Patents by Inventor Matti Sarvas

Matti Sarvas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein secretion
    Patent number: 6451560
    Abstract: The invention relates to a novel prokaryotic expression system characterized by alterations to the dlt operon whereby expression of genes encoded therein may be regulated to limit the availability of polypeptides encoded by said genes.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: September 17, 2002
    Inventors: Colin R. Harwood, Keith Stephenson, Vesa Kontinen, Matti Sarvas
  • Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria
    Patent number: 5945278
    Abstract: The invention provides a method and expression system for enhancing secretion of hyperproduced homologous and heterologous exoproteins in gram-positive bacteria such as Bacillus sp. The method and system comprise overproduction of PrsA protein in a gram-positive bacterial host also overproducing at least one exoprotein of interest. Use of the method and system of the invention results in greatly enhanced secretion of the synthesized exoproteins into the growth medium. Once in the growth medium these secreted exoproteins can be recovered and purified in a straightforward manner.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: August 31, 1999
    Assignee: The Finnish National Public Health Institute
    Inventors: Vesa Kontinen, Matti Sarvas
  • Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria
    Patent number: 5780261
    Abstract: The invention provides a method and expression system for enhancing secretion of hyperproduced homologous and heterologous exoproteins in gram-positive bacteria such as Bacillus sp. The method and system comprise overproduction of PrsA protein in gram-positive bacterial host capable of also overproducing at least one exoprotein of interest. Use of the method and system of the invention results in greatly enhanced secretion of the synthesized exoproteins into the growth medium. Once in the growth medium these secreted exoproteins can be recovered and purified in a straightforward manner.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: July 14, 1998
    Assignee: The Finnish National Public Health Institute (KTL)
    Inventors: Vesa Kontinen, Matti Sarvas