
    Inventors: Fred FENEL, Ossi TURUNEN, Matti LEISOLA
  • Method to improve the stability and broaden the pH range of family G/11 xylanases
    Patent number: 8426181
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: April 23, 2013
    Assignee: Danisco US Inc.
    Inventors: Fred Fenel, Ossi Turunen, Matti Leisola
  • G/11 xylanases with improved stability
    Patent number: 7718411
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: May 18, 2010
    Assignee: Danisco US Inc.
    Inventors: Fred Fenel, Ossi Turunen, Matti Leisola
  • Method to Improve the Stability and Broaden the pH range of family G/11 xylanases
    Publication number: 20080171374
    Abstract: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-?-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to match the industrial conditions where it is used. Protein engineering can be used to improve thermoactivity and thermostability of xylanases, as well as to broaden their pH range.
    Type: Application
    Filed: December 21, 2007
    Publication date: July 17, 2008
    Inventors: Fred Fenel, Ossi Turunen, Matti Leisola
  • Process for chromatographic separation of nucleosides
    Publication number: 20050176110
    Abstract: The invention relates to a process for chromatographic separation and purification of natural and synthetic nucleosides, deoxynucleosides and corresponding bases by using cross-linked xylose isomerase. In particular, nucleosides are separated from biological material, especially industrial side streams.
    Type: Application
    Filed: May 30, 2003
    Publication date: August 11, 2005
    Applicant: TEKNILLINEN KORKEAKOULU
    Inventors: Matti Leisola, Jouni Jokela
  • Yeast strains for the production of xylitol
    Patent number: 6271007
    Abstract: The invention relates to novel yeast strains having a reduced ability to metabolize xylitol. The invention further relates to the use of said strains for the production of xylitol.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: August 7, 2001
    Assignee: Xyrofin Oy
    Inventors: Juha Apajalahti, Matti Leisola