Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).

Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: A wrap type infant carrier which also integrates certain attributes of mei tai and SSC carriers to provide an optimal meld of some of the most desirable attributes of these existing carriers, the present carrier thus providing the comfort and closeness of a wrap carrier, but further being configured to be easily fitted to the wearer, thus avoiding any excessive learning curve associated with its use. In addition to being easy to use, the present carrier is also configured to more effectively distribute the load to the caregiver to mitigate muscle strain or fatigue.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with various modalities, including a selectively expandable and retractable seat portion and a selectively deployable sling seat, as allows for varying degrees of adjustability to the effective width of and support level provided by the seat portion of the carrier alone or in combination with the seat sling thereof.

Abstract: An adjustable infant carrier which is outfitted with various modalities, including a selectively expandable and retractable seat portion and a selectively deployable sling seat, as allows for varying degrees of adjustability to the effective width of and support level provided by the seat portion of the carrier alone or in combination with the seat sling thereof.

Abstract: A wrap type infant carrier which also integrates certain attributes of mei tai and SSC carriers to provide an optimal meld of some of the most desirable attributes of these existing carriers, the present carrier thus providing the comfort and closeness of a wrap carrier, but further being configured to be easily fitted to the wearer, thus avoiding any excessive learning curve associated with its use. In addition to being easy to use, the present carrier is also configured to more effectively distribute the load to the caregiver to mitigate muscle strain or fatigue.

Abstract: An infant carrier which provides the comfort of a wrap-type carrier and the ease of use of a conventional soft-sided infant carrier. The infant carrier includes a pair of adjustable side panels which allow a wearer to selectively transition the side panels between narrow and wide seat configurations to accommodate the size of the infant seated within the carrier. The carrier also includes a torso band, which enables adjustment of the infant support panel relative to the wearer, and also rests higher than conventional waist belts commonly employed on most soft-sided infant carriers.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.

Abstract: An adjustable infant carrier includes a waist belt disposable about the waist of the wearer. A pair of shoulder straps is coupled to the waist belt, wherein each shoulder strap includes a free end portion and an opposed proximal end portion coupled to the waist belt. A carrier body is coupled to the waist belt and is connectable to the shoulder straps. The carrier body includes a middle section and a pair of conversion flaps disposed on opposed sides of the middle section. Each conversion flap is selectively transitional between a narrow configuration, wherein a free end portion of the conversion flap is connected to the middle section, and a wide configuration, wherein the free end portion of the conversion flap is connected to the waist belt.

Abstract: An infant carrier which provides the comfort of a wrap-type carrier and the ease of use of a conventional soft-sided infant carrier. The infant carrier includes a pair of adjustable side panels which allow a wearer to selectively transition the side panels between narrow and wide seat configurations to accommodate the size of the infant seated within the carrier. The carrier also includes a torso band, which enables adjustment of the infant support panel relative to the wearer, and also rests higher than conventional waist belts commonly employed on most soft-sided infant carriers.

Abstract: An adjustable infant carrier includes a waist belt disposable about the waist of the wearer. A pair of shoulder straps is coupled to the waist belt, wherein each shoulder strap includes a free end portion and an opposed proximal end portion coupled to the waist belt. A carrier body is coupled to the waist belt and is connectable to the shoulder straps. The carrier body includes a middle section and a pair of conversion flaps disposed on opposed sides of the middle section. Each conversion flap is selectively transitional between a narrow configuration, wherein a free end portion of the conversion flap is connected to the middle section, and a wide configuration, wherein the free end portion of the conversion flap is connected to the waist belt.

Abstract: Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.

Abstract: Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin.

Abstract: Cancer marker sets consisting of particular genes differentially expressed in tumours provide improved accuracy of predicting effectiveness of paclitaxel or paclitaxel-like drug treatment against a cancer. These sets are further useful for screening drug candidates for paclitaxel-like cancer treatment activity. The cancer marker sets may be used in a clinical setting to provide information about the likelihood that a cancer patient would or would not respond to paclitaxel or paclitaxel-like drug treatment.

Abstract: Systems, components and methods for expressing breast milk are described herein. An adapter includes a first connector portion, a second connector portion and a transition portion extending between the first connector portion and the second connector portion. At least the first connector portion and the transition portion cooperate to define an interior chamber configured to receive fluid. The first connector portion is configured for connection to a pump assembly, and the second connector portion is configured for connection, via a plurality of internal threads, to a spout of a fluid container.