Abstract: Provided herein are gene-editing methods and compositions for improving the efficiency of deleting segments of DNA from cells, cells that are genetically modified using the disclosed methods and compositions, and methods of treatment using the genetically modified cells.

Abstract: Microstrip routing circuits with dielectric films are disclosed. A disclosed example apparatus includes a substrate, the substrate having a first side and a second side opposite the first side, the first side and the second side defining a height of the substrate, traces on the first side of the substrate, and a dielectric film positioned on the first side to cover at least a portion of the traces.

Abstract: The present disclosure provides methods for increasing the quantity and/or the ratios of erythroblasts, reticulocytes, and/or erythrocytes, or progenitors thereof, in which any of these cells express HbF (e.g. HbF+ and/or HbFhigh cells). The present disclosure further provides methods for treating diseases or disorders characterized by, for example, oxygen delivery deficiencies and/or reduced expression and/or activity of hemoglobin. Such diseases, without limitation, are mitigated by therapeutic reactivation of HbF.

Abstract: A system, article, and method of detection of acoustic source aiming direction uses multiple microphones.

Abstract: Various systems and methods for implementing a vehicle with an external speaker and microphone are described herein. A system includes an audio processor to receive audio data, the audio data sensed by a microphone array installed on the vehicle, the audio data generated by a source outside of the vehicle; an audio classification circuit to analyze the audio data using a machine learning technique to determine a sound event; and a vehicle interface to transmit a message to a vehicle control system, the message based on the sound event.

Abstract: Various example embodiments for supporting communications for stream processing platforms are described. Various example embodiments for supporting communications in a stream processing platform may be configured to use micro-brokers to support communications in a stream processing platform by providing micro-brokers configured to support communications between operators of operator groups of the stream processing platform. Various example embodiments for supporting communications in a stream processing platform may be configured to use micro-brokers to support communications in the stream processing platform by providing micro-brokers configured to support communications between operators of operator groups of the stream processing platform using various communication modes (e.g.

Abstract: Various example embodiments for supporting communications for stream processing platforms are described. Various example embodiments for supporting communications in a stream processing platform may be configured to use micro-brokers to support communications in a stream processing platform by providing micro-brokers configured to support communications between operators of operator groups of the stream processing platform. Various example embodiments for supporting communications in a stream processing platform may be configured to use micro-brokers to support communications in the stream processing platform by providing micro-brokers configured to support communications between operators of operator groups of the stream processing platform using various communication modes (e.g.

Abstract: Provided herein are gene-editing methods and compositions for improving the efficiency of deleting segments of DNA from cells, cells that are genetically modified using the disclosed methods and compositions, and methods of treatment using the genetically modified cells.

Abstract: Various systems and methods for implementing a vehicle with an external speaker and microphone are described herein. A system includes an audio processor to receive audio data, the audio data sensed by a microphone array installed on the vehicle, the audio data generated by a source outside of the vehicle; an audio classification circuit to analyze the audio data using a machine learning technique to determine a sound event; and a vehicle interface to transmit a message to a vehicle control system, the message based on the sound event.

Abstract: A device testing capability is presented herein. The device testing capability supports automated testing of media devices (e.g., cameras, microphones, speakers, or the like) for verifying that the media devices are functioning properly. The device testing capability may support automated verification by an endpoint that one or more media devices or one or more sets of media devices associated with endpoint are functioning properly. For example, the device testing capability may support automated verification by a computer that a camera associated with the computer is functioning properly. For example, the device testing capability may support automated verification by a computer that a speaker and a microphone that are associated with the computer are functioning properly. The device testing capability may support automated verification, by a management system, of the proper functioning of media devices associated with endpoints in a set of endpoints.

Abstract: A device testing capability is presented herein. The device testing capability supports automated testing of media devices (e.g., cameras, microphones, speakers, or the like) for verifying that the media devices are functioning properly. The device testing capability may support automated verification by an endpoint that one or more media devices or one or more sets of media devices associated with endpoint are functioning properly. For example, the device testing capability may support automated verification by a computer that a camera associated with the computer is functioning properly. For example, the device testing capability may support automated verification by a computer that a speaker and a microphone that are associated with the computer are functioning properly. The device testing capability may support automated verification, by a management system, of the proper functioning of media devices associated with endpoints in a set of endpoints.

Abstract: A replica/cache locator, a method to locate replication tables and caches in an overlay network having multiple nodes and an overlay network. In one embodiment, the method includes: (1) determining a network distance between a first node of the multiple nodes in the overlay network and each of the remaining multiple nodes, (2) calculating m clusters of the multiple nodes based on the network distances and (3) designating at least a single node from the m clusters to include a replication table of the first node.

Abstract: A method and apparatus in which a mobile network advantageously communicates data requests to neighboring data stores so that they may pre-fetch the data. In particular, in accordance with an illustrative embodiment of the present invention, a protocol is advantageously established whereby a local data store in a mobile network notifies neighboring data stores of data requests, and whereby the neighboring data stores advantageously pre-fetch the data that may be required, thereby advantageously avoiding cascading cache misses. Such notifications may advantageously reduce the number of cache misses, which in turn may advantageously reduce the latency to download data as the user moves around within the mobile network and changes data sources. Specifically, in accordance with an illustrative embodiment of the present invention, a protocol for communicating data requests between local storage centers in a network supporting mobile users is provided.

Abstract: In a sensor system, an edge element receives data from at least one mobile sensor, and sends the data which may be preprocessed by the edge element to a server for further processing. The edge element may communicate to the mobile sensor to change a value of a run-time parameter in the mobile sensor to affect its operation. The edge element may also cause the mobile sensor to upgrade its firmware. When the mobile sensor is about to leave communication coverage of the edge element, the latter may initiate a peer-to-peer handover of the control and administration of the mobile sensor to another edge element in the sensor system.

Abstract: An exemplary method of determining location information includes transmitting a modeling signal from each of a plurality of detectors. Each of the plurality of detectors receives at least one of the transmitted modeling signals from the other detectors. At least one characteristic of each of the received modeling signals is determined. A signal propagation model for an area near each of the detectors is automatically determined based on the characteristic of each of the received modeling signals. The determined propagation model indicates an effect on a signal received within the corresponding area.

Abstract: The present invention provides a resource-sensitive parser for use with a session initiation protocol (SIP) network. In one embodiment, the resource-sensitive parser includes a resource condition indicator configured to provide an overload indication for a network element in the SIP network. Additionally, the resource-sensitive parser also includes a parsing engine coupled to the resource condition indicator and configured to parse a SIP request employing an overload protection mode corresponding to the overload indication for the network element.

Abstract: There is provided a system and method for prioritizing session initiation protocol (“SIP”) messages. More specifically, in one embodiment, there is provided a method of prioritizing SIP messages in a network, the method comprising receiving SIP messages in a first order from one or more other servers of the network, wherein each of the received SIP messages comprises one or more priority indicators, scheduling the received SIP messages into a second order based on one or more of the priority indicators, and processing the scheduled SIP messages in the second order.

Abstract: Example embodiments provide methods of transparently migrating a reliable transport layer connection between a user and a first base station and a second base station in a wireless network. The method includes receiving at least one transport layer connection state information parameter from the first base station at the second base station. The second base station then determines at least one new transport layer connection parameter based on the at least one transferred transport layer connection state information parameter and at least one network condition at the second base station.

Abstract: A method and apparatus for encoding a SIP message into an internal binary format so that it can be treated much more efficiently by both the SIP stack layers and the application. Only one memory buffer is used to handle any sort of SIP message. For this reason, this new SIP message may be called a “mono-block” structure. It allows each SIP header's raw text from the original SIP message to be directly referred within the SIP mono-block with no additional copy. Only SIP headers that are “used” by the application, or by some SIP stack layer are parsed to form a “decoded” header object. The header parsing is made “on demand” at the moment header is accessed. Headers not used are not decoded and are left in text format with no additional processing needed.

Abstract: A method and apparatus in which a mobile network advantageously communicates data requests to neighboring data stores so that they may pre-fetch the data. In particular, in accordance with an illustrative embodiment of the present invention, a protocol is advantageously established whereby a local data store in a mobile network notifies neighboring data stores of data requests, and whereby the neighboring data stores advantageously pre-fetch the data that may be required, thereby advantageously avoiding cascading cache misses. Such notifications may advantageously reduce the number of cache misses, which in turn may advantageously reduce the latency to download data as the user moves around within the mobile network and changes data sources. Specifically, in accordance with an illustrative embodiment of the present invention, a protocol for communicating data requests between local storage centers in a network supporting mobile users is provided.