Patents by Inventor Maura McGrail

Maura McGrail has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATERIALS AND METHODS FOR EFFICIENT TARGETED KNOCK IN OR GENE REPLACEMENT
    Publication number: 20200208146
    Abstract: Materials and methods for generating targeted knock ins and gene replacements with high precision and efficiency are provided herein.
    Type: Application
    Filed: July 12, 2018
    Publication date: July 2, 2020
    Inventors: Karl J. Clark, Stephen C. Ekker, Jeffrey Essner, Jordan Michael Welker, Maira Pedroso de Almeida, Wesley Allen Wierson, Maura McGrail
  • DIABETES GENE
    Publication number: 20080261231
    Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 23, 2008
    Applicant: MYRIAD GENETICS, INCORPORATED
    Inventors: Maura McGrail, Deanna L. Russell, Donna M. Shattuck
  • Diabetes gene
    Patent number: 7374884
    Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: May 20, 2008
    Assignee: Myriad Genetics, Inc.
    Inventors: Maura McGrail, Deanna L. Russell, Donna M. Shattuck
  • Diabetes gene
    Patent number: 6902888
    Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to gernline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: June 7, 2005
    Assignee: Myriad Genetics, Inc.
    Inventors: Maura McGrail, Deanna L. Russell, Donna M. Shattuck
  • Diabetes gene
    Publication number: 20040265882
    Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM) . More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes.
    Type: Application
    Filed: May 13, 2004
    Publication date: December 30, 2004
    Applicant: Myriad Genetics, Incorporated
    Inventors: Maura McGrail, Deanna L. Russell, Donna M. Shattuck