Patents by Inventor Matyas Leitold
Matyas Leitold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5254570Abstract: The present invention relates to a pharmaceutical composition comprising: (a) a compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined below; and (b) isosorbide 5-mononitrate or isosorbide 2-mononitrate or glycerol trinitrate or glycerol 1-mononitrate or glycerol 2-mononitrate: and, optionally (c) a pharmaceutically acceptable carrier. The composition is useful in the prevention and treatment of cardiovascular diseases, and is especially useful in the prevention and treatment of angina pectoris and myocardial infarction.Type: GrantFiled: September 20, 1989Date of Patent: October 19, 1993Assignee: Pfizer Inc.Inventors: Peter Stoss, Matyas Leitold
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Patent number: 4891373Abstract: Novel aminopropanol derivatives of 1,4:3,6-dianhydro-hexitol nitrates of the general formula I ##STR1## in which X has the meaning given in the specification, processes for their preparation and their use in preventing and treating angina pectoris, systemic hypertension and pulmonary hypertension in mammals.Type: GrantFiled: November 23, 1988Date of Patent: January 2, 1990Assignee: Pfizer Inc.Inventors: Peter Stoss, Matyas Leitold, Rodney Yeates
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Patent number: 4883796Abstract: Oxime ethers of 2,6-dioxabicyclo[3.3.0]octanones of the formula I ##STR1## have pharmacological activity and are especially applicable as drugs for the prophylaxis and therapy of cardiac and circulatory diseases.Type: GrantFiled: February 2, 1988Date of Patent: November 28, 1989Assignee: Heinrich Mack Nachf.Inventors: Matyas Leitold, Peter Stoss
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Patent number: 4769379Abstract: Dianhydrohexites of the formula ##STR1## wherein R.sup.1 is hydrogen or benzyl, R.sub.2 is alkyl or omega-theophyllin-7-yl-alkyl, and R.sup.1 and R.sub.2 together with the nitrogen atom to which they are attached form a bicyclic group and R.sup.3 is hydrogen, acyl, pyridylcarbonyl, nitro or a hydroxylamino group, are formed by an analogous method and used as pharmaceuticals in the treatment of heart and circulatory diseases.Type: GrantFiled: July 2, 1985Date of Patent: September 6, 1988Assignee: Heinrich Mack Nachf.Inventors: Matyas Leitold, Peter Stoss
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Patent number: 4559351Abstract: The present invention relates to new acyl derivatives of 1,4:3,6-dianhydrohexitols, processes for their preparation and drugs containing the same. The new compounds have a cardiovascular effect and can be used as antihypertensive agents, as peripheral and central vasodilators and as coronary therapeutic agents.Type: GrantFiled: June 26, 1984Date of Patent: December 17, 1985Assignee: Heinrich Mack Nachf.Inventors: Peter Stoss, Matyas Leitold
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Patent number: 4292319Abstract: Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.Type: GrantFiled: July 14, 1980Date of Patent: September 29, 1981Assignee: Boehringer Ingelheim GmbHInventors: Oswald Tauber, Gunther Engelhardt, Matyas Leitold, Gunther Schmidt
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Patent number: 4256747Abstract: Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.Type: GrantFiled: March 30, 1979Date of Patent: March 17, 1981Assignee: Boehringer Ingelheim GmbHInventors: Oswald Tauber, Gunther Engelhardt, Matyas Leitold, Gunther Schmidt
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Patent number: 4213984Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 3 to 12 carbon atoms; unsaturated aliphatic hydrocarbyl of 3 to 20 carbon atoms comprising 1 to 3 double bonds and/or one triple bond; phenyl(alkyl of 2 to 4 carbon atoms); methylenedioxybenzyl; chlorobenzyl; indan-5-ylmethyl; indan-3-ylmethyl; phenyl(alkenyl of 2 to 4 carbon atoms); cycloalkyl of 5 to 7 carbon atoms; (cycloalkyl of 3 to 10 carbon atoms)methyl; (methylcycloalkyl of 4 to 11 carbon atoms)methyl; morpholino(alkyl of 2 to 3 carbon atoms); pyrrolidino(alkyl of 2 to 3 carbon atoms); piperidino (alkyl of 2 to 3 carbon atoms); 4-methylpiperazino(alkyl of 2 to 3 carbon atoms); or, when R.sub.3 and/or R.sub.4 are methyl or ethyl, also methyl or ethyl;R.sub.2 is hydrogen, methyl or ethyl; andR.sub.3 and R.sub.4 are each hydrogen, methyl or ethyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as anti-ulcerogenics and secretion inhibitors.Type: GrantFiled: May 19, 1978Date of Patent: July 22, 1980Assignee: Boehringer Ingelheim GmbHInventors: Gunther Schmidt, Matyas Leitold
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Patent number: 4213985Abstract: Novel 5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-ones of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, straight and branched chain, mono and poly unsaturated aliphatic hydrocarbon of 3 to 20 carbon atoms, phenyl alkyl of 1 to 4 alkyl carbon atoms and cinnamyl, R.sub.2 is selected from the group consisting of hydrogen, methyl and ethyl and A is straight or branched chain alkylene of 2 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having ulcer inhibiting and secretion inhibiting activity and a novel process for their preparation.Type: GrantFiled: May 19, 1978Date of Patent: July 22, 1980Assignee: Boehringer Ingelheim GmbHInventors: Gunther Schmidt, Matyas Leitold
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Patent number: 4210648Abstract: Compounds of the formula ##STR1## wherein A is alkylene of 1 to 5 carbon atoms;R.sub.1 is amino, tert.butylamino, N-cyclohexyl-N-methyl-amino, dibenzylamino, benzylamino, trimethoxybenzyl-amino, 1-ethyl-2-pyrrolidinylmethylamino, 1-ethyl-3-piperidinyl-amino, 9-methyl-3,9-diazabicyclo[3.3.1]nonan-3-yl, 1,2,5,6-tetra-hydro-1-pyridyl, 4-benzyl-piperidino, 1,2,3,6,7,8,9,9a-octahydro-4H-pyrazino[1,2-a]-pyrimidine-1(or-8)yl, 3- or 4-hydroxypiperidino, 3-or 4-methoxypiperidino, 1,2,3,4-tetrahydro-2-isoquinolyl, 3-azaspiro[5.5]undecan-3-yl, 4-oxo-piperidino or the ethyleneketal thereof, hexahydro-3-methyl-1-pyrimidinyl, thiomorpholino, 1-oxido-thiomorpholino, hexahydro-4-methyl-1H-1,4-diazepin-1-yl, 2,6-dimethyl-morpholino,1,4-diazabicyclo [4.3.Type: GrantFiled: May 19, 1978Date of Patent: July 1, 1980Assignee: Boehringer Ingelheim GmbHInventors: Gunther Schmidt, Matyas Leitold
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Patent number: 4154833Abstract: Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic acid addition salt thereof, and a method of using the same as antiphlogistics; the pyridobenzodiazepinone ingredient effectively suppresses the gastro-intestinal side-effects of the anti-inflammatory ingredient.Type: GrantFiled: February 17, 1978Date of Patent: May 15, 1979Assignee: Boehringer Ingelheim GmbHInventors: Oswald Tauber, Gunther Engelhardt, Matyas Leitold, Gunther Schmidt
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Patent number: 4113777Abstract: Compounds of the formula ##STR1## wherein X and R.sub.1 are each chlorine or bromine;R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; andR.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or antiatelectasis factor of the alveoli.Type: GrantFiled: July 1, 1977Date of Patent: September 12, 1978Assignee: Boehringer Ingelheim GmbHInventors: Johannes Keck, Sigfrid Puschmann, Gerd Kruger, Klaus-Reinhold Noll, Matyas Leitold, Helmut Pieper
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Patent number: 4073942Abstract: Compounds of the formula ##STR1## wherein X is chlorine or bromine;R.sub.1 is hydrogen, chlorine or bromine;R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; andR.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or anti-atelectasis factor of the alveoli.Type: GrantFiled: November 25, 1975Date of Patent: February 14, 1978Assignee: Boehringer Ingelheim GmbHInventors: Johannes Keck, Sigfrid Puschmann, Gerd Kruger, Klaus-Reinhold Noll, Matyas Leitold, Helmut Pieper
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Patent number: 4042711Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,A is --CO--NH-- or --NH--CO--, andn is 1, 2 or 3,And non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.Type: GrantFiled: November 11, 1976Date of Patent: August 16, 1977Assignee: Boehringer Ingelheim GmbHInventors: Gerhart Griss, Wolfgang Grell, Rudolf Hurnaus, Robert Sauter, Bernhard Eisele, Nikolaus Kaubisch, Matyas Leitold
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Patent number: 4010279Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.3 is hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl or 4 to 8 carbon atoms,A is --CO--NH-- or --NH--CO--, andn is 1, 2 or 3,And, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.Type: GrantFiled: December 23, 1975Date of Patent: March 1, 1977Assignee: Boehringer Ingelheim GmbHInventors: Gerhart Griss, Wolfgang Grell, Rudolf Hurnaus, Robert Sauter, Bernhard Eisele, Nikolaus Kaubisch, Matyas Leitold
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Patent number: 3993778Abstract: Pharmaceutical compositions containing as an active ingredient an N-(hydroxy-cyclohexyl)-benzylamine of the formula ##SPC1##Wherein R.sub.1 is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as anti-ulcerogenics.Type: GrantFiled: March 25, 1975Date of Patent: November 23, 1976Assignee: Boehringer Ingelheim GmbHInventors: Johannes Keck, Matyas Leitold, Sigfrid Puschmann, Gerd Kruger