Patents by Inventor Maureen T. Cronin

Maureen T. Cronin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE EXPRESSION MARKERS FOR BREAST CANCER PROGNOSIS
    Publication number: 20140287421
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: April 21, 2014
    Publication date: September 25, 2014
    Applicant: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steven Shak, Joffre B. Baker, Maureen T. Cronin
  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20140221329
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 7, 2014
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Methods of predicting cancer risk using gene expression in premalignant tissue
    Patent number: 8765383
    Abstract: The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: July 1, 2014
    Assignee: Genomic Health, Inc.
    Inventors: Wayne Cowens, Maureen T. Cronin, Carl L. Millward, Francois Collin, Michael Crager
  • Gene expression markers for breast cancer prognosis
    Patent number: 8741605
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: June 3, 2014
    Assignee: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Arrays of Nucleic Acid Probes for Analyzing Biotransformation Genes
    Publication number: 20130150248
    Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 13, 2013
    Applicant: AFFYMETRIX, INC.
    Inventors: Maureen T. Cronin, Charles G. Miyada, Earl A. Hubbell, Mark Chee, Stephen P.A. Fodor, Xiaohua C. Huang, Robert J. Lipshutz, Peter E. Lobban, MacDonald S. Morris, Edward L. Sheldon
  • ARRAYS OF NUCLEIC ACID PROBES FOR DETECTING CYSTIC FIBROSIS
    Publication number: 20120329677
    Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
    Type: Application
    Filed: August 18, 2006
    Publication date: December 27, 2012
    Inventors: Maureen T. Cronin, Charles Garrett Miyada, Earl A. Hubbell, Mark Chee, Stephen P.A. Fodor, Xiaohua C. Huang, Robert J. Lipshutz, Peter E. Lobban, MacDonald S. Morris, Edward L. Sheldon
  • Gene Expression Markers for Breast Cancer Prognosis
    Publication number: 20120225433
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 6, 2012
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • GENE EXPRESSION PROFILING OF EGFR POSITIVE CANCER
    Publication number: 20120178644
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Application
    Filed: January 10, 2012
    Publication date: July 12, 2012
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Gene expression markers for breast cancer prognosis
    Patent number: 8206919
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: June 26, 2012
    Assignee: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene expression profiling of EGFR positive cancer
    Patent number: 8148076
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: April 3, 2012
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steven Shak, Jose Baselga
  • Gene Expression Markers for Breast Cancer Prognosis
    Publication number: 20110312532
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Application
    Filed: August 30, 2011
    Publication date: December 22, 2011
    Inventors: Melody A. Cobleigh, Steve Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 8071286
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: December 6, 2011
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Gene expression markers for breast cancer prognosis
    Patent number: 8034565
    Abstract: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: October 11, 2011
    Assignee: Genomic Health, Inc.
    Inventors: Melody A. Cobleigh, Steven Shak, Joffre B. Baker, Maureen T. Cronin
  • Gene Expression Profiling of EGFR Positive Cancer
    Publication number: 20110245102
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Application
    Filed: June 1, 2011
    Publication date: October 6, 2011
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Gene expression profiling of EGFR positive cancer
    Patent number: 8008003
    Abstract: The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: August 30, 2011
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Steve Shak, Jose Baselga
  • Methods To Predict Clinical Outcome Of Cancer
    Publication number: 20110123990
    Abstract: The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer patient. The inventions also relates to computer systems and software for data analysis using the prognostic and statistical methods disclosed herein.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 26, 2011
    Inventors: Joffre B. BAKER, Maureen T. Cronin, Francois Collin, Mei-Lan Liu
  • Modified Nucleic Acid Probes
    Publication number: 20110092382
    Abstract: Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
    Type: Application
    Filed: September 9, 2010
    Publication date: April 21, 2011
    Applicant: AFFYMETRIX, INC.
    Inventors: GLENN HUGH MCGALL, CHARLES GARRETT MIYADA, MAUREEN T. CRONIN, JENNIFER DEE TAN, MARK S. CHEE
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 7858304
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: December 28, 2010
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker
  • Arrays of nucleic acid probes for analyzing biotransformation genes
    Patent number: 7846659
    Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: December 7, 2010
    Assignee: Affymetrix, Inc.
    Inventors: Maureen T. Cronin, Charles G Miyada, Earl A. Hubbell, Mark Chee, Stephen P. A. Fodor, Xiaohua C. Huang, Robert J. Lipshutz, Peter E. Lobban, MacDonald S. Morris, Edward L. Sheldon
  • Gene expression profiling in biopsied tumor tissues
    Patent number: 7838224
    Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: November 23, 2010
    Assignee: Genomic Health, Inc.
    Inventors: Joffre B. Baker, Maureen T. Cronin, Michael C. Kiefer, Steve Shak, Michael Graham Walker