Abstract: A powered medical fluid injector may have a disposable medical fluid injection manifold that controls fluid routing between the injector and a patient line and also controls fluid flow to a pressure sensor contained within the manifold. In one example, the medical fluid injection manifold includes a manifold housing having at least two inlets for different pressurized medical fluids and at least two corresponding outlets. The medical fluid injection manifold may also have a pressure sensor configured to measure a hemodynamic pressure of a patient. The pressure sensor may be positioned within the manifold housing and in selective fluid communication with the one of the outlet ports of the manifold housing.