Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: The present invention relates to compounds of formula (I) wherein: Ar1 or Ar2 is an optionally substituted indole, and the other group is an optionally substituted aromatic or heteroaromatic group, preferably an optionally substituted indole, X is O or S, and R2 is H, hydroxy, amino, C1-6alkyl, hydroxyC1-6alkyl or aminoC1-6alkyl, and salts and solvates thereof and solvates of such salts, and the use of such compounds in medical therapies.

Abstract: The present invention relates to compounds of formula (I): wherein: Ar is an optionally substituted aromatic or heteroaromatic group, R1 is H, C1-6alkyl, CF3, phenyl, benzyl, carboC1-6alkoxy, carbamoyl, or methyl(N—C1-6alkylcarbamoyl) R2 is H, C1-6alkyl, aminoC1-6alkyl, hydroxyC1-6alkyl, (mono- or di- C1-6alkyl)aminoC1-6alkyl, (aminoC1-3alkylphenyl)C1-3alkyl, amidinothio C1-6alkyl, R3 is H or C1-6alkoxy, R4 is H or together with R2, forms an annulated ring which may be substituted by hydroxyC1-3alkyl or amidinothio C1-3alkyl, or aminoC1-3alkyl; and pharmaceutically acceptable salts thereof; and the use of such compounds in medical therapies.

Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Abstract: A method and device for contact-free treatment of a web in which the web is treated, for example supported, reversed, spread, carried, and/or dried, by blowings which provide a carrier-face zone. The carrier-face zone has a curved form regulatable in a direction transverse to the direction of progress of the web. The nozzle-carrier face unit of the device is bent to the curved form in the cross direction of the machine while a frame part of the device is kept in a stationary position. The device includes a regulation arrangement for bending the nozzle-carrier-face unit to a curve form in the direction transverse to the running direction of the web while the frame part of the device is supported in a stationary position.

Abstract: A method for contact-free drying of a paper or board web or of any other corresponding continuous web. During drying, both infrared radiation and drying air jets are used. The web is carried by the air jets through the dryer free of contact. The moving web is first passed into an infrared drying gap, in which a drying energy pulse of relatively short duration is directed at the web, the power of the energy pulse being substantially higher than the average drying power of the dryer per unit of area. After the infrared drying gap, the web is immediately passed into an airborne web drying gap wherein the web is supported and dried by means of air jets. Air is brought into the infrared unit, which air having been heated in the infrared unit is passed as replacement air and/or drying air for the airborne web drying unit or units placed after the infrared unit.

Abstract: An arrangement of pressure nozzles intended for the treatment of webs comprises a nozzle box. The nozzle box has a carrying face (16) placed facing the web, two nozzle slots (17,18) that blow towards each other being provided in connection with the carrying face, these nozzle slots being placed in the outer part of the space defined by the inner walls (14,15) and the outer walls (20,21) of the nozzle box. The arrangement of nozzles is asymmetric relative to the perpendicular center plane (A--A) of its pressurized carrying face (16). The arrangement of nozzles has a first nozzle slot (18), which is placed relative the carrying face (16) in such a way that the gas jet (v.sub.1) blown out of the nozzle slot follows and remains in contact with the curved carrying face (16) up to the area between the nozzle slots (17,18). The arrangement of nozzles includes a second nozzle slot (17), which is placed within the area of the edge of the curved guide face (14,R.sub.