Abstract: A cartridge tray seal for a chemical process tower. The seal includes a teflon impregnated fiberglass member which presents a generally flaccid sealing element. The member is folded within a generally u-shaped channel positioned around the perimeter of the cartridge tray. A securing strap is positioned within the u-shaped channel to sandwich the fiberglass material therein in a configuration for presenting a pair of outwardly extending sealing lips for engagement against the shell wall. This double pliable seal is able to accommodate shell wall deformations and out-of-round conditions which would ordinarily result in liquid and/or vapor leakage around the cartridge tray.