Abstract: A flexible electrode (1) for applying an electric field to the human body, comprising: a gripping portion (3); a deformable structure (5) having a first face (5a) fixed to the gripping portion (3); a flexible polymeric film (7) arranged on a flat second face (5b) of the deformable structure (5) and provided, on a flat face (7a) thereof facing outwards the electrode (1), with flat metal structures (10,11) defining at least one first electrode and one second electrode (A,B), surfaces (10a,11a) of the flat metal structures (10,11) facing outwards the polymeric film (7) being coplanar with the flat face (7a) of the polymeric film (7).

Abstract: A handling and control system for expandable electrodes of a handpiece is provided that includes a plurality of flexible electrodes made of elastic cables carried by a support assembly with needle-shaped front portions that protrude from the support assembly and move in a three-dimensional space under the push of actuators.

Abstract: A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

Abstract: The present invention relates to a plasmid comprising a sequence encoding for a fragment of p185neu chosen in the group consisting of SEQ ID 1, 2, 3, 4, 5, 6 carried by applying a pulsating voltage having an intensity comprised in the range from 100 to 200 V, through a needle electrode for use in the preventive or therapeutic treatment of subjects at risk of developing p185neu-positive tumors, or of patients with p185neu-positive primary tumors, metastasis or relapses.

Abstract: A method for controlling an electroporation device configured for supplying an electrical power signal to a plurality of pairs of electrodes coupled to a portion of the human body, wherein the following steps are performed: detecting, in the course of an electroporation treatment, a condition of malfunctioning or fail for the pairs of electrodes for which at least one electrical parameter of the power signal supplied to the electrodes themselves has an anomalous value; storing an indicator of the pairs of electrodes in the fail condition; and selecting the pairs of electrodes in the fail condition and re-computing new parameters in order to implement a subsequent electroporation process.

Abstract: A medical device, in particular for electroporation treatment, characterized by having: a thimble-like main body fitted, in use, to a hand of an operator; and a member connected to the main body and fitted with needles by which the operator performs the therapeutic treatment.

Abstract: A reversible electroporation device in which an electric pulse generator generates a sequence of electric pulses delivered to electrodes coupled to a tissue in which a process of reversible electroporation that generates cell apoptosis is to be performed. The device is configured to control the amplitude of the pulses and the number of the pulses delivered to the electrodes so that the amount of energy per weight unit (absorbed dose) applied to the tissue is in a range between a first lower limit value of about 3000 J/kg and a second upper limit value of about 4500 J/kg.

Abstract: A medical device, in particular for electroporation treatment, characterized by having: a thimble-like main body fitted, in use, to a hand of an operator; and a member connected to the main body and fitted with needles by which the operator performs the therapeutic treatment.