Abstract: The present invention relates to pharmaceutical, dietary and/or food compositions exerting the ability to activate the endogenous production of hydrogen sulfide (H2S) so to feed the redox buffer capacity and to boost the natural ability to compensate both oxidative and reductive stress. The invention further relates to the use of the aforementioned compositions to correct signs of metabolic derangements such as: oxy-redox imbalances including reductive stress, mitochondrial dysfunction and bioenergetics, insulin resistance, endothelial dysfunction and hyperhomocysteinemia. Accordingly, the composition of the present invention can be used as a medicament for the treatment of hypertension, atherosclerosis and cardiovascular disease, erectile dysfunction, viral infections and inflammatory lung injuries, diabetes and PCOS, autoimmune diseases, neurodegeneration, repeated implantation failure and repeated miscarriage and infertility in both men and women.

Abstract: The invention describes pharmaceutical, dietary and/or food compositions, preferably dietary supplements, exerting the ability to activate the endogenous antioxidant system by feeding essential micronutrients to both the one carbon cycle and the trans-sulfuration pathway so to achieve effective oxy-redox homeostasis together with an improved energy balance and healthy processes of cell growth and differentiation including DNA methylation and epigenetic regulation. The invention further relates to the use of the aforementioned compositions to decrease homocysteine levels and for the support to menopause, pregnancy and reproductive competence and for the prevention and/or treatment of diabetes, celiac disease, neurodegenerative diseases, cardiovascular diseases, Autism Spectrum Disorders (ASD) or Neurodevelopmental Disorders.

Abstract: The invention describes pharmaceutical, dietary and/or food compositions, preferably dietary supplements, exerting the ability to activate the endogenous antioxidant system by feeding essential micronutrients to both the one carbon cycle and the trans-sulfuration pathway so to achieve effective oxy-redox homeostasis together with an improved energy balance and healthy processes of cell growth and differentiation including DNA methylation and epigenetic regulation. The invention further relates to the use of the aforementioned compositions to decrease homocysteine levels and for the support to menopause, pregnancy and reproductive competence and for the prevention and/or treatment of diabetes, celiac disease, neurodegenerative diseases, cardiovascular diseases, Autism Spectrum Disorders (ASD) or Neurodevelopmental Disorders.

Abstract: Herein is described a new method for partition and inactivating of viral and prion contaminants contained in a solution. The method is based on ultracentrifugation of the solution in a centrifuge tube at the bottom of which a high molarity urea solution is layered. The system can include a cushion solution interposed as an intermediate liquid phase between the starting solution and the urea solution.