Patents by Inventor Maurice Haufler

Maurice Haufler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibodies to crystal protein of Bacillus thuringiensis subspecies israelensis
    Patent number: 4945057
    Abstract: Murine hybridomas are disclosed which were constructed by fusing spleen cells from BALB/c mice immunized with soluble crystal protein from Bacillus thuringiensis subsp. israelensis (B.t.i.) to the murine myeloma cell line SP2/0-AG14. An ELISA (enzyme-linked immunosorbent assay) method for detection of antibodies specific for crystal protein of B.t.i. was modified to produce 100- to 1,000-fold increased sensitivity and was used to identify hybridomas secreting monoclonal antibody specific for the B.t.i. crystal protein. Analysis of the hybridoma culture supernatant fluid indicated production of monoclonal IgG3 antibodies, specific for the 68,000 dalton protein presumed to be the insecticidal delta-endotoxin of B.t.i.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: July 31, 1990
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Kevin B. Temeyer, Maurice Haufler, John H. Pruett