Patents by Inventor Maura G. Donovan
Maura G. Donovan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040039417Abstract: This invention is an electrical stimulation apparatus for delivering an electrical field or electrical current over a predetermined period of time to a vascular tissue (150) in order to stimulate a cell initiated thrombolytic peptide response in cells within the vascular tissue. The electrical stimulation apparatus includes an electrical field or electrical current generating unit including a power support, a control mechanism interconnected with the power supply, and a plurality of electrodes designed to generate an electrical field or electrical current proximal to, or within to the vascular tissue. The amplitude of the electrical field or electrical current delivered to or generated proximal to, or within the vascular tissue, and the duration of the period of delivery are sufficient to stimulate production of thrombolytic peptides in the vascular tissue.Type: ApplicationFiled: April 15, 2003Publication date: February 26, 2004Applicant: Medtronic, Inc.Inventors: Orhan Soykan, Maura G. Donovan, Curtis D. Deno, Terrell M. Williams, Paul V. Trescony, Timothy H. Robinson
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Patent number: 6671558Abstract: An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated and/or differentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium or otherwise damaged or diseased myocardial tissue.Type: GrantFiled: November 3, 2000Date of Patent: December 30, 2003Assignee: Medtronic, Inc.Inventors: Orhan Soykan, Maura G. Donovan
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Publication number: 20030204206Abstract: The present invention provides methods and systems for regulating delivery of therapeutic proteins and nucleic acids.Type: ApplicationFiled: December 20, 2001Publication date: October 30, 2003Applicant: Medtronic, Inc.Inventors: Rodolfo A. Padua, Carl A. Schu, Matthew D. Bonner, Maura G. Donovan, Orhan Soykan
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Publication number: 20020138123Abstract: A medical electrical lead or indwelling catheter comprising an elongated body having a tissue-contacting surface that includes a polymer in intimate contact with a steroidal anti-inflammatory agent.Type: ApplicationFiled: November 28, 2001Publication date: September 26, 2002Applicant: Medtronic, Inc.Inventors: Jesus W. Casas-Bejar, Darrel F. Untereker, Maura G. Donovan, Zhao Qinghong, Brian C.A. Fernandes, Timothy H. Robinson, Peter T. Schroeder
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Publication number: 20020010492Abstract: The present invention provides a novel stimulatory device for the controlled production of angiogenic growth factors. More specifically, the present invention provides a subthreshold pulse generator for the local production of vascular endothelial growth factor.Type: ApplicationFiled: March 5, 2001Publication date: January 24, 2002Applicant: Medtronic, Inc.Inventors: Maura G. Donovan, Orhan Soykan, D. Curtis Deno, Lawrence J. Mulligan, Brian C. A. Fernandes
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Patent number: 6238429Abstract: A length of living conductive cells may be injected directly or may be grown to be attached to a fibrous matrix of material that provides for flexible structure so as to deliver a stimulation signal from one end of the biologic cable to the other to induce a physiologic reaction in body tissue.Type: GrantFiled: May 5, 1998Date of Patent: May 29, 2001Assignee: Medtronic, Inc.Inventors: H. Toby Markowitz, Maura G. Donovan, Khawar Mehdi
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Patent number: 6228845Abstract: This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.Type: GrantFiled: October 21, 1998Date of Patent: May 8, 2001Assignee: Medtronic, Inc.Inventors: Maura G. Donovan, Paul M. Stein
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Publication number: 20010000802Abstract: An implantable system that includes a carrier and eukaryotic cells, which produce and release a therapeutic agent, and a stimulating element for stimulating the release of the therapeutic agent. The system can also include a sensing element for monitoring a physiological condition and triggering the stimulating element to stimulate the delivery device to release the therapeutic agent. Alternatively, the patient in which the system is implanted can activate the stimulating element to release the therapeutic agent.Type: ApplicationFiled: December 20, 2000Publication date: May 3, 2001Applicant: Medtronic, Inc.Inventors: Orhan Soykan, Maura G. Donovan
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Patent number: 6206914Abstract: An implantable system that includes a carrier and eukaryotic cells, which produce and release a therapeutic agent, and a stimulating element for stimulating the release of the therapeutic agent. The system can also include a sensing element for monitoring a physiological condition and triggering the stimulating element to stimulate the delivery device to release the therapeutic agent. Alternatively, the patient in which the system is implanted can activate the stimulating element to release the therapeutic agent.Type: GrantFiled: August 31, 1998Date of Patent: March 27, 2001Assignee: Medtronic, Inc.Inventors: Orhan Soykan, Maura G. Donovan
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Patent number: 6151525Abstract: An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near an infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium.Type: GrantFiled: September 2, 1998Date of Patent: November 21, 2000Assignee: Medtronic, Inc.Inventors: Orhan Soykan, Maura G. Donovan
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Patent number: 5897590Abstract: A dissection glove for forming in a patient a tissue pocket to receive an implantable device. The dissection glove is constructed of an absorbent material formed into at least one recess with an open end for receiving a portion of a surgeon's gloved hand. A retaining mechanism is provided for releasably retaining the dissection glove to a portion of the surgeon's gloved hand. An extraction mechanism is optionally provided for extracting the dissection glove from the tissue pocket. The dissection glove may be constructed from a variety of materials, such as polypropylene nonwoven mesh or calcium alginate gauze. The present invention is also directed to a method of forming a tissue pocket in a patient for receiving an implantable device using the present dissection glove.Type: GrantFiled: November 25, 1997Date of Patent: April 27, 1999Assignee: Medtronic, Inc.Inventor: Maura G. Donovan
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Patent number: 5848987Abstract: A catheter having a microtextured exterior surface portion is employed to deliver fluids such as medicaments internally to the parenchyma of an organ or other internal living bodily tissue. The microtextured exterior surface portion promotes cellular tissue ingrowth into the textured surface, thereby creating an effective fluid seal in the bore formed in the tissue and inhibiting the body's rejection response to the catheter. The fluid seal prevents the reflux of infused fluid from the distal end of the catheter from the bore opening and permits controlled delivery of fluid to affected tissue.Type: GrantFiled: April 30, 1996Date of Patent: December 15, 1998Assignee: Medtronic, Inc.Inventors: Michael D. Baudino, Mark T. Rise, Maura G. Donovan
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Patent number: 5833651Abstract: This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.Type: GrantFiled: November 8, 1996Date of Patent: November 10, 1998Assignee: Medtronic, Inc.Inventors: Maura G. Donovan, Paul M. Stein
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Patent number: 5766248Abstract: A dissection glove for forming in a patient a tissue pocket to receive an implantable device. The dissection glove is constructed of an absorbent material formed into at least one recess with an open end for receiving a portion of a surgeon's gloved hand. A retaining mechanism is provided for releasably retaining the dissection glove to a portion of the surgeon's gloved hand. An extraction mechanism is optionally provided for extracting the dissection glove from the tissue pocket. The dissection glove may be constructed from a variety of materials, such as polypropylene nonwoven mesh or calcium alginate gauze. The present invention is also directed to a method of forming a tissue pocket in a patient for receiving an implantable device using the present dissection glove.Type: GrantFiled: April 25, 1996Date of Patent: June 16, 1998Assignee: Medtronic, Inc.Inventor: Maura G. Donovan
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Patent number: 5695777Abstract: A wound dressing for use with exuding wounds includes (a) an outer vapor permeable layer permitting transpiration of fluid from the dressing; (b) an intermediate layer of hydrogel adapted for absorbing wound exudate; (c) a wound-contacting layer for separating the intermediate hydrogel layer from the wound; (d) wicking means associated with the wound-contacting layer for conducting exudate from the wound to the hydrogel; and (e) a therapeutic agent retained in the dressing by the wound-contacting layer.Type: GrantFiled: May 10, 1994Date of Patent: December 9, 1997Assignee: Medtronic, Inc.Inventors: Maura G. Donovan, James R. Keogh, Carolann M. Holmblad
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Patent number: 5356372Abstract: An occlusive, pressure-reducing wound dressing with a multi-layer laminate construction providing one easy-to-apply dressing. The occlusive pressure-reducing dressing includes an occlusive, wound-contacting layer made of a biologically compatible polymer. A pressure-reducing layer is joined at a bottom surface to the occlusive layer. The pressure-reducing layer is comprised of a soft, air-containing material such as a foam or an air-entrapping film which has a top surface shaped to provide a progressive rate of resistance to compressive force applied to the pressure-reducing layer and which allows the pressure-reducing layer to conform to curved body surfaces. The occlusive portion of the dressing therefore provides a moist environment and a barrier against infection while the pressure-reducing portion or component minimizes interaction between the wound and any supporing surface in contact therewith.Type: GrantFiled: December 1, 1993Date of Patent: October 18, 1994Assignee: Ludlow CorporationInventors: Maura G. Donovan, Matthew A. Bergan