Patents by Inventor Mau-Jung Kuo

Mau-Jung Kuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of angiogenic factor by cell culture
    Patent number: 4268629
    Abstract: Process for the production of human angiogenic factor in vitro comprising growing the human diploid cell line IMR-90 on support surface in nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate angiogenic factor and recovering the resulting angiogenic factor from the cells or cell product.
    Type: Grant
    Filed: March 3, 1980
    Date of Patent: May 19, 1981
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Mau-Jung Kuo, Joseph Feder
  • Method of culturing microcarrier supported cells
    Patent number: 4266032
    Abstract: A method of submerged cell culture is provided which employs a microcarrier support comprising cross-linked polystyrene resin beads derivatized with amino acids, peptides, or hydroxy carboxylic acids.
    Type: Grant
    Filed: August 10, 1979
    Date of Patent: May 5, 1981
    Assignee: Monsanto Company
    Inventors: Robert E. Miller, Mau-Jung Kuo, Charles Lewis, Jr.
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4229531
    Abstract: Process for the production of human TAF in vitro comprising growing the human colon adenocarcinoma cell line HT-29 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: October 21, 1980
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4225670
    Abstract: Process for the production of human TAF in vitro comprising growing the human Burkitt lymphoma cell line Raji in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: September 30, 1980
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4217412
    Abstract: Process for the production of human TAF in vitro comprising growing the human medulloblastoma cell line TE-671 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: April 25, 1979
    Date of Patent: August 12, 1980
    Assignee: President and Fellows of Harvard College
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo, Moses J. Folkman
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4210718
    Abstract: Process for the production of human TAF in vitro comprising growing the human melanoma cell line A-375 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: July 1, 1980
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4210719
    Abstract: Process for the production of human TAF in vitro comprising growing the human rhabdomyosarcoma cell line RD in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: July 1, 1980
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo
  • Production of tumor angiogenesis factor by cell culture
    Patent number: 4209587
    Abstract: Process for the production of human TAF in vitro comprising growing the human liver adenocardinoma cell line SK-HEP-1 in agitated, liquid suspension of nutrient culture medium at about 35.degree.-38.degree. C. for a sufficient time to elaborate TAF and recovering the resulting TAF from the cells or cell product.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: June 24, 1980
    Assignee: Monsanto Company
    Inventors: William R. Tolbert, Joseph Feder, Mau-Jung Kuo
  • Production of urokinase
    Patent number: 4190708
    Abstract: The yield of urokinase produced by cell culture of kidney cells is improved by incorporating in the cell culture medium an elevated level of phenylalanine.
    Type: Grant
    Filed: May 24, 1978
    Date of Patent: February 26, 1980
    Assignee: Monsanto Company
    Inventors: Mau-Jung Kuo, Margaret J. Reents, Joseph Feder
  • Mammalion cell culture process
    Patent number: 4087327
    Abstract: A cell culture reactor system is provided for the growth of cells in vitro which employs elongate hollow or solid fibers arranged in a shallow layer configuration as a matrix for cell attachment in which the flow path of the culture media is directed substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: May 2, 1978
    Assignee: Monsanto Company
    Inventors: Joseph Feder, Katharine Ku, Mau-Jung Kuo