Patents by Inventor Matti Siika-Aho
Matti Siika-Aho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210388398Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.Type: ApplicationFiled: December 22, 2020Publication date: December 16, 2021Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willies, John Bardsley, Anu Koivula, Sanni Voutilainen
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Patent number: 10266610Abstract: The present invention relates to a method of treating biomass, comprising providing a lignocellulosic biomass feedstock; contacting the biomass feedstock in a mixture, which is formed by the biomass, water and an alkaline agent, with an oxidizing agent at an elevated temperature; and continuing the contacting of the biomass feedstock with the oxidizing agent until a notable part of the lignin is solubilized. The step of providing the biomass feedstock comprises contacting a biomass raw-material containing cellulose, hemicellulose and lignin in an aqueous phase with an alkaline agent; continuing the contacting of the biomass with the alkaline agent until a significant portion of the hemicellulose is dissolved in the aqueous phase to provide a modified biomass; recovering the modified biomass; optionally opening the structure of the modified biomass by mechanical treatment; and using the modified biomass as a lignocellulosic biomass feedstock.Type: GrantFiled: October 19, 2015Date of Patent: April 23, 2019Assignee: TEKNOLOGIAN TUTKIMUSKESKUS VTT OYInventors: Antero Varhimo, Matti Siika-Aho, Jari Sirviö, Sari Liukkonen, Marjo Määttänen
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Publication number: 20180258449Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluyveromyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.Type: ApplicationFiled: May 21, 2018Publication date: September 13, 2018Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willies, John Bardsley, Anu Koivula, Sanni Voutilainen
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Patent number: 9988652Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterologous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.Type: GrantFiled: July 1, 2015Date of Patent: June 5, 2018Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch UniversityInventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
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Publication number: 20180044656Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: ApplicationFiled: August 30, 2017Publication date: February 15, 2018Inventors: Jari Vehmaanpera, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Jamsa, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Publication number: 20170298152Abstract: The present invention relates to a method of treating biomass, comprising providing a lignocellulosic biomass feedstock; contacting the biomass feedstock in a mixture, which is formed by the biomass, water and an alkaline agent, with an oxidizing agent at an elevated temperature; and continuing the contacting of the biomass feedstock with the oxidizing agent until a notable part of the lignin is solubilised. The step of providing the biomass feedstock comprises contacting a biomass raw-material containing cellulose, hemicellulose and lignin in an aqueous phase with an alkaline agent; continuing the contacting of the biomass with the alkaline agent until a significant portion of the hemicellulose is dissolved in the aqueous phase to provide a modified biomass; recovering the modified biomass; optionally opening the structure of the modified biomass by mechanical treatment; and using the modified biomass as a lignocellulosic biomass feedstock.Type: ApplicationFiled: October 19, 2015Publication date: October 19, 2017Inventors: Antero Varhimo, Matti Siika-Aho, Jari Sirviö, Sari Liukkonen, Marjo Määttänen
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Patent number: 9758777Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: GrantFiled: February 22, 2013Date of Patent: September 12, 2017Assignee: Roal OYInventors: Jari Vehmaanperä, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Hooman, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Patent number: 9593324Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: GrantFiled: October 3, 2013Date of Patent: March 14, 2017Assignee: Roal OyInventors: Jari Vehmaanperä, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Jamsa, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Publication number: 20160010117Abstract: The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.Type: ApplicationFiled: July 1, 2015Publication date: January 14, 2016Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
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Patent number: 9102955Abstract: Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processes.Type: GrantFiled: November 23, 2009Date of Patent: August 11, 2015Assignee: Lallemand Hungary Liquidity Management LLCInventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
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Publication number: 20140322762Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: ApplicationFiled: October 3, 2013Publication date: October 30, 2014Applicant: ROAL OYInventors: Jari VEHMAANPERÄ, Marika ALAPURANEN, Terhi PURANEN, Matti SIIKA-AHO, Jarno KALLIO, Satu HOOMAN, Sanni VOUTILAINEN, Teemu HALONEN, Liisa VIIKARI
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Publication number: 20130327319Abstract: The present invention concerns a process for the mechanical or mechano-chemical treatment of biomass, wherein a mixture containing the biomass and optional further chemicals is pressed through the openings of one or more compactor one or more times. The process can be operated in a continuous manner by using more than one compactor and more than one compacting cycle, whereby the multiple compactors are operated sequentially.Type: ApplicationFiled: February 23, 2012Publication date: December 12, 2013Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTTInventors: Kirsi Immonen, Eino Sivonen, Kyosti Valta, Anne Kallioinen, Matti Siika-Aho
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Publication number: 20130224801Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: ApplicationFiled: February 22, 2013Publication date: August 29, 2013Applicant: ROAL OYInventors: Jari VEHMAANPERÄ, Marika ALAPURANEN, Terhi PURANEN, Matti SIIKA-AHO, Jarno KALLIO, Satu HOOMAN, Sanni VOUTILAINEN, Teemu HALONEN, Liisa VIIKARI
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Patent number: 8409836Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: GrantFiled: November 2, 2010Date of Patent: April 2, 2013Assignee: Roal OyInventors: Jari Vehmaanperä, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Hooman, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Publication number: 20120129229Abstract: Host cells, comprising Kluveryomyces expressing heterologous cellulases produce ethanol from cellulose In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose The recombinant yeast strains and co-cultures of the yeast strains can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of sacchanfication and fermentation processesType: ApplicationFiled: November 23, 2009Publication date: May 24, 2012Inventors: John McBride, Elena Brevnova, Mark Mellon, Allan Froehlich, Kristen Deleault, Vineet Rajgarhia, Riaan Den Haan, Merja Penttila, Marja Ilmen, Matti Siika-Aho, Jaana Uusitalo, Emily A. Stonehouse, Alan Gilbert, Haowen Xu, Deidre Willes, John Bardsley, Anu Koivula, Sanni Voutilainen
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Publication number: 20110045544Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: ApplicationFiled: November 2, 2010Publication date: February 24, 2011Applicant: Roal OYInventors: Jari Vehmaanperä, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Hooman, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Patent number: 7754456Abstract: A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.Type: GrantFiled: June 6, 2005Date of Patent: July 13, 2010Assignee: Valtion Teknillinen TutkimuskeskusInventors: Merja Penttilä, Matti Siika-Aho, Jaana Uusitalo, Liisa Viikari
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Publication number: 20090042266Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.Type: ApplicationFiled: June 19, 2008Publication date: February 12, 2009Applicant: Roal OyInventors: Jari VEHMAANPERA, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Hooman, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
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Publication number: 20080044877Abstract: A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.Type: ApplicationFiled: June 6, 2005Publication date: February 21, 2008Inventors: Merja Penttila, Matti Siika-Aho, Jaana Uusitalo, Liisa Viikari
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Patent number: 7256032Abstract: The present invention relates to novel cellulase enzymes, especially novel endoglucanases including endoglucanase fusion proteins, preparations and compositions containing these endoglucanase enzymes and fusion proteins, expression vectors, host cells and methods for their preparation and uses of the cellulases, preparations and compositions in the textile, detergent and pulp and paper industries.Type: GrantFiled: December 22, 2005Date of Patent: August 14, 2007Assignee: AB Enzymes OyInventors: Leena Valtakari, Marika Alapuranen, Satu Hooman, Matti Siika-Aho, Jarno Kallio, Liisa Viikari, Pentti Ojapalo, Jari Vehmaanperä