Patents by Inventor Maurice Van Eis

Maurice Van Eis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BICYCLIC HETEROARYL CYCLOALKYLDIAMINE DERIVATIVES AS INHIBITORS OF SPLEEN TYROSINE KINASES (SYK)
    Publication number: 20160213670
    Abstract: The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as SYK inhibitors and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: April 1, 2016
    Publication date: July 28, 2016
    Inventors: Peter Buehlmayer, Alexander Baxter Smith, Gebhard Thoma, Maurice Van Eis
  • Bicyclic heteroaryl cycloalkyldiamine derivatives
    Patent number: 9315500
    Abstract: The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as SYK inhibitors and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: April 19, 2016
    Assignee: NOVARTIS AG
    Inventors: Peter Buehlmayer, Alexander Baxter Smith, Gebhard Thoma, Maurice Van Eis
  • Monocyclic heteroaryl cycloalkyldiamine derivatives
    Patent number: 9290481
    Abstract: The present invention relates to monocyclic heteroaryl cycloalkyldiamine derivatives of formula (I), to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: March 22, 2016
    Assignee: NOVARTIS AG
    Inventors: Alexander Baxter Smith, Gebhard Thoma, Maurice Van Eis
  • Bicyclic Heteroaryl Cycloalkyldiamine Derivatives
    Publication number: 20150218157
    Abstract: The present invention relates to bicyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as SYK inhibitors and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: August 12, 2013
    Publication date: August 6, 2015
    Applicant: NOVARTIS AG
    Inventors: Peter Buehlmayer, Alexander Baxter Smith, Gebhard Thoma, Maurice Van Eis
  • Substituted indole derivatives
    Patent number: 9029396
    Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: May 12, 2015
    Assignee: Novartis AG
    Inventors: Nigel Graham Cooke, Rita Ramos, Karen Kammertoens, Maurice Van Eis
  • SUBSTITUTED INDOLE DERIVATIVES
    Publication number: 20140179634
    Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 3, 2014
    Publication date: June 26, 2014
    Applicant: NOVARTIS AG
    Inventors: Nigel Graham COOKE, Rita RAMOS, Karen KAMMERTOENS, Maurice VAN EIS
  • Indolylmaleimide derivatives processes for their production and pharmaceutical compositions
    Patent number: 8742132
    Abstract: A compound of formula (I) wherein R denotes another heterocyclic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: June 3, 2014
    Assignee: Novartis AG
    Inventors: Maurice Van Eis, Peter Von Matt, Jürgen Wagner
  • Substituted indole derivatives
    Patent number: 8703782
    Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: April 22, 2014
    Assignee: Novartis AG
    Inventors: Nigel Graham Cooke, Maurice Van Eis, Rita Ramos, Karen Kammertoens
  • Monocyclic Heteroaryl Cycloalkyldiamine Derivatives
    Publication number: 20130310387
    Abstract: The present invention relates to monocyclic heteroaryl cycloalkyldiamine derivatives, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 13, 2013
    Publication date: November 21, 2013
    Applicant: NOVARTIS AG
    Inventors: Gebhard Thoma, Alexander Baxter Smith, Maurice van Eis
  • SUBSTITUTED INDOLE DERIVATIVES
    Publication number: 20130157980
    Abstract: The present invention relates to substituted indole derivatives, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 15, 2012
    Publication date: June 20, 2013
    Applicant: NOVARTIS AG
    Inventors: Nigel Graham COOKE, Rita RAMOS, Karen KAMMERTOENS, Maurice VAN EIS
  • Indolymaleimide derivatives
    Patent number: 8426440
    Abstract: A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these compounds, and uses for these compounds and compositions, in particular, in transplantation.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: April 23, 2013
    Assignee: Novartis AG
    Inventors: Jurgen Wagner, Maurice Van Eis, Peter Von Matt, Jean-Pierre Evenou, Walter Schuler
  • 2,4- Di(hetero)-arylamino-pyrimidine derivatives as ZAP-70 and/or SYK inhibitors
    Patent number: 8283356
    Abstract: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: October 9, 2012
    Assignee: Novartis AG
    Inventors: Rolf Baenteli, Marie Claude Bernhard, Peter Buehlmayer, Nigel Graham Cooke, Rudolf Duthaler, Klaus Hinterding, Gebhard Thoma, Maurice Van Eis, Anette Von Matt, Louis Walliser, Gerhard Zenke
  • INDOLYLMALEIMIDE DERIVATIVES PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20120219593
    Abstract: A compound of formula (I) wherein R denotes another heterocyclic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Application
    Filed: May 7, 2012
    Publication date: August 30, 2012
    Inventors: Maurice VAN EIS, Peter VON MATT, Jürgen WAGNER
  • ORGANIC COMPOUNDS
    Publication number: 20120142685
    Abstract: The present invention provides a compound formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.
    Type: Application
    Filed: April 4, 2008
    Publication date: June 7, 2012
    Inventors: Markus Rolf Dobler, Charles Francis Jewell, JR., Erik Meredith, Lauren G. Monovich, Sarah Siska, Anette Von Matt, Maurice Van Eis, Taeyoung Yoon, Christoph Gaul, Michael Paul Capparelli
  • Indolylmaleimide derivatives processes for their production and pharmaceutical compositions
    Patent number: 8193236
    Abstract: A compound of formula (I) wherein R denotes another heterocylic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: June 5, 2012
    Assignee: Novartis AG
    Inventors: Maurice van Eis, Peter von Matt, Jurgen Wagner
  • Substituted pyrrole-2, 5-diones as protein kinase C inhibitors
    Patent number: 7851475
    Abstract: A compound of formula I wherein R, Ra and Rb are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: December 14, 2010
    Assignee: Novartis AG
    Inventors: Maurice Van Eis, Jürgen Wagner, Peter Von Matt
  • INDOLYMALEIMIDE DERIVATIVES
    Publication number: 20100273774
    Abstract: A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these compounds, and uses for these compounds and compositions, in particular, in transplantation.
    Type: Application
    Filed: July 9, 2010
    Publication date: October 28, 2010
    Inventors: Jürgen Wagner, Maurice Van Eis, Peter Von Matt, Jean-Pierre Evenou, Walter Schuler
  • Indolylmaleimide derivatives
    Patent number: 7781438
    Abstract: A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Jürgen Wagner, Maurice Van Eis, Peter Von Matt, Jean-Pierre Evenou, Walter Schuler
  • 2,4- Di(hetero)-arylamino-pyrimidine Derivatives as ZAP-70 and/or SYK inhibitors
    Publication number: 20100152182
    Abstract: Disclosed are pyrimidine derivatives of formula wherein R0, R1, R3 to R9, and Z have a signification as indicated in claim 1, which have interesting pharmaceutical properties.
    Type: Application
    Filed: January 13, 2010
    Publication date: June 17, 2010
    Inventors: Rolf Baenteli, Marie Claude Bernhard, Peter Buehlmayer, Nigel Graham Cooke, Rudolf Duthaler, Klaus Hinterding, Gebhard Thoma, Maurice Van Eis, Anette Von Matt, Louis Walliser, Gerhard Zenke
  • 2, 6-NAPHTHRIDINE DERIVATIVES
    Publication number: 20100130469
    Abstract: The present invention relates to novel organic compounds comprising a naphthyridine which may be mediators of a selective subset of kinases belonging to the AGC kinase family, such as for example PKC, PKD, PKN-1/2, CDK-9, MRCK-beat, PASK, PRKX, ROCK-I/II or mediators of other kinases, the selectivity of which would be depending on the structural variation thereof.
    Type: Application
    Filed: April 4, 2008
    Publication date: May 27, 2010
    Inventors: Maurice van Eis, Walter Schuler, Anette Von Matt, Nicolas Soldermann, Lauren G. Monovich, Christoph Gaul