Abstract: Well assemblies and related systems and methods are disclosed. In accordance with an implementation, an apparatus includes a body having a first wall, a second wall, a cover, and an impermeable barrier. The first wall defines a well having a port and a distal end defining an opening having an opening perimeter. The second wall surrounds the first wall and has a distal end. The cover is coupled to the distal end of the first wall and covers the opening along the opening perimeter at a connected portion and uncoupled from the distal end of the first wall along the opening perimeter at an unconnected portion. The impermeable barrier is coupled to the distal end of the second wall and covers the well. The unconnected portion forms a vent that allows air flow out of the well.

Abstract: The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.

Abstract: The present disclosure relates to a system, method, and computer program for providing a pricing platform for performing pricing calculations for a plurality of different customers with different types of pricing calculations. An instance of the price-calculation pipeline is created for each of a plurality of customers of the pricing platform. The instances of the price-calculation pipeline are executed to perform pricing calculations for a plurality of different customers with different types of pricing calculations. For each instance of the price-calculation pipeline, a performance metric is generated for each of the modular pricing stages within the instance. The performance metrics are displayed in a user dashboard that provides user controls that enable the user to adjust the computational resources allocated to each of the modular pricing stages executing on the platform. The computational resources allocated to one or more modular pricing stages are adjusted in accordance with received user input.

Abstract: Non-contact dispenser assemblies and related systems and methods are disclosed. An implementation of an apparatus is disclosed that includes a reagent cartridge including a body defining a plurality of reservoirs. Each reservoir has an outlet and a distal end defining an opening, a manifold assembly including an outlet, a common fluidic line fluidly coupled to the outlet, a plurality of reagent fluidic lines coupled to the corresponding outlet of the reservoirs, and a plurality of membrane valves selectively fluidly coupling the common fluidic line and a corresponding one of the plurality of reagent fluidic lines.

Abstract: In some examples, an instrument for measuring a volume of a liquid is provided. A gas flow rate sensor may measure a rate of flow of a pressurized gas to a reservoir storing a liquid. A controller may be coupled to the gas flow rate sensor and may calculate a volume of the liquid that the flow of pressurized gas displaces from the reservoir. In some examples, a method of measuring a volume of a liquid is provided. Using a gas flow rate sensor, a flow of pressurized gas may be measured. The flow of the pressurized gas may be delivered to a reservoir storing a liquid. A volume of the liquid in the reservoir may be displaced using the flow of pressurized gas. The measurement of the flow of the pressurized gas may be used to calculate the volume of the liquid that is displaced.

Abstract: A microphone assembly includes a housing including a base, a cover, and a sound port. The microphone assembly further includes an acoustic transducer and an electrical circuit, both of which are disposed in an enclosed volume of the housing. The transducer and electrical circuit work in concert to convert sound waves into a processed digital audio signal. The electrical circuit is configured to process digital data in a series of frames that correspond to a fixed period in time. The electrical circuit is further configured to reduce noise in the resulting signal by varying the current draw required in a randomized or pseudo-randomized fashion between adjacent frames of digital data.

Abstract: An example path discovery system includes a memory and processing circuitry in communication with the memory. The processing circuitry is configured to obtain routing script metadata associated with a telephony network, to parse routing logic implemented by one or more nodes of the telephony network, to emulate, using the routing script metadata and the parsed routing logic, a traversal path for a call through the telephony network, the emulated traversal path including the one more nodes for which the routing logic is parsed, to store, to the memory, the emulated traversal path and respective final states of runtime variables associated with the one or more nodes included in the emulated traversal path, and to generate, in a machine-readable format, one or more reports indicating a destination of the emulated traversal path in the telephony network and an ingress of the emulated traversal path with respect to the telephony network.

Abstract: A microphone assembly includes a housing including a base, a cover, and a sound port. The microphone assembly further includes an acoustic transducer and an electrical circuit, both of which are disposed in an enclosed volume of the housing. The transducer and electrical circuit work in concert to convert sound waves into a processed digital audio signal. The electrical circuit is configured to process digital data in a series of frames that correspond to a fixed period in time. The electrical circuit is further configured to reduce noise in the resulting signal by varying the current draw required in a randomized or pseudo-randomized fashion between adjacent frames of digital data.

Abstract: The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.

Abstract: An example path discovery system includes a memory and processing circuitry in communication with the memory. The processing circuitry is configured to obtain routing script metadata associated with a telephony network, to parse routing logic implemented by one or more nodes of the telephony network, to emulate, using the routing script metadata and the parsed routing logic, a traversal path for a call through the telephony network, the emulated traversal path including the one more nodes for which the routing logic is parsed, to store, to the memory, the emulated traversal path and respective final states of runtime variables associated with the one or more nodes included in the emulated traversal path, and to generate, in a machine-readable format, one or more reports indicating a destination of the emulated traversal path in the telephony network and an ingress of the emulated traversal path with respect to the telephony network.

Abstract: A multi-relay including a first relay switch operable over a first current range; a second relay switch operable over a second current range; and a current sensor configured to: detect an input current; in response to the input current being within the first current range, activate the first relay switch; and in response to the input current being within the second current range, activate the second relay switch.

Abstract: The present invention, among other things, provides compounds and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.

Abstract: If there are mirrored WAN optimization devices, a master WAN optimization device sends a datagram received from a source across the WAN and sends a copy of the datagram to a mirroring WAN optimization device. When the mirroring WAN optimization device ACKs the mirrored datagram, the master WAN optimization device ACKs the host. When the master WAN optimization device receives the ACK from the WAN, the ACK is forwarded to the mirroring WAN optimization device, which deletes the mirrored datagram. Alternatively, the mirroring WAN optimization device can receive the datagram from the source, store it and forward it to the master WAN optimization device, which sends the datagram across the WAN and sends an ACK to the host. When the ACK from the WAN is received, the master WAN optimization device forwards the ACK to the mirroring WAN optimization device, when then deletes the mirrored datagram.

Abstract: The present invention, among other things, provides compounds and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Abstract: The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.

Abstract: The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.

Abstract: The present invention provides adiabatic plug flow reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors comprise one or more designs that minimize the production of by-products at a desired conversion.

Abstract: The present invention, among other things, provides compounds and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound.

Abstract: A multi-relay including a first relay switch operable over a first current range; a second relay switch operable over a second current range; and a current sensor configured to: detect an input current; in response to the input current being within the first current range, activate the first relay switch; and in response to the input current being within the second current range, activate the second relay switch.