Patents by Inventor Mauro Botta

Mauro Botta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced substrate imaging by reversible binding to a paramagnetic complex
    Patent number: 7608249
    Abstract: The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a reversible binding of the substrate molecule to a paramagnetic chelate complex, as well as to the use of a paramagnetic chelate complex in said method and the pharmaceutical composition for use therein.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: October 27, 2009
    Assignee: Bracco Imaging S.p.A.
    Inventors: Enzo Terreno, Silvio Aime, Mauro Botta
  • Enhanced substrate imaging by reversible binding to a paramagnetic complex
    Publication number: 20040258618
    Abstract: The invention relates to a method for the Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Imaging of a substrate molecule different from water wherein the NMR signal is enhanced by a reversible binding of the substrate molecule to a paramagnetic chelate complex, as well as to the use of a paramagnetic chelate complex in said method and the pharmaceutical composition for use therein.
    Type: Application
    Filed: August 16, 2004
    Publication date: December 23, 2004
    Inventors: Enzo Terreno, Silvio Aime, Mauro Botta
  • Insoluble salts of lanthanides for the visual display using nuclear magnetic resonance, of the gastro-intestinal tract
    Patent number: 5368839
    Abstract: Diagnostic compositions particularly useful for NMR imaging of the gastrointestinal tract, comprise physiologically acceptable aqueous suspensions of insoluble salts of lanthanides, buffered, if required, at a pH value between 6.0 and 8.5 and which are, if required, formulated with appropriate insoluble organic or inorganic additives and/or with dispersing agents, suspending agents or viscosity-enhancing agents. These compositions are capable of increasing the value of the r.sub.2 /r.sub.1 ratio, in which r.sub.1 and r.sub.2 are the longitudinal and transversal relaxivities of the protons of the surrounding water, thus permittting the production of clear images which have negative contrast and which lack artefacts of metallic type.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: November 29, 1994
    Assignee: Bracco S.p.A.
    Inventors: Silvio Aime, Mauro Botta