Patents by Inventor Mattia Bertolotti

Mattia Bertolotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF ZANUBRUTINIB
    Publication number: 20240425510
    Abstract: It is described a process for the preparation of Zanubrutinib, a drug used for the treatment of adult patients suffering from mantle cell lymphoma (MCL) or Waldenström macroglobulinemia.
    Type: Application
    Filed: October 10, 2022
    Publication date: December 26, 2024
    Applicant: OLON S.P.A.
    Inventors: Alessia MANFREDI, Mattia BERTOLOTTI, Valentina GRANDE, Barbara NOVO
  • Method for the preparation of pimavanserin base
    Patent number: 11319288
    Abstract: Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: May 3, 2022
    Assignee: OLON S.P.A.
    Inventors: Barbara Novo, Jacopo Bonanomi, Mattia Bertolotti
  • Efficient method for the preparation of Cangrelor
    Patent number: 11279724
    Abstract: Disclosed is a process for the preparation of Cangrelor in salt form by preparation and subsequent hydrolysis of an intermediate of formula (IV): The process is characterized by the high yield and purity of the product, and can be used industrially.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: March 22, 2022
    Assignee: OLON S.P.A.
    Inventors: Jacopo Bonanomi, Mattia Bertolotti, Barbara Novo
  • EFFICIENT METHOD FOR THE PREPARATION OF CANGRELOR
    Publication number: 20210179654
    Abstract: The present invention relates to a process for the preparation of Cangrelor in salt form of formula (V) by preparation and subsequent hydrolysis of an intermediate of formula (IV). The process is characterised by the high yield and purity of the product, and can be used industrially.
    Type: Application
    Filed: October 29, 2018
    Publication date: June 17, 2021
    Inventors: Jacopo BONANOMI, Mattia BERTOLOTTI, Barbara NOVO
  • AMORPHOUS FORM OF PIMAVANSERIN HEMITARTRATE
    Publication number: 20210171464
    Abstract: Disclosed is the amorphous form of pimavanserin* hemitartrate, the process for its preparation, and pharmaceutical formulations containing it.
    Type: Application
    Filed: October 29, 2018
    Publication date: June 10, 2021
    Inventors: Mattia BERTOLOTTI, Jacopo BONANOMI, Barbara NOVO
  • METHOD FOR THE PREPARATION OF PIMAVANSERIN BASE
    Publication number: 20210130296
    Abstract: Disclosed is a process for the synthesis of pimavanserin base with a high yield and purity, which comprises: a) converting tert-butyl-N-[(4-propan-2-yloxyphenyl)methyl]carbamate (Formula (I)) to 1-(isocyanatomethyl)-4-propan-2-yloxybenzene of formula (II) b) adding N-[(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine (Formula (IV)) to the solution obtained in a) to give pimavanserin base, and c) purifying the pimavanserin base obtained in step b).
    Type: Application
    Filed: April 24, 2019
    Publication date: May 6, 2021
    Applicant: OLON S.P.A.
    Inventors: Barbara Novo, Jacopo Bonanomi, Mattia Bertolotti