Abstract: Intraocular devices together with methods for their preparation and use are provided, which are capable of sustained release of an antiproliferative agent, particularly an immunotoxin comprising a cytotoxic moiety. The intraocular devices are implanted in the eye where the immunotoxin is released from the intraocular device. The device may be used to inhibit proliferation of remnant lens epithelial cells, particularly after extracapsular cataract extractinon. The components of the device can be provided as kits, but preferably are provided in a form suitable for use with an IOL or coated onto an IOL.