Patents by Inventor Maurice W. Southworth

Maurice W. Southworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of toxic genes in vivo in a non-natural host
    Patent number: 8492117
    Abstract: Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an F? plasmid or on the chromosome.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: July 23, 2013
    Assignee: New England Biolabs, Inc.
    Inventors: James C. Samuelson, Theodore B. Davis, Elisabeth A. Raleigh, Maurice W. Southworth
  • Expression of Toxic Genes In Vivo in a Non-Natural Host
    Publication number: 20100129916
    Abstract: Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an F? plasmid or on the chromosome.
    Type: Application
    Filed: December 3, 2007
    Publication date: May 27, 2010
    Applicant: NEW ENGLAND BIOLABS ,INC.
    Inventors: James C. Samuelson, Theodore B. Davis, Elisabeth A. Raleigh, Maurice W. Southworth
  • Thermostable DNA polymerase from 9.degree.N-7 and methods for producing the same
    Patent number: 5756334
    Abstract: The present invention is directed to an extremely thermostable enzyme. More specifically, the invention is directed to a thermostable DNA polymerase 9.degree.N-7, as well as the recombinant form of 9.degree.N-7. In another embodiment, there is provided a method for mutagenizing the exo motif I of the 3'-5' exonuclease DNA polymerases from the native conserved DXE in the 3'-5' exo motif I DNA segment to DXD or AXA.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: May 26, 1998
    Assignee: New England Biolabs, Inc.
    Inventors: Francine B. Perler, Maurice W. Southworth