Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).

Abstract: A method and system for deselecting biological solids in an influent containing water. The method and system include supplying an influent to an inlet of a reactor comprising at least one of a bioreactor, an internal deselector, a particle deselector, and one or more return lines; dispersing the influent in the bioreactor to form a solid-liquid mixture containing biological solids; retaining, retarding, or providing a differential of, by the internal deselector, biological solids from the solid-liquid mixture to form a deselected solid-liquid mixture and returnable biological solids; feeding said deselected solid-liquid mixture to the particle deselector; deselecting, by the particle deselector, remainder biological solids from the deselected solid-liquid mixture; and supplying, by the one or more return lines, the returnable biological solids to the bioreactor.

Abstract: This disclosure relates to physical selection, deselection or outselection for smaller, less dense, sheared or compressed particles in sludge, wherein the first deselection step occurs at the reactor or at a clarification step, by separately deselecting for such particles and then a second deselection step occurs in an external selector. This double deselection promotes the more efficient removal of slow settling particles, while simultaneously allowing for maintenance of multiple solids residence times for fast and slow growing organisms. The deselection in a clarifier occurs typically at the periphery of the tank or at the surface of a blanket using a positive or negative pressure device. Structures such as slotted or perforated plates, pipes or manifolds can be used to assist in such deselection. Baffles can also be used for such deselection.

Abstract: A modified ternary Zr—Ta—Y oxide system is provided having a larger non-transformable, tetragonal phase that enables thermal barrier materials with improved properties of low thermal conductivity, higher sinter resistance, higher phase stability, and higher toughness to be created.

Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).

Abstract: There are provided tetravalent TGF? receptor-ectodomain based traps having a tailored isoform-specificity profile for neutralization of TGF? ligands, and methods of use thereof in the treatment of diseases and conditions associated with TGF?, particularly TGF?1 and TGF?3. In particular, there are provided TGF? binding agents designed to tailor TGF? isoform specificity, in order to maximize therapeutic efficacy in specific disease indications while minimizing adverse effects. The TGF? binding agents comprise two polypeptides assembled via a multimerization domain, each polypeptide having two TGF?II receptor (TGF?R) ligand-binding domains linked as a doublet, wherein the linkers are selected to tailor isoform specificity.

Abstract: There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGF? superfamily ligand signaling, such as pulmonary hypertension, fibrosis, muscle weakness and atrophy, metabolic disorders and/or cardiometabolic disease, bone damage, and/or low red blood cell levels (such as anemia).

Abstract: This disclosure relates to physical selection, deselection or outselection for smaller, less dense, sheared or compressed particles in sludge, wherein the first deselection step occurs at the reactor or at a clarification step, by separately deselecting for such particles and then a second deselection step occurs in an external selector. This double deselection promotes the more efficient removal of slow settling particles, while simultaneously allowing for maintenance of multiple solids residence times for fast and slow growing organisms. The deselection in a clarifier occurs typically at the periphery of the tank or at the surface of a blanket using a positive or negative pressure device. Structures such as slotted or perforated plates, pipes or manifolds can be used to assist in such deselection. Baffles can also be used for such deselection.

Abstract: Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

Abstract: Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

Abstract: Provided are systems, methods, and kits for multifunctional smell assessment. The kits may comprise a first surface adhered by a first releasable adhesive comprising an odorous volatile compound; and the system for registering if the odorous volatile compound is detected by a user. The system or method may comprise queries for obtaining a first input on whether the user detects and identifies the odorous volatile compound, and an intensity by which the odor is perceived.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: A wrap type infant carrier which also integrates certain attributes of mei tai and SSC carriers to provide an optimal meld of some of the most desirable attributes of these existing carriers, the present carrier thus providing the comfort and closeness of a wrap carrier, but further being configured to be easily fitted to the wearer, thus avoiding any excessive learning curve associated with its use. In addition to being easy to use, the present carrier is also configured to more effectively distribute the load to the caregiver to mitigate muscle strain or fatigue.

Abstract: An adjustable infant carrier which is outfitted with conversion flaps adapted to allow for selective adjustability to the effective width of the seat portion of the carrier so as to accommodate children of differing size, as well as different support positions/configurations.

Abstract: An adjustable infant carrier which is outfitted with various modalities, including a selectively expandable and retractable seat portion and a selectively deployable sling seat, as allows for varying degrees of adjustability to the effective width of and support level provided by the seat portion of the carrier alone or in combination with the seat sling thereof.

Abstract: An adjustable infant carrier which is outfitted with various modalities, including a selectively expandable and retractable seat portion and a selectively deployable sling seat, as allows for varying degrees of adjustability to the effective width of and support level provided by the seat portion of the carrier alone or in combination with the seat sling thereof.

Abstract: A wrap type infant carrier which also integrates certain attributes of mei tai and SSC carriers to provide an optimal meld of some of the most desirable attributes of these existing carriers, the present carrier thus providing the comfort and closeness of a wrap carrier, but further being configured to be easily fitted to the wearer, thus avoiding any excessive learning curve associated with its use. In addition to being easy to use, the present carrier is also configured to more effectively distribute the load to the caregiver to mitigate muscle strain or fatigue.

Abstract: A biodegradable and disposable shoe liner is made of a first layer impregnated with a deodorant and an absorbent, a second layer made of a moisture-resistant material, and an adhesive layer on the bottom side of the second layer for temporary attachment to the foot bed of a shoe. A peel-off layer of paper covers the adhesive layer to prevent the shoe liners from sticking to each other or other objects before use.