Patents by Inventor Matvey E. Lukashev

Matvey E. Lukashev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NRF2 Screening Assays and Related Methods and Compositions
    Publication number: 20200016072
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 16, 2020
    Applicant: Biogen MA Inc.
    Inventor: Matvey E. Lukashev
  • NRF2 Screening Assays and Related Methods and Compositions
    Publication number: 20180263906
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Applicant: Biogen MA Inc.
    Inventors: Matvey E. Lukashev, Gilmore O'Neill
  • NRF2 Screening Assays and Related Methods and Compositions
    Publication number: 20150366803
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: May 21, 2015
    Publication date: December 24, 2015
    Inventors: Matvey E. Lukashev, Gilmore O'Neill
  • NRF2 Screening Assays and Related Methods and Compositions
    Publication number: 20130303613
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 14, 2013
    Inventor: Matvey E. LUKASHEV
  • Treatment for multiple sclerosis
    Patent number: 8399514
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: March 19, 2013
    Assignee: Biogen Idec MA Inc.
    Inventors: Matvey E. Lukashev, Gilmore O'Neill
  • BIOMARKERS AND ASSAYS FOR THE TREATMENT OF CANCER
    Publication number: 20120282245
    Abstract: This invention features methods for prognosticating the efficacy of a cancer treatment comprising administration of a lymphotoxin-? receptor (LT-?-R) using TRAF3, TRAF2, and/or p53 markers, as well as combination therapies that include a composition that activates lymphotoxin-beta receptor signaling in combination with one or more other agents.
    Type: Application
    Filed: October 3, 2007
    Publication date: November 8, 2012
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Matvey E. Lukashev, Pradeep Bista, Weike Zeng
  • Treatment for Amyotrophic Lateral Sclerosis
    Publication number: 20120259012
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: May 7, 2012
    Publication date: October 11, 2012
    Applicant: Biogen Idec MA Inc.
    Inventor: Matvey E. LUKASHEV
  • Treatment for Multiple Sclerosis
    Publication number: 20120196931
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 2, 2012
    Applicant: Biogen Idec MA Inc.
    Inventors: Matvey E. LUKASHEV, Gilmore O'Neill
  • NRF2 SCREENING ASSAYS AND RELATED METHODS AND COMPOSITIONS
    Publication number: 20110112196
    Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.
    Type: Application
    Filed: February 7, 2008
    Publication date: May 12, 2011
    Inventor: Matvey E Lukashev
  • Human stress array
    Publication number: 20020009730
    Abstract: Human stress arrays and methods for their use are provided. The subject arrays include a plurality of polynucleotide spots, each of which is made up of a polynucleotide probe composition of unique polynucleotides corresponding to a human stress gene. The subject arrays find use in hybridization assays, particularly in assays for the identification of differential gene expression of human stress genes.
    Type: Application
    Filed: February 13, 2001
    Publication date: January 24, 2002
    Inventors: Alex Chenchik, Matvey E. Lukashev