Patents by Inventor Mattia Bonsignori

Mattia Bonsignori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 11884704
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 30, 2024
    Assignees: DUKE UNIVERSITY, TRIAD NATIONAL SECURITY, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin O. Saunders
  • Methods to identify immunogens by targeting improbable mutations
    Patent number: 11746143
    Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: September 5, 2023
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Kevin J. Wiehe, Mattia Bonsignori
  • ZIKA ANTIBODIES AND THEIR USE
    Publication number: 20220315646
    Abstract: The invention is directed to antibodies, and antigen-binding fragments thereof, that potently neutralize infection of ZIKV. The invention also relates to antigenic sites to which the antibodies and antigen-binding fragments bind, as well as to nucleic acids that encode the antibodies of the invention, and immortalized B cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of ZIKV infection.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: Sallie PERMAR, Mattia BONSIGNORI, Tulika SINGH, Kwan-Ki HWANG
  • METHODS TO IDENTIFY IMMUNOGENS BY TARGETING IMPROBABLE MUTATIONS
    Publication number: 20220185871
    Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.
    Type: Application
    Filed: October 13, 2021
    Publication date: June 16, 2022
    Inventors: Barton F. HAYNES, Kevin J. WIEHE, Mattia BONSIGNORI
  • Compositions and methods for inducing HIV-1 antibodies
    Patent number: 11246920
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections there—from, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 15, 2022
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • Methods to identify immunogens by targeting improbable mutations
    Patent number: 11161895
    Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: November 2, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Kevin J. Wiehe, Mattia Bonsignori
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20210277065
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 9, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin O. SAUNDERS
  • COMPOSITIONS AND METHODS FOR INDUCING HIV-1 ANTIBODIES
    Publication number: 20210187091
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH0848) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 24, 2021
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • Compositions comprising HIV envelopes to induce CH235 lineage antibodies
    Patent number: 10968255
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 6, 2021
    Assignees: Duke University, Triad National Security, LLC
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-Xin Liao, Bette T. Korber, Peter T. Hraber, Kevin Saunders
  • METHODS TO IDENTIFY IMMUNOGENS BY TARGETING IMPROBABLE MUTATIONS
    Publication number: 20200031908
    Abstract: The invention is directed to methods to identify improbable mutations in the heavy or light chain variable domain of an antibody, methods to identify antigens which bind to antibodies comprising such improbable mutations, and methods of using such antigens to induce immune responses.
    Type: Application
    Filed: October 3, 2017
    Publication date: January 30, 2020
    Applicant: Duke University
    Inventors: Barton F. HAYNES, Kevin J. WIEHE, Mattia BONSIGNORI
  • COMPOSITIONS COMPRISING HIV ENVELOPES TO INDUCE CH235 LINEAGE ANTIBODIES
    Publication number: 20200002383
    Abstract: In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelope selections from individual CH505, and methods for swarm immunizations using combinations of HIV-1 envelopes.
    Type: Application
    Filed: March 1, 2017
    Publication date: January 2, 2020
    Inventors: Barton F. HAYNES, Mattia BONSIGNORI, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER, Kevin SAUNDERS
  • HIV-1 neutralizing antibodies and uses thereof (CD4bs antibodies)
    Patent number: 10450368
    Abstract: The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding site (CD4bs) of HIV-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies of the invention or fragments thereof or any combination thereof. In certain aspects the invention provides methods to treat or prevent HIV-1 infection in a subject comprising administering to the subject a pharmaceutical composition comprising any one of the inventive antibodies or fragments thereof.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: October 22, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Hua-Xin Liao, Mattia Bonsignori
  • HIV-1 neutralizing antibodies and uses thereof (V3 antibodies)
    Patent number: 10344077
    Abstract: The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: July 9, 2019
    Assignee: DUKE UNIVERSITY
    Inventors: Barton F. Haynes, Ryan Meyerhoff, M. Anthony Moody, Hua-Xin Liao, Todd Bradley, Mattia Bonsignori
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (CD4bs ANTIBODIES)
    Publication number: 20180079801
    Abstract: The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding site (CD4bs) of HIV-1 gp120, their recombinant expression and purification and uses. In certain aspects, the invention provides a pharmaceutical composition comprising anyone of the antibodies of the invention or fragments thereof or any combination thereof. In certain aspects the invention provides methods to treat or prevent HIV-1 infection in a subject comprising administering to the subject a pharmaceutical composition comprising any one of the inventive antibodies or fragments thereof.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 22, 2018
    Inventors: Barton F. HAYNES, Hua-Xin LIAO, Mattia BONSIGNORI
  • HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (V3 ANTIBODIES)
    Publication number: 20180072797
    Abstract: The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 15, 2018
    Inventors: Barton F. HAYNES, Ryan MEYERHOFF, M. Anthony MOODY, Hua-Xin LIAO, Todd BRADLEY, Mattia BONSIGNORI
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20160271244
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: February 29, 2016
    Publication date: September 22, 2016
    Inventors: Barton F. Haynes, Hua-Xin Liao, Georgia Tomaras, Thomas B. Kepler, Kwan-Ki Hwang, S. Munir Alam, Yang Liu, T. Matt Holl, Guang Yang, Garnett Kelsoe, Mattia Bonsignori
  • ADCC-MEDIATING ANTIBODIES, COMBINATIONS AND USES THEREOF
    Publication number: 20150239961
    Abstract: The present invention relates, in general, to antibody-dependent cellular cytoxicity (ADCC)-mediating antibodies, and, in particular, to ADCC-mediating antibodies (and fragments thereof) suitable for use, for example, in reducing the risk of HIV-1 infection in a subject. The invention further relates to compositions comprising such antibodies or antibody fragments.
    Type: Application
    Filed: September 26, 2013
    Publication date: August 27, 2015
    Inventors: Barton F. Haynes, Mattia Bonsignori, Hua-xin Liao, Guido Ferrari, Michael A. Moody, Jerome Kim, Nelson Michael, Justin Pollara
  • METHOD FOR THE GENERATION OF MONOCLONAL ANTIBODIES DERIVED FROM HUMAN B CELLS
    Publication number: 20130029424
    Abstract: The present invention relates, in general, to human B cells, and, in particular to a method of immortalizing and cloning human B cells and to monoclonal antibodies derived therefrom. The invention further relates to methods of using the monoclonal antibodies for therapeutic and diagnostic purposes.
    Type: Application
    Filed: April 11, 2011
    Publication date: January 31, 2013
    Inventors: Barton F. Haynes, Mattia Bonsignori, Kwan-Ki Hwang, Hua-Xin Liao, David C. Montefiori, Micah A. Luftig
  • METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES
    Publication number: 20120321699
    Abstract: The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell germline and clone intermediates using a combination of HIV envelope and non-HIV immunogens. The invention also relates to compositions suitable for use in such a method.
    Type: Application
    Filed: February 25, 2011
    Publication date: December 20, 2012
    Inventors: Barton F. Haynes, Hua-Xin Liao, Georgia Tomaras, Thomas B. Kepler, Kwan-Ki Hwang, S.Munir Alam, Yang Liu, T. Matt Holl, Guang Yang, Garnett Kelsoe, Mattia Bonsignori