Patents by Inventor Maura Barbisin

Maura Barbisin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9481909
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: November 1, 2016
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Jaiprakash Shewale, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Publication number: 20150361493
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 17, 2015
    Inventors: Jaiprakash SHEWALE, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Patent number: 8445657
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: May 21, 2013
    Assignee: Applied Biosystems, LLC
    Inventors: Jaiprakash Shewale, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Publication number: 20130017248
    Abstract: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme stubstrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.
    Type: Application
    Filed: May 10, 2012
    Publication date: January 17, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Ronald Graham, Maura Barbisin
  • Publication number: 20120015370
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Application
    Filed: August 26, 2011
    Publication date: January 19, 2012
    Applicant: Applied Biosystems, LLC
    Inventors: Jaiprakash G. SHEWALE, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Patent number: 8012691
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: September 6, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Jaiprakash G. Shewale, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Publication number: 20100022001
    Abstract: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme substrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.
    Type: Application
    Filed: May 26, 2009
    Publication date: January 28, 2010
    Applicant: Applied Biosystems, LLC
    Inventors: Ronald Graham, Maura Barbisin
  • Publication number: 20080268448
    Abstract: The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of human nuclear and male DNA present in a biological sample. Such sample characterization is useful for achieving efficient and accurate results in downstream molecular techniques such as genotyping.
    Type: Application
    Filed: February 20, 2008
    Publication date: October 30, 2008
    Applicant: Applera Corporation
    Inventors: Jaiprakash G. Shewale, Manohar Furtado, Pius Brzoska, Maura Barbisin, Rixun Fang, Michael Malicdem, Cristin O'Shea
  • Publication number: 20060159738
    Abstract: Highly efficient cationic liposomes are provided as a system for the delivery to cells of agents or compounds, such as, compounds capable of silencing a target protein and enzyme stubstrates. The cationic liposomes can be used in methods of detecting the inhibition activity or apparent activity of a target protein in a cell, and methods of identifying a protein associated with a pathway, such as, a signal transduction pathway in a cell.
    Type: Application
    Filed: December 14, 2005
    Publication date: July 20, 2006
    Applicant: Applera Corporation
    Inventors: Ronald Graham, Maura Barbisin
  • Publication number: 20050244907
    Abstract: In one aspect, the present disclosure relates to methods for detecting an activity of an enzyme in a cell. In some embodiments, the methods include contacting a cell with a liposome containing at least one substrate thereby facilitating introduction of the substrate into the cell. The substrate is capable of producing a detectable light signal when acted on by the enzyme, and the signal is detected. The methods can be used in screening agents that can inhibit or activate an enzyme activity. The methods can also be used in various downstream assays such the detection of interactions between intracellular proteins, screening for variants of an enzyme, and detection of various diseases. Compositions and kits for carrying out the various methods are also provided.
    Type: Application
    Filed: December 15, 2004
    Publication date: November 3, 2005
    Inventors: Ronald Graham, Michael Sekar, Maura Barbisin