Patents by Inventor Maurizio Denaro
Maurizio Denaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6159746Abstract: Solid phase immunoassay for detecting specific inhibitors of proteolytic enzymes in biological fluids, which comprises: a) contacting a tubulin peptide covalently linked to a support with a solution containing a proteolytic activity together with a protease inhibitor, b) detecting the inhibitor activity against the selected proteases by contacting the support with a solution containing a labelled monoclonal antibody which specifically recognises the free end of the tubulin peptide linked to the support.Type: GrantFiled: September 23, 1996Date of Patent: December 12, 2000Assignee: Gruppo Lepetit S.p.A.Inventors: Khalid Islam, Lucia Carrano, Maurizio Denaro
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Patent number: 5990160Abstract: The present invention concerns the use of puberulic or puberulonic acid as inhibitors of the enzyme iositol monophosphatase (EC 3.1.3.25) and thus useful in the treatment of manic or depressive symptoms.Type: GrantFiled: May 14, 1999Date of Patent: November 23, 1999Assignee: Gruppo Lepetit, SpAInventors: Khalid Islam, Stefania Stefanelli, Federica Sponga, Maurizio Denaro
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Patent number: 5854036Abstract: The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.Type: GrantFiled: September 10, 1996Date of Patent: December 29, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Stefania Stefanelli, Federica Sponga, Khalid Islam, Maurizio Denaro, Pietro Ferrari
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Patent number: 5843890Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.Type: GrantFiled: June 5, 1995Date of Patent: December 1, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Paolo Tavecchia, Ermenegildo Restelli, Pietro Ferrari, Maurizio Denaro
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Patent number: 5843679Abstract: The present invention is directed to a method for selectively enhancing the production of factors A, and/or B.sub.0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A 40926 producing culture during fermentation.Type: GrantFiled: June 2, 1995Date of Patent: December 1, 1998Assignee: Biosearch Italia S.p.A.Inventors: Enrico Selva, Luciano Gastaldo, Maurizio Denaro, Giovanni Cassani, Francesco Parenti
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Patent number: 5786350Abstract: Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C.sub.1 -C.sub.8)alkyl, halo, hydroxy, (C.sub.1 -C.sub.4)acyloxy, (C.sub.1-C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1-C.sub.4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.Type: GrantFiled: January 31, 1997Date of Patent: July 28, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Emilio Occelli, Sergio Lociuro, Romeo Ciabatti, Maurizio Denaro
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Patent number: 5752941Abstract: The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.Type: GrantFiled: August 2, 1996Date of Patent: May 19, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Gabriella Romano', Beth P. Goldstein, Rosamund Jean Williams, Maurizio Denaro
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Patent number: 5747295Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.Type: GrantFiled: June 2, 1995Date of Patent: May 5, 1998Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Paolo Tavecchia, Ermenegildo Restelli, Pietro Ferrari, Maurizio Denaro
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Patent number: 5674490Abstract: The present invention is directed to a new antibiotic denominated antibiotic GE1655 complex, its factors antibiotic GE1655 factor A, antibiotic GE1655 factor B, and antibiotic GE1655 factor C, the pharmaceutical acceptable salts thereof, the pharmaceutical compositions thereof, and their use as medicaments against bacteria and fungi, particularly for the treatment of fungal infections in animals and human beings.Type: GrantFiled: May 31, 1995Date of Patent: October 7, 1997Assignee: Gruppa Lepetit S.p.A.Inventors: Franco Maria Spreafico, Ernesto Riva, Graziella Beretta, Khalid Islam, Maurizio Denaro
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Patent number: 5618724Abstract: The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.Type: GrantFiled: May 16, 1996Date of Patent: April 8, 1997Assignee: Gruppo Lepetit SpAInventors: Sergio Stella, Nicoletta Montanini, Francis J. LeMonnier, Luigi Colombo, Enrico Selva, Maurizio Denaro
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Patent number: 5610143Abstract: The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.Type: GrantFiled: June 21, 1995Date of Patent: March 11, 1997Assignee: Gruppo Lepetit S.p.A.Inventors: Sergio Stella, Nicoletta Montanini, Francis J. LeMonnier, Luigi Colombo, Enrico Selva, Maurizio Denaro
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Patent number: 5606036Abstract: The present invention relates to novel ester derivatives of antibiotic A 40926 complex and its N-acylaminoglucuronyl aglycone. The compounds of the invention are prepared according to an esterification process involving reaction of an A 40926 substrate with an excess of the selected alkanol in the presence of concentrated mineral acid and are reactive as antibiotics.Type: GrantFiled: May 22, 1995Date of Patent: February 25, 1997Assignee: Gruppo Lepetit SpAInventors: Rolf H. Hermann, Romeo Ciabatti, Enrico Selva, Maurizio Denaro
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Patent number: 5567676Abstract: The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.Type: GrantFiled: June 1, 1995Date of Patent: October 22, 1996Assignee: Gruppo Lepetit S.p.AInventors: Enrico Selva, Grazia Beretta, Angelo Borghi, Maurizio Denaro
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Patent number: 5514649Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.Type: GrantFiled: April 21, 1995Date of Patent: May 7, 1996Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Sergio Stella, Luigi Colombo, Maurizio Denaro
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Patent number: 5322777Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.Type: GrantFiled: October 14, 1992Date of Patent: June 21, 1994Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
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Patent number: 5202241Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.Type: GrantFiled: June 11, 1991Date of Patent: April 13, 1993Assignee: Gruppo Lepetit S.p.A.Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
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Patent number: 4956293Abstract: A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.Type: GrantFiled: November 14, 1988Date of Patent: September 11, 1990Assignee: Gruppo Lepetit S.p.A.Inventors: Ernesto Riva, Maurizio Denaro, Enrico Selva, Giovanni Cassani, Francesco Parenti
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Patent number: 4908351Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic A 42867 pseudoaglycon, a pharmaceutically acceptable salt thereof, a process for its preparation from antibiotic A 42867 and pharmaceutical compositions containing the new substance of the invention.Type: GrantFiled: January 24, 1989Date of Patent: March 13, 1990Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Ernesto Riva, Maurizio Denaro, Pietro Ferrari, Giovanni Cassani
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Patent number: 4804534Abstract: A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.Type: GrantFiled: July 28, 1987Date of Patent: February 14, 1989Assignee: Gruppo Lepetit S.p.A.Inventors: Ernesto Riva, Enrico Selva, Maurizio Denaro, Giovanni Cassani, Francesco Parenti