Patents by Inventor Maurizio Denaro

Maurizio Denaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6159746
    Abstract: Solid phase immunoassay for detecting specific inhibitors of proteolytic enzymes in biological fluids, which comprises: a) contacting a tubulin peptide covalently linked to a support with a solution containing a proteolytic activity together with a protease inhibitor, b) detecting the inhibitor activity against the selected proteases by contacting the support with a solution containing a labelled monoclonal antibody which specifically recognises the free end of the tubulin peptide linked to the support.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: December 12, 2000
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Khalid Islam, Lucia Carrano, Maurizio Denaro
  • Patent number: 5990160
    Abstract: The present invention concerns the use of puberulic or puberulonic acid as inhibitors of the enzyme iositol monophosphatase (EC 3.1.3.25) and thus useful in the treatment of manic or depressive symptoms.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: November 23, 1999
    Assignee: Gruppo Lepetit, SpA
    Inventors: Khalid Islam, Stefania Stefanelli, Federica Sponga, Maurizio Denaro
  • Patent number: 5854036
    Abstract: The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.
    Type: Grant
    Filed: September 10, 1996
    Date of Patent: December 29, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Stefania Stefanelli, Federica Sponga, Khalid Islam, Maurizio Denaro, Pietro Ferrari
  • Patent number: 5843679
    Abstract: The present invention is directed to a method for selectively enhancing the production of factors A, and/or B.sub.0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A 40926 producing culture during fermentation.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 1, 1998
    Assignee: Biosearch Italia S.p.A.
    Inventors: Enrico Selva, Luciano Gastaldo, Maurizio Denaro, Giovanni Cassani, Francesco Parenti
  • Patent number: 5843890
    Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 1, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Paolo Tavecchia, Ermenegildo Restelli, Pietro Ferrari, Maurizio Denaro
  • Patent number: 5786350
    Abstract: Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C.sub.1 -C.sub.8)alkyl, halo, hydroxy, (C.sub.1 -C.sub.4)acyloxy, (C.sub.1-C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1-C.sub.4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: July 28, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Emilio Occelli, Sergio Lociuro, Romeo Ciabatti, Maurizio Denaro
  • Patent number: 5752941
    Abstract: The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: May 19, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Gabriella Romano', Beth P. Goldstein, Rosamund Jean Williams, Maurizio Denaro
  • Patent number: 5747295
    Abstract: The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 5, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Paolo Tavecchia, Ermenegildo Restelli, Pietro Ferrari, Maurizio Denaro
  • Patent number: 5674490
    Abstract: The present invention is directed to a new antibiotic denominated antibiotic GE1655 complex, its factors antibiotic GE1655 factor A, antibiotic GE1655 factor B, and antibiotic GE1655 factor C, the pharmaceutical acceptable salts thereof, the pharmaceutical compositions thereof, and their use as medicaments against bacteria and fungi, particularly for the treatment of fungal infections in animals and human beings.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: October 7, 1997
    Assignee: Gruppa Lepetit S.p.A.
    Inventors: Franco Maria Spreafico, Ernesto Riva, Graziella Beretta, Khalid Islam, Maurizio Denaro
  • Patent number: 5618724
    Abstract: The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: April 8, 1997
    Assignee: Gruppo Lepetit SpA
    Inventors: Sergio Stella, Nicoletta Montanini, Francis J. LeMonnier, Luigi Colombo, Enrico Selva, Maurizio Denaro
  • Patent number: 5610143
    Abstract: The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: March 11, 1997
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Sergio Stella, Nicoletta Montanini, Francis J. LeMonnier, Luigi Colombo, Enrico Selva, Maurizio Denaro
  • Patent number: 5606036
    Abstract: The present invention relates to novel ester derivatives of antibiotic A 40926 complex and its N-acylaminoglucuronyl aglycone. The compounds of the invention are prepared according to an esterification process involving reaction of an A 40926 substrate with an excess of the selected alkanol in the presence of concentrated mineral acid and are reactive as antibiotics.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: February 25, 1997
    Assignee: Gruppo Lepetit SpA
    Inventors: Rolf H. Hermann, Romeo Ciabatti, Enrico Selva, Maurizio Denaro
  • Patent number: 5567676
    Abstract: The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 22, 1996
    Assignee: Gruppo Lepetit S.p.A
    Inventors: Enrico Selva, Grazia Beretta, Angelo Borghi, Maurizio Denaro
  • Patent number: 5514649
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Sergio Stella, Luigi Colombo, Maurizio Denaro
  • Patent number: 5322777
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: June 21, 1994
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Patent number: 5202241
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 13, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Patent number: 4956293
    Abstract: A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: September 11, 1990
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Ernesto Riva, Maurizio Denaro, Enrico Selva, Giovanni Cassani, Francesco Parenti
  • Patent number: 4908351
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic A 42867 pseudoaglycon, a pharmaceutically acceptable salt thereof, a process for its preparation from antibiotic A 42867 and pharmaceutical compositions containing the new substance of the invention.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: March 13, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Ernesto Riva, Maurizio Denaro, Pietro Ferrari, Giovanni Cassani
  • Patent number: 4804534
    Abstract: A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: February 14, 1989
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Ernesto Riva, Enrico Selva, Maurizio Denaro, Giovanni Cassani, Francesco Parenti