Patents by Inventor Maurice Wilhelm

Maurice Wilhelm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine, pyrazine and triazane derivatives
    Patent number: 6673795
    Abstract: The present invention is a pyrimidine, triazine or pyrazine derivative of the formula or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, X, Y and Z are as defined in the specification. The invention is a pharmaceutical composition containing an effective amount of the compound of formula 1, its preparation and to a method of treatment, control or prevention of acute and/or chronic neurological disorders by administering a therapeutically effective amount of a compound of formula 1.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: January 6, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Thierry Masquelin, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine
    Patent number: 6586422
    Abstract: The invention relates to compounds which are represented by the formula wherein R1, R2, R3, R4, X and Y are as defined in the specification, as well as pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing these compounds and to a process for their preparation. The compounds possess affinity towards metabotropic glutamate receptors and are therefore useful in the treatment or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: July 1, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Pyrimidine, pyrazine and triazine derivatives
    Publication number: 20030060466
    Abstract: The present invention is a pyrimidine, triazine or pyrazine derivative of the formula 1
    Type: Application
    Filed: May 29, 2002
    Publication date: March 27, 2003
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Thierry Masquelin, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine
    Publication number: 20020123488
    Abstract: The invention relates to compounds which are represented by the formula 1
    Type: Application
    Filed: December 12, 2001
    Publication date: September 5, 2002
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Novel mGluR antagonists and a method for their synthesis
    Publication number: 20020045635
    Abstract: The invention relates to nitro- and cyano-1,2,4,5-tetrahydro-heterocycloazepinyl pyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to medicaments containing such compounds and a process for the preparation of such compounds. The compounds of the invention are group I mGluR antagonists and are therefore useful for the control or prevention of acute and/or chronic neurological disorders.
    Type: Application
    Filed: July 11, 2001
    Publication date: April 18, 2002
    Inventors: Alfred Binggeli, Hans-Peter Maerki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • 1,2,4,5-Tetrahydro-benzo[D]azepin derivatives
    Patent number: 6218385
    Abstract: The present invention is concerned with 1,2,4,5-tetrahydro-benzo[d]azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors and therefore useful for the treatment of diseases related to these receptors.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: April 17, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alfred Binggeli, Hans-Peter Märki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Piperidine derivative having renin inhibiting activity
    Patent number: 6150526
    Abstract: Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: November 21, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl
  • Piperidine derivatives having renin inhibiting activity
    Patent number: 6051712
    Abstract: Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: April 18, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl